Carsil forte caps 90mg #30

Carsil forte instruction for use

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Composition

Extract of the milk thistle powder, lactose monohydrate, microcrystalline cellulose, talcum powder, wheat starch, povidone, glucose monohydrate, sodium hydrogen carbonate, magnesium stearate, sorbitol.

Form of issue

Capsules gelatinous 90 mg of light brown color in a blister pack of 6 capsules in carton No. 30.

pharmachologic effect

Hepatoprotector.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug, based on the extract of thistle fruits, which contains a mixture of isomers of flavonolignans (silibinin, silidianin, iso-silibinin and silicristin), has a hepatoprotective effect. The mechanism of action of silymarin is based on a competitive effect with toxins on the hepatocyte receptors. Silymarin regulates cell metabolism and permeability of the cell membrane and binds to free oxygen radicals. The drug stimulates the synthesis of structural proteins and phospholipids in hepatocytes affected by the virus, accelerates regeneration processes. The effect of flavonoids is largely due to antioxidant effects and improvement of microcirculation processes. Clinically, this is manifested by normalization of liver function, improvement in the general condition of the patient.

Pharmacokinetics

The drug has a slow absorption, does not accumulate in the body. The maximum concentration of silibinin is found in the liver and slightly - in the heart, kidneys, lungs. Metabolised in the liver in the form of sulfates and glucuronides. Output is 80% with bile, the half-life is about 6 hours.

Indications for use

Treatment of liver damage of toxic origin, non-viral chronic hepatitis, conditions after acute hepatitis, cirrhosis and steatosis of the liver.
It is also prescribed for the prevention of liver damage with alcohol abuse, long-term medication, severe chronic intoxication.

Contraindications

Individual hypersensitivity to Carsil Forte, galactosemia, lactase deficiency, age to 12 years, pregnancy and lactation period.
Assign with caution in the presence of hormonal disorders (uterine fibroids, ovarian cancer, prostate and breast cancer).

Side effects

Dyspepsia, nausea, diarrhea, local allergic reactions, vestibular disorders. Side effects, as a rule, after the termination of reception Karshila completely disappear.

Instructions for use Carsil Forte (Method and dosage)

Adults and children after 12 years for the treatment of severe liver diseases are prescribed 1 capsule orally, washed down with water 3 times a day and 1 capsule 2 times a day for mild and moderate severity of lesions. Take the drug is recommended for 3 months.
The instruction on Carsil Fort points to the necessity of preventive administration of the drug 1 capsule per day with the potential for the development of drug and chemical intoxication.

Overdose

There is no evidence of an overdose of the drug.

Interaction

Carsil Forte enhances the effect of a number of drugs (Diazepam, Vinblastine, ketoconazole, Alprazolam, Lovastatin).
When the appointment of silymarin together with oral contraceptives, there is a decrease in the effectiveness of their action.

Storage conditions

In a dry place at a temperature of up to 25 ° C.
Shelf life - 2 years.

Reviews about Carsil Forte

Reviews about the drug are favorable:
    "... Excellent medicine, while natural and much cheaper than analogues. Took more expensive drugs, but the effect is the same, so why overpay. After taking Carsil Forte, my health improves, in the right hypochondrium discomfort disappears, bitterness disappears in the mouth. "
Many of the members of the forum write that they take the drug for prophylactic purposes after the holidays, which are accompanied by a rich intake of food and alcohol.
Carsil Forte, doctors' reviews: the drug is effective in the treatment of acute and chronic hepatitis, chronic cholecystitis, dyskinesia of the gallbladder. It is prescribed for cirrhosis of the liver and hepatitis to prevent the progression of the negative process.