Nolpaza tabs 40mg #28

Nolpaza instruction

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Composition

The composition of one tablet of Nolpaza 20 includes 20 mg of pantoprazole sodium (recalculated for pantoprazole), as well as sorbitol, mannitol, crospovidone, calcium stearate, sodium carbonate anhydrous as adjuvants.
The composition of one pill Nolpaza 40 includes 40 mg of Pantoprazole sodium (recalculation on pantoprazole), and similar auxiliary substances.

Form of issue

Produced in the form of oval, slightly biconcave tablets, which covers a light brown-yellow film membrane. At the break, the tablet is rough, has a color from white to light yellow. It is produced in contour acheikova packing of 14 pieces, is realized in cardboard boxes for 1, 2 or 4 packs in each.

pharmachologic effect

Nolpaza is a hypoacid preparation that is part of the proton pump inhibitor group. In its composition there is an active substance - pantoprazole, which is a derivative of benzimidazole. This substance inhibits the activity of H + / K + ATPase. Getting into an acidic environment, the active component of Nolpaza becomes a pharmacologically active form and provides a blockage of the last stage of hydrophilic secretion of HCl in the stomach. Basal and stimulated production of hydrochloric acid is inhibited by the drug equally actively. The use of the drug leads to an increase in the secretion of gastrin, however, this phenomenon is reversible.

Pharmacodynamics and pharmacokinetics

The drug is applied orally, after which its active component is rapidly absorbed into the bloodstream. Bioavailability of the active substance is 77%, it does not depend on food intake. The greatest concentration in the plasma is observed in 2-2.5 hours after ingestion of Nolpaza.
A characteristic feature of the drug is a high level of communication with blood proteins - about 98%. The drug is metabolized in the liver, its elimination occurs in the form of metabolites in the urine, a small part - with feces. The half-life of pantoprazole is 1 hour, its metabolite is excreted after 1.5 hours.
Patients suffering from impaired liver function, it is necessary to adjust the dose of the drug. Elderly patients, as well as patients suffering from kidney disorders, the dose is not adjusted.

Indications for use

Before starting treatment, you need to know clearly from what tablets are used. Indications for use Nolpaza are as follows:
    gastroesophageal reflux disease of mild degree;
    reflux-esophagitis of various degrees (treatment and prevention);
    peptic ulcer of the stomach and duodenum;
    states that provoke hypersecretion (Zollinger-Ellison syndrome, etc.);
    eradication of Helicobacter pylori (prescribed in combination with antibiotics).
In addition, indications for the use of medication are, if a preventive remedy is needed to protect against the development of ulcerative lesions of people undergoing long-term treatment with nonsteroidal anti-inflammatory drugs.

Contraindications

Contraindications for taking Nolpaza are as follows:
    High sensitivity to the components of the drug (intolerance to fructose, etc.).
    Nolpaza 40 mg is not used together with antimicrobial agents to treat patients with severe kidney and / or liver disease.
    Do not take the drug to people with neurotic dyspepsia.
The drug is administered with caution:
    People suffering from liver disease. If treatment is carried out for a long time, it is necessary to monitor the level of hepatic enzymes in patients.
    Those who have a high risk of ulcers, intestinal, gastric bleeding.
    Patients with a high risk of developing hypovitaminosis B12.

Side effects

Before you buy Nolpaza at our online store, you should know side effects of the drug.
As a rule, taking the drug does not provoke the appearance of undesirable effects. However, sometimes the following side effects occur:
    In the functions of the gastrointestinal tract: disturbance of the stool, gastralgia, flatulence, nausea, increased level of hepatic enzymes. Rarely there is hepatotoxic effect, jaundice, sometimes jaundice, which is accompanied by hepatic insufficiency.
    In the functions of the central nervous system: dizziness, headache, emotional lability, visual impairment.
    In the functions of the urinary system: the appearance of edema, interstitial nephritis.
    Perhaps the manifestation of allergic reactions: itching, rashes on the skin, hives, photosensitivity. Quincke's edema is rarely developed.
    In some cases, muscle pain is noted, body temperature rises, hypertriglyceridemia is noted.

Instructions for use (Method and dosage)

The drug is administered orally. Instructions for Nolpaza 40 mg and 20 mg are as follows: you need to swallow the whole medicine without chewing, drink plenty of liquid. The drug is optimal before meals. If the doctor has prescribed Nolpaza 1 tablet per day, then it is better to take it in the morning. Detailed instructions for use Nolpaza, as well as dosage is determined by the doctor individually.
People with mild form of gastroesophageal reflux disease, as a rule, are prescribed Nolpaza 20 mg, not more than one tablet per day. Treatment lasts from 14 days to 1 month, sometimes the doctor decides to extend the therapy for 2 months.
In the treatment of exacerbation of reflux esophagitis, as well as for prevention purposes, 20 mg of the drug are prescribed once a day. If there is a high probability of recurrence of the disease, the dose is increased to 40 mg once a day. When the condition improves, the dose is again reduced to 20 mg. Adults who receive non-steroidal anti-inflammatory drugs take Nolpaza to prevent ulcerative lesions (20 mg once a day).
In Helicobacter pylori eradication schemes, Nolpaza is administered 40 mg twice a day, while taking the drug should be combined with taking antimicrobials. You need to take the pill in the morning and in the evening.
Those patients who suffer from Zollinger-Ellison syndrome and other diseases that are accompanied by increased secretion are prescribed initially 40 mg twice a day, if necessary, the dose can be increased to 80 mg daily.
If a person has irregularities in the work of the liver, then daily it can take no more than 20 mg of pantoprazole. Before starting treatment with the drug, it is necessary to undergo studies and exclude the presence of a malignant tumor in the esophagus and in the stomach.

Overdose

There was no information on overdose. The drug is well tolerated, even in large doses. If a person feels bad, it is necessary to wash the stomach, take enterosorbents, conduct symptomatic treatment.

Interaction

If you combine the drug and ketoconazole and other drugs with pH-dependent absorption, the bioavailability of the latter is reduced.
If Nolpaza is taken with coumarinic anticoagulants, then the effectiveness of the latter can vary.
With the combination of Nolpaza with antacids, the pharmacokinetics of these drugs do not change.

Storage conditions

Store the medicine in a dry place, protect from light. The storage temperature should be between 15 and 30 degrees.
Shelf life - 2 years.

special instructions

Before the beginning of treatment it is necessary to exclude from the patient the presence of an oncologic neoplasm, since in the course of treatment symptoms can be masked, in connection with which the diagnosis will not be made in time. If a month later the patient does not have the results of treatment with the drug, he needs to undergo another examination. In case of prolonged treatment, obligatory regular supervision with a doctor is necessary. The speed of the reaction, working with mechanisms and management of vehicles Nolpaza does not affect.

Omez or Nolpaza - which is better?

Omez is an antiulcer agent of the proton pump inhibitor group with the active substance omeprazole. The drug, like Nolpaza, effectively reduces the level of hydrochloric acid. As evidenced by patients' reviews, Nolpasa acts more quickly and efficiently.

Which is better: omeprazole or Nolpaza?

Omeprazole also belongs to the group of proton pump inhibitors and suppresses the secretion of hydrochloric acid. The effect of the drug is also effective, but omeprazole and Nolpaza should not be used interchangeably without the doctor's approval.

Nolpaza or Ultop - which is better?

The active substance of the drug Ultop is also omeprazole. There are a number of contraindications for its administration, in particular, the drug is not used to treat children under 12 years old. Determine which drug is more effective - Nolpaza or Ultop, can only a doctor, while taking into account the individual characteristics of the patient's health status.

Children

Nolpaza is not used to treat children and adolescents under the age of 18, as there is still no data on the safety of this therapy and its effectiveness.

With alcohol

Clinical trials showed no significant effect of the drug with ethyl alcohol. Nevertheless, Nolpaza and alcohol are incompatible, since alcohol can not be used in diseases that are treated with this drug.

In pregnancy and lactation

Now there is no sufficient experience of using Nolpaza during pregnancy and feeding. The remedy for a pregnant woman can be prescribed by the attending physician, before clearly assessing the benefits to the woman and the risk to the fetus. Treatment with Nolpaza during pregnancy is carried out in minimum doses and for a short period of time. There is no data on the ingestion of the active substance into milk. Before treatment during lactation, consult a doctor. It may be necessary to interrupt feeding.

Reviews on Nolpaza

Both the doctors' reviews of Nolpaza tablets and the responses on the forums are mostly positive. Patients note that the positive effect of treatment, as a rule, appears after a long reception of funds.
In particular, there is a positive effect in the treatment of gastric ulcers, with pain in the stomach during gastritis. According to the patients, the drug effectively removes the feeling of heaviness in the stomach. There are no marked side effects.