Novigan tabs #20

Instruction for Novigan tablets

Reed more and buy Novigan pills on this page

Composition

The active ingredient contains 5 mg of pentophenone hydrochloride, 400 mg of ibuprofen, 0.1 mg of fenpiverinium bromide.
Excipients: 76 mg of corn starch, 5 mg of colloidal silicon dioxide, 4 mg of magnesium stearate, 55 mg of MCC, 12 mg of talc, and 2.9 mg of glycerol.
The composition of the film shell of the shell: 1.124 mg macrogol 6000, 1.059 mg of titanium dioxide, 0.058 mg of sorbic acid, 5.686 mg of hypromellose 6 cps, 1.957 mg of talc, 0.058 mg of polysorbate 80, 0.058 mg of dimethicone.

Form of issue

The drug is available in the form of tablets in a shell of 10 pieces in a blister pack. The cardboard pack contains 2, 10 or 20 blisters with tablets, as well as instructions for use.
There is a form of release in tablets coated with a film membrane. In one blister, there are 10 tablets. In the cardboard box is an instruction for the use of the drug, as well as one or two blisters.

pharmachologic effect

Tablets have anti-inflammatory, analgesic and antispasmodic effects.

Indications for use

Novigan tablets are Prescribed when:
    moderately or mildly expressed pain syndrome, observed when smooth muscles of internal organs are subjected to spasms - intestinal, biliary and renal colic, as well as in case of dyskinesia of bile ducts;
    dysmenorrhea;
    headache, including having a migraine nature;
    symptomatic short-term treatment for neuralgia, myalgia, ischialgia and joint pain.

Pharmacodynamics and pharmacokinetics

Novigan is a combined preparation that has antispasmodic, anti-inflammatory and analgesic effects. The drug suppresses the synthesis of prostaglandin. The drug contains ibuprofen, which is a non-steroidal anti-inflammatory drug, fenpiverinia bromide is an m-cholinoblocking agent with peripheral and central effects, as well as a myotropic antispasmodic agent of the hydrochloride of the pitofenone.
Pitophenone hydrochloride causes relaxation of the musculature of the internal organs, exerting a direct myotropic effect on it.
Ibuprofen (derived from phenylpropionic acid) has analgesic, anti-inflammatory and antipyretic effects. The main effect of the substance is to inhibit the synthesis of prostaglandins, which are modulators of thermoregulation, pain sensitivity and inflammation in peripheral tissues and the central nervous system. In women suffering from primary dysmenorrhea, the level of prostaglandins in myometrium decreases, thereby reducing the heart rate and intrauterine pressure.
Fenpiverinia bromide exerts an additional relaxing effect on the smooth muscles due to its anticholinergic action.
Combined, these three main components mutually reinforce each other's pharmacological action.
The components that make up Novigan are perfectly absorbed into the digestive tract. After taking, approximately 1-2 hours later, the peak concentration of the drug is reached in the blood plasma. Ibuprofen, the main component of this drug, almost completely (by 99%) binds to blood plasma proteins, and its accumulation in synovial fluid can also occur. This component is metabolized in the liver and 90% is excreted along with urine in the form of conjugates and metabolites. An insignificant part of Noghvrana, along with bile, is escaped. Half-life from the blood plasma - 2 hours.

Contraindications

The drug is contraindicated in:
    anamnestic data on the attack of rhinitis, hives, bronchial obstruction after taking acetylsalicylic acid or any other non-steroidal anti-inflammatory drug (with incomplete or complete syndrome of intolerance to acetylsolicylic acid - hives, bronchial asthma, rhinosinusitis, polyps of the nasal mucosa);
    inflammatory bowel diseases in the phase of exacerbation, including ulcerative colitis;
    erosive and ulcerative changes in the mucous membrane of the duodenum or stomach, as well as with active bleeding in the gastrointestinal tract;
    active liver disease or liver failure;
    progressive kidney disease or renal failure (Cl creatinine is less than 30ml / min);
    hemophilia or any other disorders of blood clotting (including hypocoagulation), hemorrhagic diathesis;
    confirmed hyperkalemia;
    acute intermittent porphyria;
    hematopoietic disorders;
    tachyarrhythmias;
    deficiency of glucose-b-phosphate dehydrogenase;
    granulocytopenia;
    angle-closure glaucoma;
    hyperplasia of the prostate;
    intestinal obstruction;
    diseases of the optic nerve;
    the period of breastfeeding or pregnancy;
    in the period after aortocoronary bypass surgery was performed;
    individual intolerance to the components contained in the preparation;
    age of the patient is under 16 years.
In addition, the drug should be taken with caution when:
    elderly patient;
    cerebrovascular diseases;
    heart failure;
    hyperlipidemia / dyslipidemia;
    arterial hypertension;
    diabetes mellitus;
    Cl creatinine 30-60 ml / min;
    ischemic heart disease;
    nephrotic syndrome;
    hyperbilirubinemia;
    congestive heart failure;
    diseases of peripheral arteries;
    peptic ulcer of the duodenum and stomach (in the anamnesis);
    presence of Helicobacter pylori infection;
    colitis;
    gastritis;
    esterite;
    long-term use of non-steroidal anti-inflammatory drugs;
    severe somatic diseases;
    alcoholism or smoking;
    blood diseases of unclear etiology (anemia, leukopenia);
    concomitant therapy with anticoagulants (eg, Warfarin), oral GCS (for example, Prednisolone), antiaggregants (clopidogrel, acetylsolicylic acid, etc.), and also with SSRIs (eg, fluoxetine, sertraline, citalopram, paroxetine).

Side effects

In case of taking the drug at recommended dosages, side effects should not be manifested.
For the gastrointestinal tract: pain in the mouth, aphthous stomatitis, ulceration of the mucous membrane of the gastrointestinal tract, sometimes complicated by bleeding and perforation, ulceration of the mucous membrane of the gums, NSAID-gastropathy (nausea, heartburn, vomiting, decreased appetite, abdominal pain, flatulence, diarrhea, constipation), in oral cavity may appear dry and irritation of the mucosa, pancreatitis.
For the respiratory system: bronchospasm, dyspnea.
For the hepabolitic system: hepatitis.
For the peripheral and central nervous system: anxiety, dizziness, confusion, insomnia, irritability and nervousness, depression, hallucinations, psychomotor agitation, headache, drowsiness, as well as aseptic meningitis, which is most often observed in patients suffering from autoimmune diseases.
For the cardiovascular system: tachycardia, increased blood pressure, heart failure.
For the senses: blurred vision - blurred vision, irritation, and dryness of the eyes, scotoma, swelling of the eyelids and conjunctiva, paresis of accommodation, as well as hearing loss - its deterioration, as well as ringing or noise in the ears.
For hemopoiesis: leukopenia, anemia (including also hemolytic aplastic), agranulocytosis, thrombocytopenic purpura and thrombocytopenia.
For the urinary system: acute renal failure, allergic nephritis, oliguria, proteinuria, nephrotic syndrome (edema), anuria, polyuria, and urine is colored red.
Allergic reactions: fever, anaphylactoid reaction, dyspnea or bronchospasm, pruritus, erythema multiforme exudative (including Stevens-Johnson syndrome), eosinophilia, skin rash (usually urticaria or erythematous), anaphylaxis, angioedema, toxic epidermal necrolysis, allergic rhinitis.
Laboratory parameters: the serum glucose concentration can be reduced can be increased bleeding time can be reduced creatinine clearance, may occur a decrease in hemoglobin or hematocrit can be increased liver transaminase activity, and can be increased serum creatinine concentration.
Other side effects: decreased or increased sweating.
In the event that in the normal state of taking the drug there have been changes, you must immediately stop taking the drug and without delay seek help from a doctor.

Instructions for use Novigan (Method and dosage)

Please reed this instruction before buy Novigan.
The drug is taken orally an hour before meals or after eating three hours later. To avoid the negative irritant effect of the drug on the stomach, you can take Novigan immediately after eating or you can take the tablets with milk.
In the absence of any prescription of the doctor for admission, with Novigan spasmodic pain, it is recommended to take three times a day for one tablet. The maximum dose of the drug per day - three tablets Novigan.
Instructions for use also warns that without a doctor's consultation, the course of taking tablets should not last more than five days. If you need to use the drug for a longer time, it is done only under the supervision of a doctor and strict control of indicators of the functional state of the liver and peripheral blood.

Overdose

Symptoms of overdose include: lethargy, nausea, abdominal pain, drowsiness, vomiting, depression, metabolic acidosis, tinnitus, decrease in blood pressure, atrial fibrillation, headache, acute renal failure, respiratory failure and coma.
As the treatment is used: alkaline drink, gastric lavage (maximum - after 3 hours), forced diuresis, and also assigned activated charcoal or symptomatic therapy is applied (blood pressure, acid-base state is corrected). However, there is no specific antidote to the drug that could be used in case of an overdose.
If the recommended dosage is exceeded, the doctor should be consulted without delay. At itself it is necessary to have a package of a preparation.

Interaction

When taking Novigan in therapeutic doses with other commonly used medications, no significant interactions occur.
Inhibitors of microsomal oxidation reduces the risk that hepatotoxic action will be developed.
The liver enzyme inducers of microsomal oxidation (ethanol, flumetsinol, phenylbutazone, fenitonin, rifampicin, tricyclic antidepressants, barbiturates) increases production of active hydroxylated metabolites, thereby increasing the risk that severe toxicity will develop.
The natriuretic effect of hydrochlorothiazide and furosemide decreases, as well as the hypotensive activity of vasodilators.
The effectiveness of uricosuric drugs is reduced.
Increased risk that bleeding will develop because of increased drug effects of fibrinolytics, indirect anticoagulants and antiaggregants.
Absorption of ibuprofen is reduced by colestyramine and antacids.
The drug enhances the likely side effects of estrogens, ethanol, GCS (increases the risk that there will be gastrointestinal bleeding), mineralocorticosteroids; derivatives of sulfonylurea in the interaction with the drug enhance their hypoglycemic effect.
The concentration of digoxin in the blood, as well as preparations of methotrexate and lithium increases.
Simultaneous reception of the drug with other non-steroidal anti-inflammatory drugs increases the frequency of possible side effects.
The effect of butyrofenones, quinidine, phenothiazines, blockers of H1-histamine receptors, amantadine, and m-holinoblockers is enhanced.
When the drug interacts with caffeine, the analgesic effect increases.
In the case of simultaneous administration with acetylsalicylic acid, its antiplatelet and anti-inflammatory effects are reduced (in patients who receive small doses of acetylsalicylic acid as an antiplatelet agent, after acute nausea, acute coronary insufficiency may develop with increased frequency).
Manifestations of hematotoxicity of the drug are enhanced by myelotoxic drugs.
In the case of simultaneous application of Novigan with cefoperazone, valproic acid, cefamandole, cefotetan or plikamycin, the frequency of hypoprothrombinemia increases.
Gold preparations and cyclosporin increase the effect of ibuprofen on synthesis in the kidneys of PG, the effect of which is manifested in increased nephrotoxicity. Plasma concentrations of cyclosporine, as well as the likelihood that its hepatotoxic effects will develop, are increased by ibuprofen.
Drugs that block tubular secretion, increase the plasma concentration of ibuprofen, and lower its excretion.

Terms of sale

The drug is dispensed in pharmacies without a prescription.

Storage conditions

Novigan should be stored out of reach of children in a dry, dry place. The storage temperature should not exceed 25 ° C.
Shelf life - 5 years.

special instructions

In the case of long-term use of the drug, careful monitoring of the picture of the functional state of the kidney and liver and peripheral blood is required.
To reduce the risk of developing adverse events for the gastrointestinal tract, the minimum effective dose of the drug should be taken. In case of symptoms of gastropathy careful monitoring is required, which includes the analysis of feces for the presence of hidden blood, a blood test, which includes the determination of hematocrit and hemoglobin, as well as the conduct of esophagogastroduodenoscopy.
If 17-ketosteroids are required, the drug should be discontinued 48 hours before the start of the study.
During treatment, Nouvigan should refrain from drinking alcohol.
Patients taking the drug should refrain from potentially dangerous activity, which requires the speed of psychomotor reactions and increased concentration of attention (vehicle management, etc.).

Newborns

The drug is contraindicated for infants up to 4 months of age.

With alcohol

During the course of treatment with Novigan, one should refrain from drinking alcoholic beverages.

In pregnancy and lactation

During pregnancy, the drug is contraindicated (especially should be refrained from use in the first trimester and in the last six weeks of pregnancy), and it is not recommended to take Novigan during breastfeeding.

Reviews about Novigan

Most often this drug is taken by girls during spasms during menstruation. At the same time, it is noted that the drug perfectly copes with the task set before it, the difference is only in time, after how much the medication begins to work: one it helps for literally 10-20 minutes after administration, and some wait for the effect for about an hour. But still most people note the effectiveness of Novigan tablets.
What helps the drug also, so it's from a headache. Although there are such reviews, which say that the migraine drug did not help. But nevertheless, it is often noted that it is effective in all types of pain, including headaches.
Also, some say that after the application, pulling pains in the heart area begin, although such feedback units - usually everything happens without side effects.
There are a lot of reviews on the web, from which Novigan tablets, but there are also a lot of fears about those side effects that go "in the makeweight" to the benefits that the formulation gives. But most still notes that these were baseless fears - most often no side effects were observed when taking.