Omez DSR cap 30mg + 20mg #30

Omez DSR user manual

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Composition

The structure of Omez DSR includes the active substances omeprazole and domperidone, both substances - in the form of pellets. As additional ingredients, the preparation contains lactose, mannitol, anhydrous sodium hydrophosphate, sodium lauryl sulfate, hypromellose, sucrose, sodium hydroxide, methacrylic acid copolymer (type C), purified water, titanium dioxide, macrogol, purified talc, ethyl cellulose, sugar nonparel, silicon colloidal dioxide, iron oxide red, iron oxide yellow, triacetin.

Form of issue

Omega DSR is available in the form of gelatinous transparent capsules, on which there is a black logo and the inscription "Dr. Reddy's ». On the shell of the capsule is a red inscription "Omez-Dsr". Inside the capsules contain spherical pellets, which can have a shade from white to yellowish-gray. Blisters are packed in 10 capsules, blisters are put in a cardboard box.

pharmachologic effect

This is a combined medicine that helps inhibit the secretion of hydrochloric acid and regulates the motor function of the gastrointestinal tract.
Omeprazole is a proton pump inhibitor, an antisecretory drug. The substance is activated in an acidic medium. Under its influence, the last stage of transport of hydrogen ions is blocked. As a consequence, acid secretion is inhibited.
Domperidone is an antagonist of peripheral dopamine receptors. Under its influence, the smooth muscles of the stomach and small intestine are regulated. Due to the influence of domperidone, the duration and frequency of muscular contractions increases, and the contents of the stomach pass more intensively through the stomach and small intestine. Also, the substance helps increase the pressure of the sphincter of the lower part of the esophagus. Domperidone has an antiemetic effect.
In combination, domperidone and omeprazole have a beneficial effect on the motility of the stomach and intestines, as well as the acidity of the gastric juice.

Pharmacodynamics and pharmacokinetics

Domperidone is absorbed 93% by getting into the digestive tract, the absorption is very fast. At the same time, bioavailability when taken orally is 13-17%.
The highest concentration of the substance in the blood is observed 90 minutes after oral administration and does not change during the entire period of the drug intake. With blood proteins, domperidone binds up to 90%. Metabolised in the liver. It is excreted through the kidneys and intestines. The half-life is 7-9 hours.
Omeprazole is absorbed very quickly after oral administration. Its bioavailability is 65%. The greatest concentration of substance in the body is observed after 1 hour. With plasma proteins, the substance binds to 95%. Metabolised in the liver. The bulk of metabolites is excreted in the urine, another 18% - with feces.

Indications for use

Omega DSR is used to treat and alleviate the symptoms of gastroesophageal reflux disease.

Contraindications

The drug is not treated with such diseases and conditions:
    an increased level of prolactin in the body (prolactinoma);
    intestinal obstruction;
    bleeding in the stomach or intestines;
    any conditions in which activation of motility of the gastrointestinal tract can worsen the state of health;
    pregnancy, breast-feeding;
    childhood;
    hypersensitivity to the active substances of the drug.

Side effects

Omez DSR can provoke the development of the following adverse reactions:
    itching, urticaria, other allergic manifestations;
    galactorrhea in women;
    gynecomastia and deterioration of potency in men;
    dry mouth;
    symptoms of gastrointestinal dysfunction;
    dizziness, insomnia, paresthesia, agitation, depressive condition;
    myalgia, arthralgia, vision impairment, edema;
    fever, malaise;
    bronchospasm;
    encephalopathy, liver failure in people who had previously suffered from liver disease.

Instructions for use Omez DSR (Method and dosage)

If the patient has been prescribed Omez DSR, the instructions for use should be clearly observed. The drug should be taken orally, in the morning one hour before a meal. It is usually prescribed 1-2 capsules. At the same time, they must be swallowed whole without chewing. The instruction indicates that the greatest dose of the drug per day should not be above 80 mg (calculation for domperidone).
Elderly patients may not reduce the dose during treatment. Caution should be prescribed to people with liver disease, as the metabolism of active substances occurs precisely in the liver. Also cautiously assigned to patients with severe kidney disease.
The course of taking the medication can last for 4 weeks.

Overdose

With an overdose of domperidone, drowsiness, disorientation, drowsiness, disorientation, extrapyramidal disorders may also occur. When these signs manifest themselves, symptomatic treatment is performed. If extrapyramidal disorders are noted, the use of anticholinergics is indicated, which is used in the therapy of Parkinson's disease.

Interaction

Omeprazole, when taken concomitantly, increases plasma concentrations of phenytoin, diazepam, and anticoagulants.
Omeprazole can also affect the bioavailability of those drugs whose absorption is related to the pH level. Omeprazole prevents the destruction of drugs that exhibit sensitivity to acid.
With simultaneous treatment with itraconazole or ketoconazole and omeprazole, a decrease in the rate of adsorption of other drugs may be induced.
The effect of domperidone can neutralize anticholinergic drugs.
Bioavailability of domperidone with simultaneous treatment reduces antisecretory and antacid agents
Domperidone reduces hypoprolactinemia, which manifests itself in the treatment with bromocriptine.
The concentration of domperidone in the blood increases with its simultaneous administration with antifungal agents of the azole series, HIV protease inhibitors, macrolide antibiotics.

Terms of sale

To buy Omega DSR onlin you don't need a prescription.

Storage conditions

It should be protected from moisture and light, stored at a temperature of 25 degrees Celsius.
Shelf life - 2 years.

special instructions

It is necessary to exclude malignant diseases, as well as other severe diagnoses even before the beginning of treatment, since the drug can mask the signs of these diseases and make diagnosis more difficult.
In the treatment of medicines that reduce acidity, the risk of developing gastrointestinal infections triggered by certain microorganisms (Campylobacter, Salmonella) may increase.
In people with pheochromocytoma in treatment, the likelihood of developing a hypertensive crisis increases.
The ability to concentrate attention to drug treatment has no effect.

Children

It is contraindicated for the treatment of children this drug.

In pregnancy and lactation

There is no exact information on the safety of the drug for pregnant and lactating mothers. Therefore, in such conditions, Omese DSR is not used.

Reviews

Reviews about Omese DSR testify to its effectiveness. The drug quickly removes the symptoms of gastroesophageal reflux disease. Patients taking the drug for a long time, noted a marked improvement in health status.