Pentalgin tabs #24

Pentalgin instruction for use

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Composition of Pentalgin

The composition of the Pentalgin tablets contains active components: paracetamol, caffeine, naproxen, phenyramine maleate and drotaverine hydrochloride.
Additional components: microcrystalline cellulose, croscarmellose sodium, potato starch, giprolose, citric acid, butylhydroxytoluene, titanium dioxide, magnesium stearate, talc, indigocarmine, hypromellose, povidone, polysorbate 80, dyes.

Form of issue

Produced Pentalgin in the form of tablets, which are covered with a film membrane of green color for 2, 6, 10 and 12 pieces in a cell pack of 1-2 in a pack.

Mnn

Caffeine + Drotaverin + Naproxen + Paracetamol + Pheniramine maleate

pharmachologic effect

The medicine has analgesic, antipyretic and anti-inflammatory action.

Pharmacodynamics and pharmacokinetics

This combined preparation shows analgesic, anti-inflammatory, antispasmodic and antipyretic effect. In this case, the therapeutic effect of Pentalgin is due to the constituent substances.
For example, as Wikipedia points out, paracetamol is an analgesic-antipyretic that exerts an antipyretic and analgesic effect, which is ensured by blockade of COX in the nervous system and influence on pain centers and thermoregulation.
Caffeine is a psycho-stimulating substance that promotes the expansion of blood vessels in skeletal muscles, heart and kidneys. In addition, mental and physical performance is increased, fatigue and drowsiness are eliminated, the permeability of histohematological barriers is increased, as well as the bioavailability of non-narcotic analgesics, helping to enhance the therapeutic effect. A toning effect, reflected on the vessels of the brain, was noted.
Naproxen is an NSAID that exhibits anti-inflammatory, antipyretic and analgesic effects, which is associated with a nonselective suppression of COX functions regulating the production of prostaglandins.
For drotaverina is characterized by myotropic spasmolytic effect, which is due to inhibition of PDE 4, affects the smooth muscles of the gastrointestinal tract, vessels, organs of the genitourinary system and bile ducts.
The histamine H1 receptor blocker substance - phenyramin - shows spasmolytic and mild sedative effect, reduces exudation, enhances the analgesic effect of paracetamol and naproxen.

Indications for use

The main indications for use:
    various types of pain syndromes, for example, radiculitis, articular, muscle pain, with menstruation, neuralgia, algodismenorea;
    pain with spasm of smooth muscles, caused by chronic cholecystitis, cholelithiasis, renal colic, postcholecystectomy syndrome;
    post-traumatic and postoperative pain, including inflammatory conditions;
    colds with febrile syndrome.
Also, the drug is used as a medicine for toothache, migraines.

Contraindications

There are various contraindications to the use of Pentalgin:
    erosive and ulcerative disorders of the gastrointestinal tract;
    bleeding GIT;
    intolerance of its components;
    bronchial asthma, recurrent nasal polyposis and paranasal sinuses, intolerance to acetylsalicylic acid and other NSAIDs;
    severe forms of hepatic and renal insufficiency;
    processes that inhibit bone marrow hematopoiesis;
    aortocoronary bypass surgery;
    hyperkalemia;
    diseases of the cardiovascular system;
    severe arterial hypertension;
    age younger than 18 years.
Contraindicated in pregnancy and lactation. Therefore, if there are pain or other disorders during pregnancy, you need to get an appointment for a suitable treatment from a doctor.
A number of conditions have also been noted when the drug is administered with extreme caution, for example, with: cerebrovascular diseases, diabetes, peripheral arterial diseases, benign hyperbilirubinemia, peptic ulcer lesions, renal and hepatic insufficiency of mild and moderate form, viral hepatitis, liver damage with alcohol, epilepsy and propensity to seizures, old age, deficiency of glucose-6-phosphate dehydrogenase and so on.

Side effects

In the treatment of pentalgin, unwanted effects can develop, for example, allergic reactions, disorders of the nervous, cardiovascular, digestive, genitourinary and hematopoiesis, as well as sensory organs.
It can be accompanied by such symptoms as: itching, skin rash, urticaria, angioedema, thrombocytopenia, agranulocytosis, leukopenia, anemia, methemoglobinemia, agitation, anxiety, tremor, headache, sleeping problems, dizziness, heartbeat, arrhythmia, increased blood pressure , pain, erosive and ulcerative disorders of the digestive tract, nausea, vomiting, constipation, abnormalities in the work of the kidneys, hearing loss and so on.
Pentalgin tablets, instructions for use (Method and dosage)
Detailed instructions for the use of Pentalgin indicates that the tablets are administered orally once a day 1-3 times a day. The maximum daily dosage is no more than 4 tablets.
The duration of treatment is determined by the violation. For example, as an antipyretic tablet Pentalgin green take up to 3 days, as an anesthetic - up to 5 days. If you need to increase the duration of therapy, you should consult your doctor.

Overdose

In cases of the use of tablets, overdose can occur over a long period in high doses, accompanied by symptoms: pallor of the skin, anorexia, abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, anxiety, confusion, tachycardia, arrhythmia, hyperthermia, increased urination, pain, tremor, epileptic seizures and so on.
More severe forms of overdose are: development of hepatic insufficiency with increasing encephalopathy, arrhythmia, pancreatitis, coma, fatal outcome.
Usually treatment includes: gastric lavage, intake of activated charcoal, administration of a specific antidote - acetylcysteine ​​or other drugs, depending on the symptomatology.

Interaction

The use of pentalgin with barbiturates, tricyclic antidepressants, Rifampicin increases the risk of hepatotoxic effect. Also, this drug is able to strengthen the effect of anticoagulants of indirect effects and reduce the effectiveness of uricosuric medicines.
The continued use of barbiturates reduces the effectiveness of paracetamol. While inhibitors of microsomal oxidation, for example, cimetidine, can reduce its hepatotoxic effect.
Simultaneous application with diflunizal can increase the concentration of paracetamol in the plasma by 50%, increasing the development of hepatotoxicity.
It has been established that naproxen reduces the diuretic effect of Furosemide, strengthening the effect of indirect anticoagulants, increasing the toxicity of sulfonamides, methotrexate, and also reducing the excretion of lithium and increasing its content in the blood plasma.
Joint intake of caffeine with barbiturates, primidone, anticonvulsants often increases metabolism and increases the clearance of caffeine. The combination of caffeine with cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - reduces the metabolism of caffeine.
With the simultaneous use of caffeinated drinks and other drugs that can stimulate the nervous system, it causes excessive stimulation. Drotaverin markedly weakens the antiparkinsonian action of Levodopa. The use of Pheniramine and tranquilizers, hypnotics, MAO inhibitors, can enhance the depressing effect on the nervous and other systems.

special instructions

It is contraindicated with Pentalgin to take other medicines containing paracetamol and NSAIDs. With care appoint funds designed to alleviate cold symptoms, nasal congestion and influenza.
If the patient takes this drug for more than 7 days, monitoring of peripheral blood and liver function is necessary.
The ability of paracetamol to distort the results of laboratory studies associated with the content of glucose and uric acid in the blood plasma is noted.
When it is necessary to determine 17-ketosteroids, the drug is canceled 2 days before the study. It should be remembered that naproxen may increase the time of bleeding.
The effect of caffeine on the nervous system is dependent on its type and can manifest itself either by excitation or inhibition of nervous activity.

Terms of sale

To buy Pentalgin you don't need a prescription.

Storage conditions

For the storage of these tablets, a dry and dark place is unavailable for children, at temperatures up to 25 ° C.
Shelf life - 2 years.

Pentalgin and Alcohol

During treatment it is forbidden to drink alcohol. The fact is that the simultaneous use of paracetamol with ethanol increases the risk of developing acute pancreatitis.

Reviews about Pentalgin

As you know, various painkillers are very popular in the society. A special need for them arises in people who are afraid or simply do not like to visit a doctor. Therefore, they manage with handy tools, and to eliminate pain, they take Analgin, No-shpu, Pentalgin and Pentalgin-N. According to reviews, these drugs have different effects on different people.
In most cases, reviews about Pentalgin are associated with its use by women during menstruation, if they are concerned about strong pain. Also these green tablets help a lot for a while to get rid of dental and headaches. On medical forums, there are lengthy discussions on the topic: from what does Pentalgin help the best? Often, patients compare the effect of this drug and other types of it, for example, Pentalgin FS, which helps many people to eliminate muscle pain.
In this case, experts do not get tired to specify what Pentaglin tablets are, what they help with when and how long they can be taken. The fact is that any pain sensations already indicate that the body has failed, and therefore he needs professional help. However, most people in such cases do not hurry to the doctor, but begin to look for ways to eliminate pain. You should be aware that this approach often complicates the course of the disease, the treatment of which will eventually require more intervention and time.