Nexium pellets&granules 10mg #28

Nexium instruction

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Composition

The composition of the tablets of esomeprazole magnesium trihydrate 22.3 mg or 44.5 mg + adjuvants (giproloza, E172, magnesium stearate, glycerol monostearate, hypromellose, triethyl copolymer, ethacrylic acid and methacrylic acid, macrogol, crospovidone, paraffin, polysorbate 80, fumarate sodium, macrogol, E171, sucrose, talc).
Mass, for the preparation of the solution: esomeprazole 40 mg + sodium hydroxide and disodium edetate dihydrate.

Form of issue

Nexium 20 mg and Nexium 40 mg - tablets in a shell, oblong, convex. Color - pink, 20 mg - lighter, 40 mg - darker. On one side of the tablet, the dosage is engraved, in the other - the inscription A / EH or A / EI. Cardboard packages of 7, 14, 28 pieces.
Powder is a pressed white mass for the preparation of a solution. In glass bottles of 5 ml.

pharmachologic effect

Proton pump inhibitor.

Pharmacodynamics and pharmacokinetics

The active substance is a derivative of omeprazole (its S-isomer). Esomeprazole reduces the activity of hydrochloric acid secretion in the gastric mucosa, by inhibiting the proton pump (enzyme H + K + -ATPase) parientalnyh cells on the wall of the stomach.
When combined with antibiotics, it is effective against Helicobacter pylori, which is usually the cause of stomach ulcers.
As a specific response to a decrease in acid secretion, benign cysts can be formed, and the level of gastrin in the plasma can increase.
After 1-2 hours after taking the drug has already begun to have an active effect on the level of hydrochloric acid. Approximately 90% of the active substance is absorbed into the blood plasma proteins. Metabolised, excreted in urine and feces.
Pharmacokinetics in people with a decreased activity of the enzyme CYP2C19 and severe liver disease is different from the main group of people. It is necessary to correct the dose of the medicine.

Indications for use

Pills:
    erosive reflux-esophagitis, treatment and maintenance therapy;
    ulcer of the stomach and duodenum (treatment and prevention, in combination with other drugs);
    pathological hypersecretion of the glands of the stomach;
    people who take NSAIDs for a long time and treat diseases caused by their intake;
    prevention and treatment of bleeding from the peptic ulcer;
    idiopathic hypersecretion.
A solution for intramuscular administration is prescribed if it is not possible to take the tablet form of the preparation.
The indication is:
    gastroesophageal reflux disease;
    peptic ulcers, including the prevention of bleeding after endoscopic hemostasis.

Contraindications

Before you buy Nexium you should know that the drug is contraindicated:
    patients with allergies, on any of the components, including fructose (for tablet form);
    when taking atazanavir or nelfinavir;
    children under 12 years.
In the case of gastroesophageal reflux disease, the medicine can be prescribed for children over 12 years of age.
Severe kidney failure is not a direct contraindication to the use of the drug, but in this case, you should be careful.

Side effects

    nausea, headache, constipation, pain in the epigastric region;
    allergic reactions to the skin, violation of sleep, paresthesia;
    bronchospasm, stomatitis, anaphylactic shock, myalgia, agitation, arthralgia;
    possible inflammation and redness at the injection site for intravenous and intramuscular use.

Instructions for use Nexium (Method and dosage)

Tablets drink whole or dissolve in water without gas. If necessary, a dissolved tablet can be administered via a nasogastric tube.

How to take, before meals or after?

According to the instructions for use Nexium, food intake does not affect the effectiveness of the drug. In the treatment and prevention of ulcers, as a rule, the daily dose of the drug is 20 mg, is divided into two doses in combination with other agents. The course is 7 days.
When performing acid-suppressing therapy, Nexium 40 mg is prescribed, every day for a month.
In states caused by the intake of NSAIDs, the daily dosage is 20-40 mg. The rate is up to two months.
In severe liver disease, the daily dose should not exceed 20 mg.

Dosage for children (12+)

With erosive reflux-esophagitis, the daily dose is 40 mg, at one time, one month. In other cases, 20 mg of the drug per day is sufficient.

Intramuscular injections

If necessary, injections of the drug or intravenous infusions may be given instead of the tablet form. The dosage is the same. The time of intramuscular injection should be at least three minutes.
Intravenous - from 10 minutes to half an hour. The drug is diluted 0.9% of sodium chloride, not mixed with other drugs.
Store the prepared preparation for no more than 12 hours, it is best to use it immediately after preparation.

Overdose

People who consumed 0.28 grams of the drug showed weakness and discomfort in the gastrointestinal tract.
The medicine does not have a specific antidote. Treatment is symptomatic.

Interaction

When esomeprazole is combined with preparations such as ketoconazole and intraconazole, the absorption of drugs from the gastrointestinal tract may be impaired.
Atazanavir, nelfinavir, omeprazole when combined with Nexium become less effective. However, when combined with saquinavir, its concentration in the serum increases.
Simultaneous reception with funds in the assimilation of which CYP2C19 participates will lead to an increase in their effect. These drugs include imipramine, diazepam, clomipramine, citalopram, phenytoin.
For people suffering from epilepsy, caution should be taken. Medications for epilepsy (phenytoin) do not fit well with Nexium.
With caution combine the drug with warfarin and cisapride.

Storage conditions

Dark, cool place, away from children.
The bottle with powder is stored in the original packaging, in the light - no more than a day.

Shelf life

3 years - tablets.
2 years - powder for solution.

Which is better: Pariet or Nexium?

In general, the question of the use of a particular remedy should be determined individually, depending on the results of the analyzes, the sensitivity of the organism to one or another remedy. However, among experts there is an opinion that Pariet is somewhat more effective than Nexium. Its effect comes faster, the daily dosage is less, and the side effects are less frequent. Both funds are expensive, which is fully justified by their effectiveness.

Reviews about Nexium

Reviews of doctors about Nexium: In general, inhibitors of the proton pump are the most effective drugs at the moment, regulating acidity in the gastrointestinal tract. Nexium is a very good drug of this series, with a pronounced strong therapeutic effect.
Reviews on the forums are good. The medicine is effective enough, relief comes quickly. Side effects are rare. The disadvantage is high cost.