Essentiale N solution 250mg/5ml 5ml #5

Essentiale N instruction

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See also -Essentiale Forte N

Composition

Essentiale N: EPL substance - Essentiale phospholipids of soybean beans (93% (3sn-phosphatidyl) choline) at a concentration of 50 mg / ml, benzyl alcohol, deoxycholic acid, sodium hydroxide, sodium chloride, food supplement E101 (riboflavins), water q /and.

Form of issue

Injection solution 50 mg / ml, ampoule 5 ml, package number 5. The solution is clear, yellow, and there are no visible suspended particles.

pharmachologic effect

Promotes increased liver resistance to pathological effects and enhances its detoxifying properties.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Membranes and organelles of liver cells are always affected by organ pathologies, which can lead to a change in the activity of membrane-bound enzymes and receptor systems, disruption of the metabolic function of hepatocytes and a decrease in the intensity of organ regeneration.
The EPL-substance in the Essentiale N formulation resembles endogenous phospholipids in its chemical structure, but it is much superior to the latter due to the high content of PUFA.
Embedding mainly in the structure of cell membranes, these high-energy molecules contribute to the restoration of damaged liver tissue.
Cis-double bonds PUFA do not give hydrocarbon chains in the phospholipids of the cell membranes to be located in parallel, as a result of which the phospholipid structure of the hepatocyte membranes becomes more friable. This causes an increase in their elasticity and fluidity, as well as an increase in the rate of entry of substances into the cell and their removal from it.
Membrane-bound enzymes form functional blocks that can enhance their activity and provide a physiological flow of the basic metabolic processes.
Phospholipids by regulation of lipoprotein metabolism affect the impaired metabolism of lipids, facilitating the biotransformation of cholesterol and neutral fats in transportable forms and their transfer to oxidation sites. This is realized primarily by increasing the ability of HDL to bind to cholesterol.
When phospholipids are eliminated through the biliary tract, a decrease in the lithogenicity index and bile stabilization are noted.

Pharmacokinetics

When taken orally, about 90% of the dose is absorbed in the small intestine. The main part of the EPL-substance under the influence of phospholipase-A is cleaved to 1-acyl-lysophosphatidylcholine, half of which is immediately reacylated to polyunsaturated phosphatidylcholine (PFC) even when absorbed in the small intestine.
PFH enters the bloodstream through the lymphatic ways and further, mainly with LP of high density, is transported to the liver.
In order that the concentration of phosphatidylcholine in the blood (on average 20%) reaches a maximum, it takes from 6 to 24 hours. The semi-elimination period for saturated LC-32, for the choline component - 66 hours.
In studies of the pharmacokinetics of the drug, it was found that less than 5% of each of the 14C and 3H isotopes introduced is excreted with the intestinal contents.

Indications for use

Indications for the use of Essentiale (INN - Mono):
    steatohepatitis (alcoholic or non-alcoholic);
    hepatitis (any form of clinical course and etiology);
    cirrhosis of the liver;
    radiation syndrome;
    pre- and postoperative treatment for surgical interventions in the hepatobiliary zone;
    psoriasis;
    Toxicosis of pregnant women.

Contraindications

Contraindication to the prescription of the drug is hypersensitivity to any of its components.
It is strictly forbidden to administer the solution to newborns and premature infants (contraindication is due to the fact that Essentiale N contains benzyl alcohol).

Side effects

The use of high doses Essentiale N may be accompanied by disorders of the digestive tract (in particular, diarrhea).
Individual patients experienced hypersensitivity reactions, urticaria, pruritus, rash and reactions at the site of administration of the solution.

Ampoules Essentiale: instructions for use

According to the instructions for use Essentiale N, the standard dose of medication for patients over 12 years is 5-10, in severe cases, up to 20 ml / day. (10 ml of the solution can be administered once).
To dilute the drug is recommended to use the patient's blood in a ratio of 1: 1. Intravenously, the drug is infused for up to 10 days.
Parenteral therapy is tried as early as possible to supplement (support) the appointment of Essentiale capsules.
The course of treatment usually lasts from 3 months to 6 months.

How to take the drug with psoriasis?

In psoriasis, treatment begins with the use of Essentiale Forte N in a dose of 1.8 g / day. (6 capsules). Treatment lasts 2 weeks, after which the patient is prescribed PUVA-therapy and Essentiale N injections (10 doses of 5 ml intravenously).

Application Essentiale in ampoules for hair

Essentiale hair is used in cases where it is required to strengthen their weakened root bags.
The basis of the drug are fat-soluble substances, so the mask for hair with Essentiale should be prepared on sour cream, kefir or egg yolks.
For short hair, usually a third of the volume of 1 ampoule solution is sufficient, for long - half. The medicine is typed with a syringe and mixed with 1 egg yolk of a chicken egg and 1-2 teaspoons of sour cream / kefir.
Apply the mixture on clean, damp hair. The duration of exposure is 60 minutes. After this time, the composition is washed off with warm water. Dry hair is recommended without a hairdryer. The first 5 masks are done once a week, in the future, to maintain the effect, it is enough to repeat them once a month.
To enhance the effect, Dimexide can be added to the mask.

Overdose

There is no information on cases of overdose.

Interaction

Solutions of electrolytes (for example, Ringer's solution or saline NaCl) can not be used to dilute the drug.

Storage conditions

Ampoules should be stored at a temperature of 2-8 ° C. List B.
Shelf life - three years.

special instructions

If Essentiale N is infused with a dropper, in cases where the patient's blood can not be used for any reason, solutions that are free of electrolytes should be used, namely: 5% xylitol solution, 5 or 10% glucose solution in the ratio 1: 1.
Only transparent solution is considered suitable for use.
Do not mix the drug in one syringe with other drugs.
Essentiale I / O should be administered very slowly. The solution is intended exclusively for intravenous infusion, injections into the muscle can provoke local irritation.
The solution contains 0.6% alcohol (by volume).

What is the difference between Essentiale N and Essentiale Forte N?

Essentiale N and Essentiale Forte N are different forms of the same medicine. Essentiale Forte N is available in the form of capsules, each containing 300 mg of EPL substance.
Unequivocally answer the question, which is better - Essentiale or Essentiale Fort - it is impossible. The choice in favor of this or that dosage form is made taking into account indications for use (for example, in case of toxicosis of pregnant women, it is preferable to take capsules, since alcohol is contained in the solution).
In this case, capsules are often used as an adjunct to parenteral therapy.

Ovesol or Essentiale - which is better?

The basis of Ovesol are extracts of mint, oats, immortelle, turmeric. The main difference between it and Essentiale is that it is not a medicinal product, but a dietary supplement.
The active substances contained in the tablets are very useful for the liver, since they help to cleanse the liver of toxic substances and slags, eliminate stagnation of bile and form concrements.

Ovesol is contraindicated in patients younger than 18 years of age, Essentiale can also be used in adolescents over 12 years of age.
Ovesol treatment is conducted three times a year with courses lasting 3 weeks. Continuous reception of Essentiale capsules is possible within 3-6 months.

Which is better - Essentiale or Phosphogliv?

Active substances of the preparation Phosphogliv (available in the form of capsules and lyophilizate for the preparation of p-ra d / i) are phospholipids and glycyrrhizic acid (glycyrate). Their content in the capsules, respectively, 65 and 35 mg, in the lyophilizate - 500 and 200 mg.
Glycyrate refers to steroid saponites derived from licorice root extract (licorice). His molecule contains a fragment whose structure is similar to the structure of hormones produced by the adrenal cortex.
In this regard, the long (more than 6 consecutive weeks) use of glycyrate, as well as the use of the drug in a dose exceeding the therapeutic, provokes the development of serious adverse reactions.
With prolonged use of glycyrrhizic acid, patients experience symptoms of intoxication: hypertension, headache, edema, hypokalemia, lethargy, cardiac arrest.
Side effects are similar to those caused by corticosteroid drugs and are due to the fact that glycyrate inhibits the breakdown of endogenous hormones in the adrenal cortex.
The advantages of Essentiale N include a higher concentration of phospholipids in it, as well as the fact that only one substance is included in the drug as an active substance, which is why the treatment with the drug is rarely accompanied by undesirable reactions.

What is better - Essentiale or Hepabene?

The hepatoprotective effect of the drug Hepabene is due to the properties of the extracts of thistle and herb medicinal herbs.
Milk thistle contains bioflavonoid silymarin, which has a hepatoprotective effect in toxic liver damage, and also exhibits membrane-stabilizing properties and promotes the recovery of hepatocytes.
The alkaloid fumarin, contained in the grass of the fumigant, stimulates the secretion of bile and reduces the tone of the sphincter of Oddi.
Thus, the use of Hepabene is useful in chronic liver diseases, especially if they are accompanied by stagnation of bile.

For children

Since one of the components of Essentiale N is benzyl alcohol, the solution can not be used in newborns and premature infants.
The introduction of benzyl alcohol-containing drugs to newborn / premature infants was accompanied by the development of a gasping syndrome (fatal asphyxia syndrome) -a severe condition with respiratory depression, purpura, metabolic acidosis, encephalopathy, arterial hypotension, severe suffocation, hemorrhages to various organs (brain, kidneys, adrenal glands, liver, heart) due to hypoxia.
"Syndrome of dyspnea" in children ends in a fatal outcome (cause of death - cardiovascular collapse).
In pediatrics, the drug is used to treat children older than 12 years with a weight of 43 (or more) kg.

Essentiale and alcohol

Alcohol and Essentiale N are not compatible.

Why Essentiale during pregnancy?

During pregnancy, capsules are used Essentiale. The drug is often prescribed when it is necessary to eliminate the manifestations of early toxicosis or signs of gestosis.
Especially indispensable medicine for gestosis. Late toxicosis can seriously harm the development of the child, the same Essentiale helps promote the normal assimilation of the necessary micronutrients and valuable substances and, thus, ensures the proper development and normal weight gain.
Essentiale allows you to prevent liver problems in women who have jaundice before pregnancy, and also helps to normalize metabolic processes in the presence of violations of the placental circulation.
In some cases, the taking of capsules continues in the postpartum period, especially if the course of labor was severe.
With the proper use of Essentiale, not only all liver functions are normalized, but also the work of the organism as a whole. In this case, the drug is completely safe for both the future mother and her child.

Application of the solution during pregnancy

Due to the limited availability of clinical research data on the use of the drug during pregnancy, and because of the presence of benzyl alcohol in the solution, which can pass through the placental barrier, it is not recommended that Essentiale N is administered to pregnant and lactating women.

Reviews about Essentiale N

Reviews of doctors, as well as everyday practice confirm the high efficiency of Essentiale. The drug favorably differs among other hepatoprotectors, and its safety (including during pregnancy) is confirmed by the results of various clinical studies (including double-blind studies).
It is very important that similar studies for most generics Essentiale were not conducted.
The drug is an integral part of the therapy of liver diseases of metabolic and toxic origin, and it is suitable not only for humans, but also for dogs and cats.
The properties of the phospholipids contained in the drug make it possible to use it for hair as a strengthening agent. Reviews of women indicate that the effect of masks with Essentiale is noticeable after the first procedure.