Losec Mups 20mg #28

Losec Mups instruction

You can buy Losec Mups on this page

Composition

In addition to omeprazole, Losec Mups tablets contain MCC, hydroxypropyl cellulose, magnesium stearate, granulated sugar, polyethylene glycol, polyvinylpyrrolidone crosslinked, talc, iron oxide, glyceryl monostearate, hydroxypropylmethylcellulose, methacrylic acid copolymer, paraffin, polysorbate, sodium stearyl fumarate, triethyl citrate, titanium dioxide.

Form of issue

The medicine is sold in the form of tablets, which are covered with a shell.

pharmachologic effect

The drug reduces the secretion of stomach acid. This is a special inhibitor of the proton pump.

Pharmacodynamics and pharmacokinetics

The medicine is an antiulcer. It inhibits the effect of H + -K + -ATPase in gastric parietal cells. Thus, the last stage of formation of hydrochloric acid is blocked. The action of the drug depends on the dose. It effectively inhibits basal and stimulated secretions with daily use.
The drug reaches its maximum efficiency within 4 days. Its action in combination with antibacterial agents causes the eradication of Helicobacter pylori. Due to this, the manifestations of the disease are suppressed, a stable remission is achieved, lesions of the gastric mucosa are healed, and the risk of bleeding from the gastrointestinal tract is reduced. When using Losec mups, there is no need for long antiulcer therapy.
The tablets are absorbed into the small intestine. Absorption is completed in 3-6 hours after use. At repeated reception of the means bioavailability rises to 60%. Eating does not affect her. The connection with plasma proteins is about 95%.
The half-life of plasma is less than an hour. The active substance of the drug is completely cleaved by the cytochrome system, mainly in the liver. 80% of the drug is excreted in the form of metabolites with urine, and another 20% - with feces.

Indications for use

The medicine is prescribed for:
    acid-dependent dyspepsia;
    gastric ulcer caused by Helicobacter pylori;
    Zollinger-Ellison syndrome;
    stomach ulcer and duodenal ulcer (including, if the disease is caused by NSAIDs);
    gastroesophageal reflux.

Contraindications

Do not use this product for allergies to its components.

Side effects

As a rule, the medicine is well tolerated by patients. Undesirable adverse reactions are usually mild and quickly disappear. Among them are:
    skin - rashes, itching, photosensitivity, alopecia, erythema multiforme;
    CNS - drowsiness, headache, vertigo, dizziness, paresthesia, insomnia, confusion, depression, agitation, hallucinations;
    liver - violations of the liver, increased levels of liver enzymes, encephalopathy (with liver disease with complications), hepatitis;
    circulatory system - leukopenia, agranulocytosis, thrombocytopenia, pancytopenia;
    the musculoskeletal system - muscle weakness, painful sensations in the joints and muscles;
    Gastrointestinal tract - diarrhea, pain in the abdomen, vomiting, constipation, nausea, flatulence, dry mouth, candidiasis, stomatitis;
    endocrine system - gynecomastia;
    other - urticaria, fever, interstitial nephritis, angioedema, bronchospasm, anaphylactic shock, severe sweating, blurred vision, decreased sodium levels in the blood, peripheral swelling, a taste disorder, malaise.

Instructions for use Losec mups (Method and dosage)

Instruction for the use of tablets Losec mups (and not Losec Max, as many believe) reports that they are intended for oral use. Swallow whole, without chewing. It is advisable to drink with liquid. In addition, the tablets can be dissolved in fruit juice or water. Such a solution should be drunk within half an hour after preparation.
Instruction for use Losec mups informs that the exact scheme of use of the medicine depends on the disease:
    stomach ulcer and duodenal ulcer in the phase of exacerbation - the patient should take 20 mg of medication every day. The course is designed for 2 weeks. If complete scarring does not occur, you can repeat therapy for 2 more weeks;
    the need to prevent the exacerbation of duodenal ulcer - a patient should take 10 mg of medication every day. If necessary, increase the dosage to 20-40 mg;
    a stomach ulcer resistant to therapy - 40 mg of medication per day. Recovery is usually within eight weeks;
    erosive and ulcerative lesions in the gastrointestinal tract (gastroduodenal department) in HIV-infected patients - 20 mg are applied once a day. Compatible with HIV therapy. The average course is 4 weeks. If there is no complete cure, you can repeat the therapy;
    a stomach ulcer provoked by Helicobacter pylori - maybe three different treatment regimens. 1) 20 mg Losec mups, 500 mg Clarithromycin and 1 g Amoxicillin. 2) 20 mg Losec mups, 250 mg of Clarithromycin and 500 mg of Tinidazole (or 400 mg of Metronidazole). All medicines should be consumed during the week daily 2 times. 3) Throughout the week, take 20 mg of Losec mups once every day, 400 mg of Metronidazole 3 times, 500 mg of Amoxicillin 3 times. In addition, the doctor can prescribe a "double therapy". In this case, Losec mups is drunk daily in a dosage of 40-80 mg, and Amoxicillin - 1.5 g (the dose is divided into parts). The course is designed for two weeks. After eradication of Helicobacter pylori, subsequent therapy is carried out according to the usual scheme, as with duodenal ulcer and stomach. If, at the end of the course, the Helicobacter pylori test is positive, the treatment can be repeated;
    duodenal ulcer, resistant to therapy - 40 mg of medication daily. Healing occurs in most cases within a month;
    stomach ulcer in the phase of exacerbation - you need to take 20 mg of medication a day. The therapy is designed for 4 weeks. If the ulcer at the end of the course is not completely healed, the treatment can be repeated;
    the need to prevent exacerbations of stomach ulcers - should take 20 mg of medicine a day. If necessary, the daily dosage rises to 40 mg;
    the need to prevent exacerbations of gastric and duodenal ulcers, the appearance of dyspeptic symptoms in the stomach ulcer, as well as erosive lesions of the gastroduodenal department - experts appoint patients to take daily 20 mg of the drug;
    Esophageal reflux - 20 mg of medication per day. Therapy is calculated on average for a month. If the patient is not completely cured, the course can be repeated;
    esophageal reflux in remission - experts prescribe to take 10 mg of Losec mups per day, if necessary, the dose can be increased to 20-40 mg. Admission is designed for a long course of maintenance therapy;
    pain, discomfort and heartburn in the epigastric region associated with acid-dependent dyspepsia - begin with a daily dosage of 10 mg, which if necessary can be brought to 20 mg. The therapy is designed for 4 weeks. If the symptoms do not disappear after completing the course, it is advisable to change the treatment regimen;
    severe form of esophageal reflux - 40 mg of medication per day. Therapy is usually designed for 2 months;
    symptomatic gastroesophageal reflux - dosages are established in each case individually. Usually take 10-20 mg daily. The therapy is designed for 4 weeks. If the symptoms do not disappear at the end, it is advisable to change the treatment schedule for Losec mupsom;
    Zollinger-Ellison syndrome - dosages in each case are individual. The recommended dose for starting therapy is 60 mg every day. If the daily dosage is more than 80 mg, it must be divided into 2 divided doses.
If the patient has problems with liver function, the bioavailability and clearance of the active substance Losec mups increase, so that the daily dosage usually should not be more than 20 mg.

Overdose

Single dose of the drug to 400 mg taken orally, did not cause severe symptoms. The rate of excretion of the drug at elevated dosages does not increase. Specific therapy is not required.

Interaction

The combination of Losec mups and Ketoconazole may lead to a decrease in the degree of absorption of the latter.
In addition, the drug may increase the time to eliminate Warfarin, Phenytoin and Diazepam. Therefore, dosage adjustment may be required. But the daily use of 20 mg Losec mups does not affect the level of Phenytoin in blood plasma for prolonged therapy, nor does it change the coagulation time with long-term use of Warfarin.
The combined use of omeprazole and Clarithromycin causes an increase in their plasma concentrations.

Storage conditions

Store the medicine at a temperature of up to 25 ° C. The lid of the vial should be well closed after applying the drug. Keep out of the reach of children.

Shelf life

Three years from the date of manufacture. Do not use drugs after the expiration date.

Losec Mups Analogs

The most common analogs of Losec Mups:
    Omeprazole;
Each of these medicines has its own nuances of application, so they should not be taken alone, without prescribing a doctor.

Reviews of Losec Mups

Reviews about Losec mups as a preparation for the treatment of peptic ulcer diseases are extremely positive. Patients noted the rapid action and effectiveness of the drug. Symptoms such as heartburn disappear at the beginning of therapy.
Among the minuses, reviews about Losec mups only report a relatively high price and uncomfortable size of tablets. In addition, some patients write about side effects, for example, about nausea at the beginning of the course.