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Itomed tabs 50mg #40

  • $26.38
  • 3 or more $25.99
  • Availability:In Stock

Itomed instruction for useReed more and buy Itomed on this pageCompositionIttopride hydrochloride 50 mg.Lactose monohydrate, magnesium stearate, corn starch, croscarmellose sodium, silicon dioxide as auxiliary substances.Form of i..

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Itomed instruction for use

Reed more and buy Itomed on this page


Ittopride hydrochloride 50 mg.
Lactose monohydrate, magnesium stearate, corn starch, croscarmellose sodium, silicon dioxide as auxiliary substances.

Form of issue

Tablets in a film shell.

pharmachologic effect

Antiemetic, stimulating the motility of the gastrointestinal tract.

Pharmacodynamics and pharmacokinetics


Prokinetics, which has an effect on the motor function of the gastrointestinal tract. Prevents the anti-peristaltic contractions of the musculature. Has a combined mechanism of action, which consists in interacting with D2-dopamine receptors and blocking acetylcholinesterase. Prevents the destruction of acetylcholine and activates its release. This causes an increase in gastrointestinal motility throughout the digestive canal: accelerates the passage of food through the stomach and intestines, improves their emptying.
The antiemetic effect is related to the interaction of tautopride with D2 receptors, which are located in the trigger zone (the bottom of the fourth ventricle of the brain). Suppresses vomiting, which is caused by apomorphine and this effect is dose-dependent.
The advantage is the low ability to penetrate the BBB, therefore there are no extrapyramidal and neuroendocrine effects. Does not change the concentration of the hormone gastrin in the serum.


Quickly absorbed in the digestive tract. Bioavailability of 60%. Food does not affect the bioavailability of the drug. The maximum concentration is 0.5 hours. With repeated administration for 7 days, cumulation is minimal.
96% bound to proteins. It is well distributed in tissues and is found in high concentrations in the small intestine, stomach, kidneys, liver and adrenal glands. Slightly penetrates the brain.
Metabolized in the liver to 3 metabolites, one shows little activity. Itopride has no effect on CYP2C19 and CYP2E1. The elimination half-life is 6 hours. It is excreted by the kidneys.

Indications for use

    chronic gastritis with dyspepsia;
    discomfort in the epigastric region;
    pain in the stomach;
    nausea and vomiting;

Contraindications for Itomed

    mechanical perforation of the gastrointestinal tract;
    bleeding from the gastrointestinal tract;
    deficiency of lactase;
    impaired absorption of glucose-galactose;
    hypersensitivity to the drug;
    age to 16 years.
Itomed with caution should be given to patients with severe impairment of liver and kidney function.

Side effects

    urticaria, anaphylactic shock;
    headache, irritability, insomnia, tremor;
    leukopenia, thrombocytopenia;
    gynecomastia, hyperprolactinemia;
    excessive salivation, nausea, epigastric pain, jaundice, diarrhea, or constipation;
    increased activity of transaminases, hyperbilirubinemia.

Itomed, instructions for use (Method and dosage)

The drug is taken orally, before meals. The dose for adults is 50 mg 3 times. The daily dose of 150 mg. For the elderly, the dose decreases.
Instructions for use Itomed contains a warning about if the time of taking the drug is missed. In this case, do not take a double dose and continue to take as usual.


Is manifested by increased adverse reactions. The stomach is washed and symptomatic treatment is prescribed.


Itomed accelerates absorption of other drugs, as it increases gastric motility. This fact should be taken into account in the appointment of drugs that have a delayed release of the active substance or low bioavailability.
The cholinergic effect of the drug is enhanced by the joint administration of m-cholinomimetics and cholinesterase inhibitors.
M-holinoblokatory (Gastril, Gastrozem, Gastrotsepin, Hyoscine) reduce the effectiveness of tared. Means that reduce the acidity of gastric juice, do not affect its activity.
Anti-ulcer drugs (cimetidine, ranitidine, cetracsat) do not affect the prokinetic effect of taredropide.
When co-administered with Warfarin, Diazepam, Nifedipine, Diclofenac, Ticlopidine, binding to proteins does not change.

Terms of sale

You can buy Itomed without a prescription.

Storage conditions

At temperatures up to 25 ° C.
Shelf life - 3 years.

Reviews of Itomed

Despite the fact that this drug in the arsenal of doctors for about 15 years, reviews about Itomed on forums are rare. Nevertheless, there are reviews about its use in chronic reflux esophagitis and GERD. Against the background of treatment, there was a decrease in heartburn, bloating and a feeling of heaviness in the stomach, and appetite improved. The treatment was carried out for 6-8 weeks. There are reviews about the effective treatment of these drugs with chronic constipation.
In general, the drug is well tolerated and there were no serious side effects. The most common were diarrhea, abdominal pain, headache. There is one message that Itomed called amenorrhea.

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