Pariet tabs 20mg #14

User manual for Pariet pills

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Composition

The tablets contain the active ingredient: rabeprazole sodium.
Additional constituents: manite, magnesium oxide, hydroxypropylcellulose, hydroxypropyl cellulose, magnesium stearate, ethyl cellulose, hypromellose phthalate, diacetylated monoglyceride, talc, titanium dioxide, iron oxide red, carnauba wax, gray food F6.

Form of issue

Pariet is produced in the form of tablets coated with enteric-coated shell, 10 mg, 20 mg of active substance. Tablets are packed in blisters for 7 or 14 pieces, 1-2 blisters per pack.

pharmachologic effect

For the drug is characteristic antiulcer action.

Pharmacodynamics and pharmacokinetics

Rabeprazole is an antisecretory substance derived from benzimidazole. This component is characterized by suppression of gastric juice secretion with specific inhibition of H + / K + -ATPase in the secretory surface of parietal GIT cells. In this case, H + / K + -ATPase is a protein complex functioning as a proton pump. Therefore, we can say that rabeprazole sodium is an inhibitor of the proton pump in the stomach that blocks the final stage of acid production. This effect is considered dose-dependent and causes suppression of basal and stimulated acid production, without dependence on the stimulus. For rabeprazole sodium, anticholinergic properties are not characteristic.
Absorption of rabeprazole from the gastrointestinal tract occurs quickly enough. Therefore, reaching the maximum concentration of the substance is noted after 3.5 hours with a dose of 20 mg. The absolute bioavailability is approximately 52%. Multiple administration of the drug does not affect the change in bioavailability.
In the human body, rabeprazole binds to plasma proteins by 97%. The main part of rabeprazole is excreted in urine, mainly in the form of metabolites: carboxylic acid and conjugate of mercaptur and other substances. Removal of the remainder of the drug occurs with feces and bile.

Indications for use

Indications for parietal in different dosages are somewhat different. Therefore, 10 mg tablets are administered at:
Dyspepsia caused by high acidity of the gastric juice, accompanied by heartburn and acidic eructations.
The preparation of 20 mg is recommended to be taken at:
    peptic ulcer of stomach, 12 duodenum with exacerbations;
    erosive and ulcerative gastroesophageal reflux disease and reflux-esophagitis;
    non-erosive gastroesophageal reflux disease;
    maintenance therapy of gastroesophageal reflux disease;
    Zollinger-Ellison syndrome and conditions associated with pathological hypersecretion;
    eradication of Helicobacter pylori for patients with ulcerative lesions.

Contraindications for use

The medicine is not prescribed for:
    hypersensitivity to rabeprazole;
    lactation, pregnancy;
    age to 12 years - the preparation of 10 mg, to 18 years - 20 mg.

Side effects

Clinical practice shows that in most cases the patient tolerates this medicine well. If side effects occur, they are usually mild and quickly pass, for example: headache, flatulence, abdominal pain, constipation, a feeling of dryness in the mouth, dizziness, rash, peripheral edema and so on.

Tablets Pariet, instructions for use (Method and dosage)

This medicine is intended for ingestion, in its entirety. It is noted that the activity of the main component is not affected by the time of taking or eating.
As the instruction on the application of Pariet 10 mg informs, he is prescribed to take the pill once a day, preferably in the morning before meals, as this increases the effectiveness of treatment.
Tablets of 20 mg are prescribed for complicated gastrointestinal diseases, therefore, how to take them for various violations is indicated by a specialist. In addition, with different diseases, not only a certain dosage and treatment regimen is established, but also its duration. Therefore, you should not take this medication yourself.

Overdose

Cases of overdose in clinical practice are not noted, but they should not be completely excluded. It is assumed that taking high doses of the drug may increase the severity of side effects. Treatment is carried out depending on the symptomatology.

Interaction

As a rule, the use of this drug with other drugs does not lead to significant drug interaction. However, for rabeprazole sodium is characterized by a stable and prolonged suppression of gastric juice production. It is possible to interact with components whose absorption has a pH dependence.
The combination with ketoconazole reduces its absorption by 30%, and in digoxin it increases by 22%. For this reason, dosage adjustment is necessary in the direction of decrease or increase.
Simultaneous reception of rabeprazole sodium with fatty food often slows its absorption by 4 or more hours, without affecting its concentration in the body. Combinations with methotrexate, especially at higher dosages, increase its concentration or metabolite - hydroxymethotrexate by almost 2 times.

Terms of sale

To buy Pariet online you don't need a prescription.

Storage conditions

To store the drug requires a dry, cool and dark place, inaccessible to children.
Shelf life - 2 years.

Alcohol

There is no direct contraindication to alcohol consumption when taking these tablets. However, the indications for which treatment is prescribed by Pariet, recommend not to drink alcohol.

Reviews about Pariet

In most cases, reviews about Pariet are related to its effectiveness. As you know, it is prescribed for the treatment of gastritis, ulcers, heartburn and so on. It is reported that even when the acidity decreases temporarily, it already helps in restoring the health of the digestive tract.
However, the responses of those who took Pariet are not always positive. There are stories that treatment with this drug did not bring the expected results - pain and heartburn persist. In the opinion of specialists, this can indicate both an incorrectly diagnosed diagnosis and an improperly prescribed therapeutic regimen. Therefore, patients should not continue to suffer from unwanted symptoms, but you need to contact a specialist.
In addition, for Pariet, as well as other drugs for the treatment of the gastrointestinal tract, selective efficacy is characteristic, which manifests itself in different ways in various disorders. This means that it can only be taken with an accurately diagnosed diagnosis.