Cocarboxylase powder 50mg #5
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Cocarboxylase user manualReed more and buy Cocarboxylase onlineCompositionOne ampoule with lyophilizate for the preparation of solution includes 50 mg of Cocarboxylase hydrochloride and a solvent (sodium acetate solution) of 2 ml...
Cocarboxylase user manual
Reed more and buy Cocarboxylase online
One ampoule with lyophilizate for the preparation of solution includes 50 mg of Cocarboxylase hydrochloride and a solvent (sodium acetate solution) of 2 ml.
Form of issue
The powder from which the injection solution is prepared, supplied in ampoules of 50 ml, the quantity - 5 pieces in one package.
Cocarboxylase has a coenzyme effect, since it is a coenzyme of thiamine. Together with the protein and ions, magnesium catalyzes the carboxylation and decarboxylation of alpha-keto acids, and also stimulates the formation of acetyl-coenzyme A, thereby normalizing the carbohydrate metabolism.
Pharmacodynamics and Pharmacokinetics
Cocarboxylase is fast and absolutely absorbable if injected parenterally. Basically, absorption occurs in the small intestine and duodenum. Clearance - about 11 hours. The active substance of the drug almost completely penetrates into all tissues, but its greatest concentration is observed in the liver, kidneys, brain and heart.
Transportation in the blood occurs with the help of red blood cells, which contain about 80% of the total amount of Cocarboxylase in the form of thiamine diphosphate. The metabolism of the active substance is carried out in the liver. The drug is excreted from the body with urine in an amount that depends on the dose taken.
Cocarboxylase (Cocarboxylasum) is an active form of vitamin B1, which has a metabolic effect by activating tissue metabolism. Phosphorylated in the body, forming mono-, di- and tri-phosphoric esters. This substance belongs to the group of enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, and also stimulates the formation of acetyl-coenzyme A, due to which it participates in carbohydrate metabolism.
The drug promotes the absorption of glucose and normalizes the function of the CCC. In addition, the substance improves the trophism of the tissue, and, with its lack, there is an increase in the content of pyruvic acid and lactic acid in the blood, which can provoke the development of acidosis and ultimately lead to an acidotic coma.
Assign this medication for diseases accompanied by endogenous insufficiency of Cocarboxylase in combination with vitamin B group.
Indications for use of Cocarboxylase
The described preparation is prescribed for:
metabolic, diabetic and respiratory acidosis;
disorders of carbohydrate metabolism, accompanied by pathological processes;
chronic ischemic heart disease;
diabetic and hepatic coma;
the effects of acute alcohol poisoning;
infectious diseases of various types;
sepsis and other diseases, which are accompanied by hypoxia and acidosis.
Individual intolerance to the active substance.
Side effect of Cocarboxylase has on the body after the administration of a dose exceeding 500 mg per day. There are side effects in the form of the following reactions:
lack of appetite;
pain in the epigastric region;
feelings of anxiety and fear;
acute respiratory failure;
rash on the skin;
Also, side effects can occur in the area of administration of the drug in the form of:
Instructions for use Cocarboxylase
This drug is administered in three ways:
Dosage is prescribed by the doctor individually, depending on the patient's illness and his current condition.
Cocarboxylase, instructions for use
The dosage of the drug depends on the indications for the use of Cocarboxylase. Adults receive intramuscularly 50 to 100 milligrams of the drug per day. According to the doctor's decision, the dose can be reintroduced with a difference of two hours. Usually, this dose increases with diabetic coma with a further transition to maintenance therapy with a dosage of 50 milligrams per day.
Patients with circulatory failure, the drug is administered to a dose of 50 milligrams a day at a frequency of two or three times. The course of treatment can be from two weeks to one month.
Patients with diabetes mellitus drug is administered intravenously in a dosage of 100 to 1000 milligrams per day for five to ten days. In this case, conventional antidiabetic therapy does not stop.
Patients with acute hepatic and renal insufficiency, the drug is administered intravenously in a dosage from 50 milligrams to 150 milligrams three times a day, or the drug is administered drip in a dosage of 100 to 300 milligrams per day with preliminary dissolution of a 5% glucose solution in 400 milligrams.
Patients with peripheral neuritis are given this drug in a dosage of 50 to 100 milligrams per day intramuscularly. The duration of treatment can be 1-1.5 months.
For children up to three months, the drug is administered in the form of subcutaneous or intramuscular injections in a dosage of 25 milligrams per day. Children older than 3 months and up to 7 years of age, the drug is administered in a dosage of 25 to 50 milligrams per day. Children from 8 to 18 years of age, the drug is administered at a dose of 50 to 100 milligrams per day.
Cocarboxylase during pregnancy is prescribed by the course - 10 days to 50 milligrams per day. The powder dissolves in twenty milligrams of glucose. the injection is done iv in a complex with ascorbic acid in the form of a solution.
In pregnancy, Cocarboxylase is prescribed during fetal hypoxia, and also together with complex therapy in the treatment of toxicoses.
If the dose prescribed by the doctor is exceeded, symptoms of overdose may appear in the form of:
violation of the cardiovascular system;
Shortness of breath.
When symptoms of an overdose show, the drug is canceled and mandatory symptomatic treatment is performed.
Interaction with other drugs
Cocarboxylase effectively interacts with a number of drugs and biologically active substances:
antidepressants in combination with the drug - enhanced action;
vitamins of group B - at simultaneous reception of the given preparation the effect of vitamins amplifies;
digoxin - the ability of myocardiocytes to absorb the active substance of the drug and its metabolites decreases;
The use of this drug in combination with solutions with an alkaline or neutral reaction is not recommended.
Terms of sale
You can buy Cocarboxylase without prescription.
Store the drug can be at a temperature of no higher than 25 Celsius in a dry and protected from direct sunlight.
Shelf life of the drug is 3 years. Use of the drug after the expiration date is not recommended.
Reviews of Cocarboxylase
Reviews of the Cocarboxylase can be found on the Internet. The doctors leave reviews in terms of professional observations and patients who have experienced the effect of this medication on themselves.
For example, a practicing physician Nicholas on one of the resources wrote:
"Ivococcalase can have a really effective effect on patients with heart failure. With full compliance with my recommendations, 99% of patients claim that symptoms of unpleasant diseases disappear after 2-3 injections, which already speaks about the benefits of the drug. "
But Natalia, who prescribed the drug during pregnancy, wrote that she had not seen any visible changes, but the analysis after taking the drug showed a marked improvement in the state of health. After birth an analogue of the drug in the form of candles was prescribed for use by her child.
Neutral or negative reviews from patients on the Internet can not be found, which can also be attributed to the obvious merits of this drug.