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Omez D caps

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  • $18.78
  • 3 or more $16.90
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Omez D capsules user manualYou can buy Omez D on this pageCompositionThe composition of Omez D includes two active substances: domperidone and omeprazole (in the form of pellets, which covers the shell, soluble in the intestine). ..

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Omez D capsules user manual

You can buy Omez D on this page

Composition

The composition of Omez D includes two active substances: domperidone and omeprazole (in the form of pellets, which covers the shell, soluble in the intestine). Auxiliary ingredients are magnesium stearate, MCC, carboxymethyl starch sodium, silicon colloidal dioxide, sodium lauryl sulfate, talc.

Form of issue

Produced in the form of hard capsules made of gelatin. Capsules have a white body and a lid of light purple. On the capsule there is an inscription "Omez D" and the logo "DR.REDDY'S". Inside the capsule is an off-white powder.
Capsules are placed in strips of 10 pieces, which fit into cardboard packs.

pharmachologic effect

The Omez D combination drug contains omeprazole and domperidone, which is a blocker of central action of dopamine receptors.
Under the influence of domperidone, the peristalsis of the duodenum and antrum of the stomach increases. When the process of gastric emptying slows down, the action of this substance makes it possible to activate the process. Domperidone stimulates the tone of the lower esophageal sphincter, prevents vomiting and nausea. Also, the substance stimulates prolactin production by the pituitary gland.
Omeprazole blocks the last stage of hydrochloric acid secretion. As a consequence, basal and stimulated secretion is reduced.
In combination, omeprazole reduces the secretion of hydrochloric acid, and domperidone increases the tone of the esophageal sphincter and activates the emptying of the stomach. As a consequence, the aggressiveness of gastric juice decreases and the contents of the stomach are thrown into the esophagus.

Pharmacodynamics and pharmacokinetics

Domperidone through the BBB penetrates poorly, therefore when using domperidone extrapyramidal side effects develop rarely. The substance is absorbed quickly after ingestion. Bioavailability is approximately 15%. The greatest concentration in the plasma - after 1 hour. It is distributed in all tissues, with plasma proteins binds about 90%. Metabolism occurs in the liver and in the wall of the intestine. It is excreted through the intestine and kidneys.
Omeprazole after oral administration begins to act after 1 hour, after 2 hours the maximum effect is achieved. The exposure lasts 24 hours. There is a rapid adsorption of the substance from the gastrointestinal tract, the greatest concentration in the plasma - after about 1 hour. Bioavailability is 30-40%. With plasma proteins, the bond is approximately 90%. Almost completely omeprazole is metabolized in the liver. The main part is excreted through the kidneys, another 30% - with bile.

Indications for use Omez D

Indications for the use of the drug - therapy of dyspepsia and gastroesophageal reflux, if monotherapy with proton pump inhibitors or other drugs is ineffective.

Contraindications

Contraindications to the treatment of Omez D are such conditions and diseases:
    hypersensitivity;
    gastric or intestinal bleeding;
    perforation of the stomach or intestines;
    obstruction of the gastrointestinal tract of a mechanical nature;
    prolactinoma;
    lactation;
    childhood.
Caution means used for hepatic and renal failure, during pregnancy.

Side effects of Omez D

When taking domperidone, the following side effects may occur:
    transient intestinal spasms;
    urticaria, rash on the skin;
    extrapyramidal disorders;
    hyperprolactinemia.
When taking omeprazole, sometimes there are such side effects:
    Functions of the gastrointestinal tract: dyspepsia, taste disorders, a feeling of dry mouth, stomatitis, an increase in the activity of liver enzymes in the plasma.
    Nervous system: drowsiness, dizziness, insomnia, headache, depression, the manifestation of hallucinations.
    Musculoskeletal: myalgia, muscle weakness, arthralgia.
    Hemopoiesis: thrombocytopenia, leukopenia.
    Skin: rash on the skin, itching.
    Allergic manifestations: edema, urticaria, bronchospasm, fever.
    Vision may also be impaired, sweating may be marked, in the course of prolonged therapy, in rare cases gastric glandular cysts may form.

Instructions for use Omez D (Method and dosage)

If the patient is assigned Omez D, the instruction for use provides that the capsule should be taken 1 piece each. twice a day. It is advisable to take the drug about 20 minutes before eating. Capsules at reception should be washed down with a small amount of liquid.

Overdose

With an overdose of domperidone, the patient may develop disorientation, attacks of drowsiness, extrapyramidal reactions. In this case, you need to take activated charcoal. If the patient develops extrapyramidal reactions, it is necessary to take anticholinergic, antihistamine, anti-Parkinsonian drugs.
If an overdose of omeprazole occurred, the patient may have a disturbance of consciousness, visual impairment, nausea, headaches, arrhythmia. In this case, symptomatic therapy is used.

Interaction

Anticholinergic drugs neutralize the effect of domperidone.
With simultaneous treatment of sodium bicarbonate, cimetidine, as well as other antacid and antisecretory drugs reduce the level of bioavailability of domperidone.
Antibiotics (a group of macrolides), antifungal drugs related to the azole series, nefazodone, HIV protease inhibitors increase the level of domperidone concentration in the blood plasma.
Omeprazole can reduce the absorption of esters, iron salts, itraconazole and ketoconazole, ampicillin. Also this substance can reduce the excretion of anticoagulants of indirect effects, phenytoin, diazepam. Sometimes it is necessary to reduce the doses of these drugs.
Omeprazole increases the effect of other drugs on the hematopoiesis system.

Storage conditions

Keep the product in a dark and dry place, at a temperature of no more than 25 ° C. The drug should be protected from children.
Shelf life of the capsules is 2 years.

special instructions

Before the beginning of therapy it is necessary to conduct a survey and exclude all malignant diseases of the digestive system, since in the treatment of the remedy the symptoms may be masked.
Care should be taken to drive vehicles and work with dangerous devices during the treatment period.

Children

Children do not get treatment with the drug, as there is no precise information about its safety.

In pregnancy and lactation

Pregnant women Omez D is prescribed only if the benefit of such therapy exceeds the level of risk to the fetus. Breastfeeding during drug treatment should be discontinued.

Reviews about Omez D

Reviews of doctors and patients about this drug are mostly positive. It is noted that Omese D, in addition to improving the condition of the patient with peptic ulcer and other diseases of the gastrointestinal tract, effectively relieves patients from constipation. Side effects are very rare.

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