Ultop caps 20mg #28

Instruction for Ultop

Reed more and buy Ultop capsules on this page

Composition

1 capsule contains omeprazole 10, 20 or 40 mg.

Form of issue

Capsules gelatinous 10 mg, 20 mg, 40 mg

pharmachologic effect

Oppression of acid formation, has a cytoprotective effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Irreversibly binds to the enzyme H + / K + -ATPase, known as a proton pump. Oppresses its activity, which leads to a decrease in basal and stimulated secretion. The effect of the drug depends on the dose. The effect is manifested after 1 hour, and maximum - after 2 hours and lasts 24 hours. At the end of the treatment, the secretion is normalized within a week. At reception of 20 mg acidity decreases on 90% and on 94% at reception of 40 mg.

Pharmacokinetics

Suction occurs in the small intestine for 3-6 hours. Cmax in the blood after 0.5-1 h. Biological availability is 35%. Bioavailability increases in the elderly and in case of impaired liver function. Metabolised in the liver. It is excreted by the kidneys (70%) and with bile (30%).

Indications for Ultop

    gastroesophageal reflux;
    erosive gastritis and duodenitis, caused by the administration of NSAIDs;
    peptic ulcer;
    eradication of Helicobacter pylori (in complex therapy);
    Stress and peptic ulcers;
    Zollinger-Ellison syndrome.

Indications for use of capsules 10 mg:

    symptoms of dyspepsia (eg, heartburn);
    short-term therapy;
    anti-relapse treatment;
    prophylaxis of ulcers and erosions when taking NSAIDs.

Contraindications

    pregnancy and lactation;
    individual intolerance to omeprazole;
    age up to 12 years;
    hereditary intolerance to fructose;
    simultaneous reception with atazanavir;
    severe kidney and liver disease;
    the patient has glucose-galactose malabsorption.

Side effects

    diarrhea or constipation, flatulence, dry mouth, vomiting, stomatitis, transient increase in liver enzymes;
    insomnia, headache, agitation, dizziness, depression, hallucinations, encephalopathy (with severe liver disease);
    tachycardia, stenocardia, increased blood pressure, peripheral edema;
    interstitial nephritis, the appearance of protein, erythrocytes and sugar in the urine, an increase in creatinine in the blood;
    in men - an increase in mammary glands and pain in the testicles;
    cramps, arthralgia, bone pain, myalgia;
    agranulocytosis, thrombocytopenia, anemia, leukopenia, neutropenia;
    dry skin, itching, rashes, alopecia;
    cough, nosebleeds;
    visual impairment, ringing in the ears;
    fatigue, weakness, weight gain.

Ultop, instructions for use (Method and dosage)

Capsules are taken orally, without chewing, before eating with a small amount of liquid. Duration of admission is determined by the doctor.
With exacerbation of peptic ulcer of the duodenum - 20 mg / day.
With GERD - 20 mg, with a severe course of GERD 40 mg before breakfast with the transition to maintenance treatment.
With gastric ulcer and esophagitis - 20-40 mg / day.
Erosion on the background of NSAIDs - 20 mg / day.
Eradication Helicobacter pylori - 20 mg 2 r / day. in combination with antibacterial agents. For prophylaxis - 10 mg / day.
Zollinger-Ellison syndrome - start taking with 60 mg / day. An increase of up to 120 mg / day is possible.
Instructions for use Ultop should be observed to avoid overdose and side effects.

Overdose

It is established that patients tolerate a dose of up to 360 mg.
When an overdose appears nausea, drowsiness, dizziness, tachycardia, blurred vision, increased sweating, agitation, in rare cases - convulsions.
Treatment is symptomatic.

Interaction

Can reduce the absorption of ampicillin, ketoconazole, iron salts. Increases the concentration of diazepam, neodicumarin, sinkumara, phenylin, which requires a reduction in the doses of these drugs. When taking with clarithromycin, the concentrations in the blood of both drugs increase.

Terms of sale

To buy Ultop online you don't need a prescription.

Storage conditions

At temperatures up to 25 ° C.
Shelf life - 3 years.

special instructions

Ultop is recommended to be taken before meals, as eating slightly slows down absorption. If there are difficulties with swallowing the capsule, its contents can be mixed with the juice and drink the suspension.
In children who take the drug for a long time, the level of vitamin B12 may decrease.
In view of the content of sucrose, Ultop is not recommended for patients with the syndrome of glucose-galactose malabsorption.
In normal dosages, the drug does not affect the rate of reactions when driving vehicles, but remember that dizziness, visual disturbances and drowsiness are possible.

Reviews about Ultop

Ultop: reviews of doctors

According to reviews of practicing doctors, when treating acid-dependent diseases, it is better to take quality generics, which include Ultop. Among the omeprazoles presented in Russia, only this drug has bioequivalence with the original omeprazole, which is proved in the laboratories of Germany.
In clinical trials in the gastroenterology department of MONIKI them. M.F. Vladimir Ultop showed high efficiency in combination with clarithromycin and amoxicillin during anti-Helicobacter therapy. Its clinical effectiveness is manifested in the rapid relief of symptoms (primarily heartburn) and the healing of erosive and ulcerative defects. After treatment, there is a long-term remission.
Patients' feedback suggests that Ultop is a combination of efficacy, good tolerability with a moderate price.