Salofalk suppositories rectal 250mg #10

Salofalk suppositories instruction

You can buy Salofalk suppositories here

Composition and form of release

The drug Salofalk is released in the dosage form of a suppository (suppository) for rectal (into the cavity of the rectum) application. They have a white, cream-colored color, a torpedo shape, small dimensions and a smooth surface. The main active substance of the drug is mesalazine (5-ASA), its content in one suppository is 0.25 and 0.5 g. Also the Suppositories contains auxiliary substances, which include:
    Gaseous nitrogen.
    Xanthan gum.
    Ethylaminoacetate of sodium.
    Disulfite of potassium.
    Carbomer.
    Potassium acetate.
    Sodium benzoate.
    Purified water.
Suppositories Salofalk packaged in a blister for 5 pieces. A cardboard bundle may contain 2 or 6 blisters with an appropriate number of Suppositories and instructions for use.

Pharmacodynamics and pharmacokinetics

The main active component of suppositories Salofalk mesalazine has a pronounced anti-inflammatory therapeutic effect, which is realized by reducing the concentration of prostaglandins, leukotrienes and other proinflammatory mediators in the focus of the pathological process. These mediators increase the permeability of the walls of the vessels of the microcirculatory bed with the release of plasma into the intercellular substance of the tissues and their edema, irritate sensitive nerve endings with painful sensations. Also, mesalazine has an antioxidant effect, which is realized through the binding of free radicals, which are fragments of organic molecules possessing pronounced chemical activity and destroying the cell membranes.
After rectal administration of the Salofalk suppository into the rectal cavity, the active ingredient is well adsorbed into the tissues of the intestinal mucosa, where it has a therapeutic effect. Partially it is absorbed into the systemic bloodstream, where it does not accumulate for the necessary therapeutic effect.

Indications for use

Medical use of suppositories Salofalk is indicated for the treatment and prevention of exacerbation of ulcerative colitis and Crohn's disease (pathological processes characterized by noninfectious inflammation of the mucous membrane of the colon with the formation of small defects in it in the form of ulcers).

Contraindications for use

There are a number of absolute medical contraindications, in which the use of suppositories of Salofalk is excluded, these include:
    Different pathology of the blood system (leukemia, anemia).
    Deficiency of the enzyme glucose-6-phosphate dehydrogenase, which affects the functional state of the erythrocyte membrane.
    Severe insufficiency of the functional activity of the liver and kidneys.
    Ulcerous pathology, characterized by the formation of mucosal defects with localization in the stomach or duodenum.
    Phenylketonuria is a pathological metabolic disorder with the appearance of ketone bodies (acetone) in the urine.
    The patient's age is up to 6 years.
With caution, the drug is used with concomitant deficiency of the functional activity of the liver or kidneys of moderate severity, pregnancy in the early stages of the course (I trimester), lung pathology, in particular bronchial asthma. Before starting the use of Salofalk Suppositories, it is important to make sure that there are no medical contraindications.

Dosing and Administration

Suppositories Salofalk are intended for introduction into the cavity of the rectum (rectal application). The average dosage of the drug for adults is 0.5 g 3 times a day. In the severe course of the pathological process, the dosage can be doubled. For preventive purposes, the dosage of the drug is 250 mg once a day. Children older than 6 years with a body weight of less than 40 kg dosage is reduced by half. The duration of the course of treatment with the drug is prescribed by the doctor individually.

Side effects of Salofalk suppositories

Against the background of the use of Salofalk Suppositories, it is possible to develop negative pathological reactions from various organs and systems:
    Digestive system - decreased appetite, periodic nausea, abdominal pain, diarrhea, bloating (flatulence), inflammation of liver tissues (hepatitis), elevated enzyme level of hepatic transferase in the blood, indicating damage to liver cells (hepatocytes).
    Nervous system - long-term depression of mood (depression), headache, periodic dizziness, general weakness, sleep disturbances, trembling (tremor) of the hands, tinnitus, seizures, sensitivity of various areas of the skin (paresthesia).
    Cardiovascular system - increased heart rate (tachycardia), changes in systemic blood pressure (increase or decrease).
    The urinary system is the appearance of blood (hematuria) and protein (proteinuria) in the urine.
    Skin and its appendages - hair loss (alopecia).
    Allergic reactions - a rash on the skin, itching, swelling and eruptions, reminiscent of a nettle burn (urticaria), pronounced edema of soft tissues with predominant localization in the face and external genital organs (angioneurotic edema of Quincke), narrowing of the bronchi (bronchospasm).
The appearance of negative pathological reactions against the background of the application of suppositories Salofalk is the basis for correction of the dosage of the drug or its withdrawal.

special instructions

Before prescribing the suppositories of Salofalk, the doctor must take into account several specific indications regarding the use of the drug, which include:
    It is recommended that the drug be administered only under the supervision of the attending physician.
    Before the start of the course of therapy, against the background of the drug, as well as after its withdrawal, periodic blood and urine tests should be performed.
    With prolonged use of suppositories Salofalk recommended periodic monitoring of the functional state of the liver and kidneys.
    The drug may interact with drugs from other pharmacological groups, so if they are used, the doctor should be warned.
    The possibility of using suppositories Salofalk for pregnant women in later stages of the course or during lactation (breastfeeding) is determined only by a doctor under strict medical conditions.
    The drug does not have a direct effect on the cerebral cortex, however, against the background of its use, it is not recommended to perform work that is associated with increased concentration of attention and sufficient speed of psychomotor reactions.
In the pharmacy chain, suppositories of Salofalk are dispensed on prescription. Their independent use is excluded without the appropriate medical purpose.

Overdose

In case of a significant excess of the recommended therapeutic dose of suppositories Salofalk appears nausea, drowsiness, general weakness, vomiting. Treatment of overdose is only symptomatic, since there is no specific antidote for the active ingredient of the drug.

Terms and conditions of storage

Shelf life of suppositories Salofalk is 3 years from the date of manufacture. The preparation should be stored in the original factory packaging, dark, dry, inaccessible to children at an air temperature of no higher than 25 ° C.

Terms of sell

You don't need a prescription to buy Salofalk suppositories