Lеgalon 140 caps #60

Lеgalon user manual

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Composition

    1 capsule Legalon 70 contains the active substance - dry aging of the milk thistle fruit spotted 86.5-93.35 mg, which corresponds to the content of 70 mg of silymarin; auxiliary substances - povidone, polysorbate 80, mannitol, sodium carboxymethyl starch, magnesium stearate; composition of the capsule: gelatin, red oxide, titanium dioxide, sodium lauryl sulfate, black oxide.
    1 capsule Legalon 140 contains 173-188.7 mg of dry extract from the fruit of the milk thistle, which corresponds to 140 mg of silymarin; The auxiliary substances and the composition of the capsule are the same as in Legalon 70 capsules.
Form of release Legalon 70
    capsules gelatinous hard brown in 10 capsules in a blister; in a cardboard bundle for 2, 3 or 6 blisters (20, 30 or 60 capsules each);
    20 drops of pills in a cardboard package.
Form of release Legalon 140
    capsules gelatinous hard brown in 10 capsules in a blister; in a cardboard bundle 2, 3 or 6 blisters (20, 30 or 60 capsules each).

pharmachologic effect

The drug has the following pharmacological action:
    hepatoprotective - protects liver cells (hepatocytes) from destruction and toxic effects;
    regenerating - promotes the regeneration of liver cells;
    detoxifying - clears the liver of toxins, including free radicals (antioxidant effect);
    Anti-inflammatory - suppresses inflammatory processes in the liver.

Pharmacodynamics and pharmacokinetics

Legalon is a herbal preparation, the active substance in it is a dry extract of the milk thistle fruit. Included in the extract of the milk thistle silymarin is a plant antioxidant complex that has a healing effect on the liver. In the milk thistle, many biologically active substances have been discovered, including several species of silymarin and the isomer of silimarin silibinin, which have a hepatoprotective effect.
The action of silymarin and its isomers is based on their antioxidant properties. They suppress lipid peroxidation, which prevents the destruction of membranes of hepatocytes. Silymarin helps to restore hepatocytes by activating the action of intracellular enzymes. It stimulates the intracellular formation of proteins and phospholipids, which are the main components of cell membranes. The strengthening of membranes promotes the preservation and rapid recovery of hepatocytes.
Silymarin does not allow the entry into the hepatocytes of certain hepatotoxic poisons, for example, poison fungus pale toadstool. In addition, silymarin inhibits the formation of prostaglandins - the main components of the inflammatory process, that is, it has an anti-inflammatory effect.
Restoration of the cellular metabolism is promoted by the tocopherols, mineral substances (potassium, magnesium, copper, selenium), unsaturated fatty acids contained in the fruits. The latter actively promote the oxidation of cholesterol, which prevents the spread of atherosclerosis.
Biologically active substances of thistle fruits also have a positive effect on the gastrointestinal tract, the processes of digestion and the formation of bile.
After the course of treatment with Legalon in patients with liver diseases, the general condition improves, including less worried about weakness, pain in the right hypochondrium, vomiting, pruritus, anorexia, etc. Simultaneously, laboratory indicators are also improving, which speak of the state of liver function.
It is impossible to establish completely the process of promoting Legalon in the human body, since it contains too many biologically active substances. But it is established that after taking Legalon, its concentration in the blood plasma reaches a maximum in half an hour.
The main part of the drug is secreted with bile in the form of metabolic products. Maximum excretion with bile is achieved after 2 hours. As a result of interaction with the intestinal microflora, almost half of the silymarin released from the bile is re-absorbed in the intestine, forming an intestinal-hepatic circuit.

Indications for Legalon

The drug is prescribed for the following diseases and conditions:
    after the transferred infectious or toxic hepatitis, liver injuries;
    at toxic (including alcoholic) and medicinal lesions of a liver;
    with chronic hepatitis of any origin;
    with exchange-dystrophic liver diseases, including those with fatty hepatosis;
    with cirrhosis of the liver - prolonged use of Legalon inhibits the progression of cirrhosis;
    with diseases of the bile duct and gall bladder of any origin;
    with chronic pancreatitis and after acute pancreatitis;
    at violations of fat metabolism, hyperlipoproteinemia and atherosclerosis - a long reception of Legalon inhibits the spread of these disorders;

Contraindications for the use of Legalon

Hypersensitivity to the drug components

Side Effects of Legalon

The drug is well tolerated by patients. Of the side effects of Legalon, only a small laxative effect is known, which is rare enough.

Legalon - instructions for use

Capsules and dragees are taken orally, swallowed whole, washed down with water. Reception of Legalon is not associated with food intake. The dosage of the drug, the frequency of its administration during the day, the duration of the course of treatment is determined by the attending physician, depending on the condition and age of the patient.
Instruction for Legalon 70: the drug is taken for 1 - 2 capsules twice or thrice a day. With a long course of treatment, the drug should be taken twice a day. Children, depending on their age and general condition, are prescribed half or one capsule three times a day. With a long course of treatment, the drug should be taken twice a day in the same dosage.
Instructions for use Legalon 140: the drug is taken 1 capsule twice or thrice a day. With a long course of treatment, the drug should be taken twice a day.
The standard course of treatment is at least 12 weeks, but it can last for several months.

Interaction of Legalon with other medications

The drug is perfectly combined with other medicinal substances. But there is evidence that it is an antagonist of certain drugs, for example, Yohimbine (a drug for the treatment of impotence) and Fentolamine (a drug from a group of adrenoblockers that dilate the peripheral blood vessels).

Terms of sale

The drug is dispensed in a pharmacy without a prescription.

Storage conditions

Capsules and dragees should be stored in a dark place at a temperature of no higher than 30 ° C. The drug should not be available to children.
Shelf life - 5 years

Reviews about Legalon

Reviews about this drug are mostly positive: with prolonged use, the condition of patients is steadily improving. Reviews for Legalon 140 suggest that a large dosage of the drug in most cases justifies itself. The doctors' comments are all positive - the drug is effective, both in the complex treatment and in the form of monotherapy.
Negative reviews of this drug are very few. But if you go to the forum, you can find them. In general, negative reviews are associated with the fact that when taking Legalool there is no immediate therapeutic effect. Indeed, it is a herbal preparation, so it acts slowly.