Famotidine tabs 40mg #30

Famotidine instruction for use

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Composition

Tablets contain the active ingredient famotidine in an amount of 20 or 40 mg.
Additional elements are: starch, magnesium stearate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, talc, as well as titanium dioxide, hydroxypropylmethylcellulose, iron oxide, macrogol 600.

Form of issue

Pills.

pharmachologic effect

The blocker of histamine H2-receptors. Has antiulcer effect.

Pharmacodynamics and pharmacokinetics

The active component inhibits the production of basal hydrochloric acid in the stomach, as well as stimulated by acetylcholine, histamine and gastrin HCl. Reduces the activity of pepsin, increases the pH of gastric juice, reduces the production of HCl.
Thanks to the increase in the level of glycoproteins, the increase in the formation of gastric mucus, the stimulation of the synthesis of prostaglandins, the secretion of bicarbonate, the protector and wound-healing effect of the drug is achieved.
The drug helps to stop gastric bleeding, promotes healing of lesions on the stomach mucosa, cicatrizes stress ulcers.
The drug has a weak effect on the oxidase system of the enzyme cytochrome P450 in the hepatic system (overwhelming effect).
The drug begins its activity in an hour, lasts 12-24 hours. With intravenous administration of solutions with the active substance, famotidine, the effect is recorded in half an hour. A single dose leads to suppression of secretion for 10-12 hours.

Indications for use Famotidine

From what tablets?
The medication is prescribed for hyperacidity of gastric juice, ulcerative damage to the digestive system, stress ulcers, symptomatic ulcers, Zollinger-Ellison syndrome, NSAID-gastropathy, erosive variant of reflux esophagitis, heartburn, to prevent recurrences of bleeding after surgery for the digestive system, polyendocrine adenomatosis, systemic mastocytosis.
What are the other indications for famotidine? The drug is prescribed for the prevention of aspiration of gastric juice in patients who are given general anesthesia. The drug is effective in diarrheal disorders. The drug is prescribed for the prevention of aspiration pneumonitis.

Contraindications

Famotidine is not prescribed for breastfeeding, intolerance to the components, during pregnancy.
With cirrhosis of the liver with concomitant portosystemic encephalopathy, with pathology of the kidneys, liver system, in pediatrics appoint with caution.

Side effects of Famotidine

Digestive tract: epigastric pain, dry mouth, nausea, decreased appetite, vomiting, increased liver enzymes, acute pancreatitis, mixed hepatitis, hepatocellular hepatitis, cholestatic hepatitis.
Sense organs: ringing in the ears, paresis of accommodation, blurred vision.
Genitourinary system: decreased libido, amenorrhea, gynecomastia, hyperprolactinemia.
Agranulocytosis, allergic reactions, tremor, drop in blood pressure, dizziness, asystole, AV blockade, bradycardia, anaphylactic shock, bronchospasm, myalgia, arthralgia, hallucinations can develop.

Famotidine, instructions for use (Method and dosage)

Instructions for use of famotidine in tablets

Is taken internally.
With ulcerative lesions of the digestive system: 0.02 grams twice a day or 0.04 grams before bedtime. In some cases, the amount of the drug is increased to 80-160 mg. Duration of therapy 4-8 weeks.
In order to prevent recurrences of ulcerative lesions, once a day, 0.02 grams per night is prescribed.
The initial dose for Zollinger-Ellison syndrome is 20-40 mg 4 times a day, it is possible to increase the dose to 24-48 mg.
Prevention of aspiration of stomach contents: 0.04 grams; before a surgical procedure take 2 hours before the operation. With reflux-esophagitis: twice a day for 0.02 grams.

Preparations with famotidine solution

Intravenously injected slowly 2 minutes: 20 mg every 12 hours. For the prevention of aspiration pneumonitis: intramuscularly 0.02 grams before surgery, or on the morning of the day of surgery.
Powder for injection is dissolved in sodium chloride 0.9% 5-10 ml.

Overdose

It manifests as tremor, collapse, motor excitement, a drop in blood pressure, vomiting.
It requires hemodialysis, asymptomatic therapy.

Interaction

Famotidine inhibits the metabolism of diazepam, aminophenazone, phenazone, lidocaine, caffeine, tricyclic antidepressants, phenytoin, indirect anticoagulants, aminophylline, metronidazole, metoprolol, buformin, glipizide, theophylline, metoprolol, clavulanic acid in the liver.
When taking drugs that depress the bone marrow increases the risk of developing neutropenia. Famotidine reduces the absorption of ketoconazole, itraconazole.
Sucralfate and antacids slow the rate of absorption. Famotidine is compatible with a solution of sodium chloride, dextrose. The drug increases the absorption of clavulonic acid, amoxicillin.

Storage conditions

In a dark, dry place inaccessible to children at a temperature of 15-25 degrees Celsius.
Shelf life is not more than three years.

special instructions

Admission Famotidine can mask symptoms that indicate carcinoma in the stomach. It is recommended to exclude malignant neoplasms of the digestive tract before prescribing the drug.
The drug should be canceled gradually to prevent the syndrome of "bounce". With stress, prolonged therapy, it is possible to develop a bacterial infection in the stomach, the further spread of microbes is not ruled out.
Famotidine should be taken two hours after the application of ketoconazole, itraconazole to prevent their hyperabsorption.
When carrying out skin reactions to histamine, it is important to consider that the histamine receptor blocker can suppress the reaction and lead to a false negative result.
Treatment implies the exclusion from the diet of foods that irritate the gastric mucosa.

Reviews of Famotidine

Inexpensive and effective medicine used for problems with the gastrointestinal tract. Helps with ulcers, gastritis.
In negative reviews of Famotidine there are complaints of side effects and contraindications.

Terms of sell

To buy Famotidine you don't need a prescription.