Pentasa tabs 500mg #50

Instruction for Pentasa tablets

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Composition

The active ingredient is mesalazine.
The tablets contain 500 mg of this substance, as well as microcellulose, povidone, talc, ethylcellulose, magnesium stearate.
Suppositories contain 1 g of active substance, as well as talcum, povidone, magnesium stearate, macrogol 6000.
100 ml of rectal suspension contain 1 g of active ingredient.
1 packet of granules contains 1 or 2 g of mesalazine.

Form of issue

Tablets of prolonged action, rectal suspension, suppositories, sustained-release granules in sachets.

pharmachologic effect

Anti-inflammatory, antimicrobial intestinal preparation.

Pharmacodynamics and pharmacokinetics

Active substance is mesalazine. In the large intestine, the antibacterial activity of the drug is manifested with respect to most species of cocci and Escherichia coli.
The mechanism of action is based on a decrease in the rate of degranulation, migration and phagocytosis of neutrophils, on the slowing down of the secretion of immunoglobulins by blood cells by lymphocytes.
Local anti-inflammatory effect is achieved due to inhibition of the synthesis of leukotrienes and prostaglandins, a decrease in the activity of neutrophilic lipoxidase.
The antioxidant effect is provided by the ability to bind mesalazine with oxygen free radicals and then destroy them.
Pentasa is well tolerated. In patients with ileitis, in the chronic course of Crohn's disease, medication can significantly reduce the risk of relapse.

Indications for use

Pentasa pills are prescribed for Crohn's disease, with an unspecified variant of ulcerative colitis.
The medication can be used for preventive purposes.

Contraindications

Pentasa is not prescribed for breastfeeding, with peptic ulcer disease, with blood diseases, with individual intolerance to mesalazine.
Instruction for use Pentasa does not recommend the prescription of medicines for children until the age of two, with severe diseases and pathology of the hepatic system and liver, during pregnancy (the last 2-4 weeks).

Side effects

Digestive system: stomatitis, dry mouth, nausea, decreased appetite, heartburn, vomiting, diarrhea syndrome, hepatitis, increased liver enzymes, pancreatitis.
Cardiovascular system: dyspnea with physical activity, fluctuations in blood pressure, tachycardia, retrosternal pain, a feeling of rapid heartbeat.
Nervous system: tremor of extremities, polyneuropathy, dizziness, tinnitus, depressive mood, migraine headaches.
The urinary system: crystalluria, hematuria, proteinuria (protein secretion), anuria (absence of urination), oliguria, formation of nephrotic syndrome.
Organs of hematopoiesis: hypoprothrombinemia, leukopenia, eosinophilia, thrombocytopenia, anemia (variants: aplastic, megaloblastic, hemolytic), diagnosis of agranulocytosis.
Also, with the use of Pentasa, the appearance of alopecia, the formation of photosensitization, oligospermia, lupus-like syndrome, mumps, weakness in the limbs, and the loss of lacrimal fluid production are possible.

Pentasa, instructions for use (Method and dosage)

Depending on the extent of the intestinal lesion, the localization of the main process depends on the choice of the dosage form.
Pentasa suppositories are prescribed for distal forms of the disease: proctosigmoiditis. Suppositories are prescribed thrice a day for 500 mg.
Pentasa pills are recommended for use in common forms of illness.
Prevention of relapse in Crohn's disease: four times a day for 1 gram of mesalazine.
Prevention of recurrence of nonspecific ulcerative colitis: three times a day for 400-500 mg.
Exacerbation of the disease: the course is designed for 8-12 weeks with a daily three-time intake of 400-800 mg of the drug. It is possible to increase the daily dosage to 3-4 grams in severe disease. Pentasa tablets should be taken after meals, without chewing, with plenty of water.

Overdose

Characterized by increased drowsiness, gastralgia, nausea, vomiting, weakness throughout the body.
It requires timely washing of the stomach, conduction of a post-dandruff therapy, the appointment of laxative medicines.

Interaction

Pentasa slows the rate of absorption of cyanocobalamin.
Mesalazine is able to increase the effectiveness of uricosuric medicines (tubular secretion blockers).
The drug increases the toxicity of methotrexate, hypoglycemic effects of sulfonylureas, weakens the effectiveness of rifampicin, sulfonamides, spironolactone, furosemide.
Pentasa enhances the ulcerogenicity of glucocorticosteroids.

Storage conditions

In a place inaccessible to children. The recommended temperature regime for storing the medicine is not more than 25 degrees Celsius.
Shelf life is not more than two years.

special instructions

When medication is missed, the missed dose of mesalazine should be taken with the next dose or soon. If several doses are missed at once, an urgent medical consultation is recommended; no self-termination of treatment is allowed.
In some cases, staining of contact lenses and urine in a yellowish-orange hue is observed.
It requires regular monitoring of the kidney system, urine, blood must be analyzed throughout the course of treatment and at the conclusion of it.
The likelihood of side effects increases in patients who are "slow acetylators".
When forming an acute syndrome of intolerance to the active ingredient, the Pentasa preparation is canceled.

Reviews about Penthouse

Comments on the drug indicate the high effectiveness of mesalazine in the therapy and prevention of ulcerative colitis, Crohn's disease.

Terms of sell

To buy Pentasa the prescription is not required.