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Furazolidone tabs 50mg #20

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  • $6.75
  • 3 or more $6.50
  • Availability:In Stock

Furazolidone instructionYou can buy Furazolidone tablets onlineCompositionIn 1 tablet furozolidone 0.05 g.The composition also includes potato starch, calcium stearate, sucrose, polysorbate, lactose.Form of issuePloskotsilindriche..

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Furazolidone instruction

You can buy Furazolidone tablets online

Composition

In 1 tablet furozolidone 0.05 g.
The composition also includes potato starch, calcium stearate, sucrose, polysorbate, lactose.

Form of issue

Ploskotsilindricheskie tablets 0.05 g.
Granules for the preparation of suspension (for children).

pharmachologic effect

Antiprotozoal, antimicrobial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Furazolidone is an antimicrobial agent derived from nitrofuran. Highly sensitive to it are salmonella, shigella, campylobacter, as well as protozoa (lyabmly, trichomonads) and cholera vibrio. Depending on the concentration has a bactericidal or bacteriostatic effect.
The mechanism of action is the blockade of many enzyme systems of the microorganism. Nitrofurans violate cellular respiration, inhibit the Krebs cycle, and block the biosynthesis of nucleic acids. As a result, the shell of microorganisms or their cytoplasmic membrane is destroyed. Under the action of the drug, the destroyed microbial cells release less toxins. Unlike other antimicrobial agents, they activate the immune system.
It works on strains resistant to some antibiotics. Does not affect anaerobes and Pseudomonas aeruginosa. Stability of microorganisms to the drug occurs rarely.
What is Furazolidone used for? Since it is poorly absorbed in the digestive tract and at the same time high concentrations are created in the gut, it is used for intestinal infections of bacterial and protozoal etiology. In contrast, Furadonin has a low toxicity.

Pharmacokinetics

It is well absorbed when taken orally. It is distributed in tissues and liquids. In liquor with meningitis, the same concentrations are created as in plasma, therapeutic concentrations are also achieved in the lumen of the intestine. Intensively metabolized in the liver to an inactive metabolite. It is excreted by the kidneys (up to 65%), minor amounts are determined in feces,

Indications for use of Furazolidone

    dysentery;
    giardiasis;
    cholera;
    paratyphuses;
    food poisoning;
    Trichomonas colpitis and urethritis;
    pyelitis;
    cystitis;
    local treatment of infected wounds and burns.

Contraindications

    hypersensitivity;
    pregnancy, breast-feeding;
    renal failure (terminal stage);
    severe hepatic impairment;
    age up to 3 years (tablets);
    age up to 1 month. (suspension).
With caution is prescribed for diseases of the nervous system and deficiency of glucose-6-phosphate dehydrogenase.

Side effects

    skin rash, skin itching, Quincke's edema;
    decreased appetite;
    pulmonary edema, bronchospasm (with prolonged use);
    nausea, vomiting;
    hepatotoxic effect;
    neuritis (with prolonged use).
The risk of peripheral neuropathy is increased in diabetes mellitus, hypovitaminosis B and C, anemia.

Furazolidone tablets, instructions for use (Method and dosage)

The drug is taken orally after a meal, as it can cause diarrheal disorders. Tablets should be washed down with a glass of water. With prolonged use for the prevention of neuritis combined with the intake of B vitamins.

Instructions for use of Furazolidone

The dose for adults with paratyphoid, dysentery and food toxic infections is 0.1 g per day 4 times a day for 5-10 days. Single dose - 0.2 g, daily - 0.8 g.
With giardiasis - 0.1 g 4 times a day to 7 days, a week later, repeat the same course.
With trichomoniasis urethritis - 0.1 g 4 times for 3 days.
With trichomonas colpitis dosage and multiplicity of intake is the same and in parallel injected into the vagina powder containing Furazolidone and milk sugar, in the rectum - suppositories with a content of Furazolidone 4-5 mg.
To treat burns locally in the form of dressings with a solution of the drug (1: 25000).

Instructions for use for children

For children, the dose is calculated per kg of body weight. It is: single - 0.0025 g per kg, and daily 0.01 g per kg, distributed for 3-4 doses. The course of treatment is 5-7 days.

Application in veterinary medicine

Veterinary preparation is a yellow powder, insoluble in water.
The drug is used for salmonellosis, coccidiosis, colibacillosis, enteritis, balantidiosis in animals and birds. You can use a drug in the form of tablets (one 50 mg tablet).
Dosage for these diseases is the same for chickens, for turkeys and for broilers - the drug is added to the feed at the rate of 3 mg per head 2 times a day, the treatment is carried out for 8 days. If necessary, the course of treatment is repeated, but after a break of 10 days. Prophylactically, young animals up to 10 days of age are given daily 2 mg per head once a day.
Overdosing is unacceptable, since the bird has drowsiness, inhibition and death may occur. How to give chickens? It is better with food. Another option is vital-dissolve in water and give in the form of a drink. But you need to know that the drug is poorly soluble and loses its properties when exposed to sunlight.

Overdose

It is manifested by toxic hepatitis, polyneuritis and changes in the blood.
Treatment consists in the cancellation of the drug, the appointment of antihistamines and B vitamins, abundant drinking.

Interaction

Aminoglycosides and tetracycline increase its antimicrobial effect.
Antidepressants, phenylephrine, ephedrine, MAO inhibitors, tyramine, amphetamine in combination with furadonin cause a significant increase in blood pressure.
The drugs that alkalinize urine reduce the effect of the drug.
Oppression of hematopoiesis is intensified when used with Chloramphenicol and Ristomycin.
Incompatible with alcohol, since this combination causes disulfiram-like reactions.

Terms of sale

Without prescription.

Storage conditions

At a temperature not exceeding 25 ° C.
Shelf life - 3 years.

Furazolidone for children

Instruction for children provides the following indications for use: amoebic dysentery, salmonellosis, giardiasis.

How to give Furazolidone to children?

For children, the form of granules is convenient, from which a suspension is prepared by adding 100 ml of water. If properly prepared, 1 ml of the suspension will contain 0.0003 g of the preparation. The suspension is applied 4 times a day, measuring with a measuring cup and applied until the age of 7 years. Single dose is: in 1 -2 years for 4-5 ml, 3-4 years for 6-7 ml, 4-5 years for 7.5-8.5 ml.
From the age of 7, children can already take pills. The dosage of tablets for children is correspondingly lower than for adults. At the age of 7-14 years, a single dose of 0.03-0.05 g is recommended, daily - 0.12 g-0.15 g.
Parents' reviews testify to its effectiveness in intestinal infections.
"We took bifiform and enterofuril - nothing helped. The week was diarrhea until the doctor appointed Furazolidone + linex. "
"Smecta did not help, enterofuril too, eventually helped Furazolidone."
Usually, no adverse reactions were noted during the 5-day period of admission.

Furazolidone in pregnancy

The drug belongs to category C. This means that the study of the drug on animals has an adverse effect on the fetus, but there is no information on the effect on the fetus. According to the instructions, the drug is contraindicated in pregnancy. Can be appointed only for vital necessity, taking into account the expected and risk to the fetus.

Furazolidone for cystitis

How effective is this drug with cystitis? If we start from pharmacokinetics, then its greatest concentration is determined in the lumen of the intestine, and hence it follows that the drug will be most effective in intestinal infections. Of the group of nitrofurans in the treatment of urinary tract infections, it is better to use Furadonin, but it is more toxic.
If from cystitis Furazolidone can be used as monotherapy, then under pyelitis and pyelonephritis it is prescribed in combination with antibiotics. The derivatives of the nitrofuran series do not create therapeutic concentrations in the kidney parenchyma, therefore they are used only with cystitis.
Furazolidone tablets from cystitis in usual dosages, which were mentioned above, are used in uncomplicated course of the disease. With hemorrhagic or purulent cystitis, more serious treatment is required.

Furazolidone for diarrhea

Is this drug always shown? And is it possible to take it immediately with any disorder of the stool? There are clear indications - shigellosis, amoebic dysentery, salmonellosis. The drugs of choice for the treatment of salmonellosis and shigellosis are fluoroquinolone series preparations and Furazolidone. Sometimes even with acute intestinal infection (OCI) of mild and moderate form, especially in children, treatment is started with probiotics (Bifiform, Probiophore, Enterol, Bifystim) and enterosorbents (Filtrum, Neosmectin, Enterosgel). Only with severe forms or lack of effect from the previous treatment, 2-3 days are prescribed tablets against diarrhea Furazolidone.
Only a doctor can prescribe how to take with diarrhea, and in the absence of positive dynamics, a transition to antibiotics of the "reserve" (Imipenem, Azithromycin, Amikacin, etc.) is possible. Do not forget to take a course of probiotics after treatment.

Furazolidone analogues

Analogues on the active substance are absent Similar action have nirofuran derivatives Enterofuryl, Azithromycin.

Reviews of Furazolidone

Often asked about this drug - is it an antibiotic or not? It is not an antibiotic, but a synthetic antibacterial agent that differs from true antibiotics by the mechanism of action on microorganisms and exposure to the human body.
What makes Furazolidone tablets? Whether only at a diarrhea designate this preparation? Intestinal infections are the main indication for the use of the drug. In addition to Furazolidone, other intestinal antiseptics (Nifuroxazide, Rifaximin) may be prescribed to correct the microflora, followed by the use of probiotics.
Tablets Furazolidone in combination with sorbents and Creon is prescribed for the treatment of Giardiasis. This is very often encountered reviews. In this case, reviews about Furazolidone are mostly negative, since even a 10-day course did not lead to eradication of the parasite. More effective metronidazole or makmiror than furozolidone. What helps with this drug? With infections of the urinary system, it is prescribed for 7-14 days.
There are other indications for the use of Furazolidone, of which the abstract does not indicate. For example, antihelikobakternaya therapy, including Furazolidone, is effective in the treatment of erosive and ulcerative diseases in adults. The same scheme applies treatment for children infected with chylobacter pylori (HP). It includes De-nol, Furazolidone, Amoxicillin, Ranitidine and after treatment is achieved 100% eradication of HP.
In the reviews often indicated on the side effects of the drug - nausea and sometimes vomiting. Taking the drug without a doctor's appointment, carefully study all contraindications and observe the recommended dose.

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