Mesacol tabs 400mg #50

User manual for Mesacol

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Composition

In 1 tablet of mesalazine 400 mg. Calcium hydrophosphate, corn starch, MCC, hypromellose, povidone, talc, silicon dioxide, methacrylic acid, sodium carboxymethyl starch, dibutyl phthalate, iron oxide, titanium dioxide, red, macrogol as auxiliary substances.

Form of issue

Tablets in a shell dissolving in the intestine, 400 mg.

pharmachologic effect

Antimicrobial, anti-inflammatory.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The active substance has a local anti-inflammatory effect, which is due to inhibition of the synthesis of leukotrienes and prostaglandins. It inhibits degranulation and phagocytosis of neutrophils. It has antibacterial action - it is active against cocci and Escherichia coli.

Pharmacokinetics

When ingested, the active substance begins to release after 170 minutes, and after 225 minutes the membrane completely dissolves. It is this that causes the release of 60-79% of the active substance in the large intestine. In the jejunum there is an insignificant release into the systemic blood stream, only 10% comes in, so the concentration in the blood is low. It binds to proteins by 43%. Metabolized to N-acetyl-5-aminosalicylic acid. Penetrates into the milk.
The half-life is 0.5 to 2 hours, and the metabolite is 6-10 hours. About 50% is excreted by the kidneys, the rest - by the intestine. In renal failure, cumulation is noted.

Indications for use

Treatment of Crohn's disease and nonspecific ulcerative colitis.

Contraindications

    hypersensitivity to salicylates;
    blood diseases;
    hemorrhagic diathesis;
    peptic ulcer;
    renal / hepatic impairment;
    age to 2 years.
Pregnant is prescribed if the benefit to the mother exceeds the risk to the fetus. Breastfeeding is discontinued when this medication is prescribed.

Side effects

    nausea, decreased appetite, diarrhea, vomiting, abdominal pain, stomatitis, increased levels of "liver" transaminases; pancreatitis, hepatitis;
    palpitation, tachycardia, changes in blood pressure, dyspnea, chest pains, conduction disorders;
    headache, dizziness, tremor, tinnitus, neuropathy, depression, insomnia;
    protein in the urine, hematuria, oliguria or anuria, oligospermia, single cases of impotence;
    eosinophilia, leukopenia, anemia, agranulocytosis, hypoprothrombinemia, thrombocytopenia;
    rash, itching, dermatosis, erythema, bronchospasm;
    lupus-like syndrome, photosensitivity, alopecia.

Mesacol, instructions for use (Method and dosage)

Mesacol tablets are taken orally after meals, wholly, with plenty of water.
At treatment appoint 400-800 mg three times a day. Treatment lasts up to 12 pedules. If one dose is missed, the missed dose is taken together with the next or at any other time.
For the prevention of 400 mg three times a day.
Periodic analysis of blood and urine is advisable. The color of urine can be marked in yellow. If the drug is intolerant, it is canceled.

Overdose

It manifests as nausea, vomiting, pains in the stomach, weakness and marked drowsiness.
The lavage of the stomach is carried out, laxatives and sorbents are taken, symptomatic treatment is prescribed.

Interaction

Mesalazine enhances the action of glucocorticosteroids, anticoagulants, sulfonylurea drugs and toxicity of methotrexate. Slows down the absorption of cyanocobalamin and enhances the effect of uricosuric drugs. Weakened action of rifampicin, spironolactone, furosemide and sulfonamides with simultaneous appointment with it.

Terms of sale

You don't need a prescription to buy Mesacol online.

Storage conditions

Temperature up to 25 ° С.
Shelf life - 4 years.

Reviews of Mesacol

In recent years, more commonly with NNK and Crohn's disease, 5-aminosalicylic acid preparations have been used, compared to sulfosazine. This drug is effective for light and moderate severity of NUC flow. The use of Mesacol allows controlling the course of the disease in 60% of patients. After remission is reached, the drug is used for maintenance treatment. It is successfully used as a basic therapy for this disease. Advantages of this drug are: proven effectiveness, the ability to use from 2 years, the minimum amount of side effects (compared with sulfasalazine). In the reviews, patients often compare the two above described remedies and give preference to one or the other, depending on individual tolerability and effectiveness.
    "... Personally, I had a remission of this drug. Prior to him, he drank Salofalk - without result. "
    "... I accept this one for two reasons - it is better for the large intestine and, moreover, it is cheaper."
    "... I tried both. There are fewer sideburns after Mesacol - I think from the fact that it is later released and absorbed even less. "
    "... I combine 2 drugs - I put Salofalk candles and I drink Mesacol tablets. You can not get away from the pills - it starts to aggravate. "
    "... I tried to take Mesacol, but it got worse (the liver began to ache, there was blood in the stool). Again I went to Salofalk. "
    "... I was appointed more than a year ago. I drink constantly, but in a maintenance dose, there are changes in blood. Tried to give up, but immediately the aggravation begins. That's the circle and closed. "