Phosphogliv caps 65mg + 35mg #50

Phosphogliv instruction for use

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Composition

Each capsule contains 65 mg of phospholipids and 35 mg of sodium glycyrrhizinate as active ingredients.
Excipients:
    microcrystalline cellulose;
    calcium carbonate;
    calcium stearate;
    talc;
    colloidal anhydrous silicon dioxide.
Capsule shell composition:
    titanium dioxide;
    black iron oxide;
    dye E 110;
    gelatin.
In each vial of lyophilizate, 500 mg of phospholipids and 200 mg of sodium glycyrrhizinate are used to prepare the solution for intravenous administration.

Form of issue

The drug is available in two forms:
    Capsules. The capsule case is orange, and the lid is black. Inside there is a light powder with a weak yellow tint. There is a weak specific smell. Capsules are placed on 10 pieces in blisters. Blisters are laid out on 5 in cardboard packs.
    Liofizilat for IV introduction. It looks like white or light yellow mass. It is placed in bottles of 2.5 g. Vials of 5 or 10 pieces are laid out in cardboard packs.

pharmachologic effect

Refers to hepatoprotectors. Used to treat liver and skin diseases.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Active substances, in particular phospholipids, restore the structure and function of liver cells. They affect the cell wall and other structural elements of hepatocytes, correct the protein and lipid metabolism in these cells.
In addition, glycyrrhizic acid acts depressingly on the reproduction of viruses, stimulating the production of interferons. It also has antioxidant and membrane stabilizing activity. This effect extends not only to liver cells, so the drug is effective for improving the skin condition.

Pharmacokinetics

In case of ingestion in the form of capsules, the drug is well absorbed through the walls of the digestive tract in the intestine. The maximum concentration in the blood is reached after 6-24 hours. Excretion occurs with bile and urine.
With IV administration, the drug immediately enters the systemic circulation, the maximum concentration is reached earlier. The mechanism of action on the body and excretion are the same as when taking the medicine inside.

Indications for use

From what tablets Phosphogliv (INN - comb drug) usually well help:
    Hepatitis caused by infection with the virus (used in both acute and chronic forms);
    hepatosis of the liver (fatty degeneration);
    liver damage caused by ingestion of toxins, alcohol, certain medicines;
    cirrhosis;
    various intoxications;
    skin diseases (psoriatic rashes, eczema, neurodermatitis).

Contraindications

It is counter-indicative to apply Phosphogliv in such cases:
    excessive sensitivity to the components of the drug;
    any term of pregnancy;
    the period of breastfeeding;
    antiphospholipid syndrome;
    age younger than 12 years.
Caution should be exercised when prescribing a medicament to persons with a tendency to increase blood pressure.

Side effects

Side effects of Phosphogliv appear infrequently.
Possible unwanted effects:
    rash on the skin;
    hypersensitivity reactions of mucous membranes, manifested in the form of cough, conjunctivitis, small stuffiness of the nose;
    digestive disorders, belching, nausea, bloating;
    Edema on the peripheral parts of the body;
    transient increase in blood pressure.

Instructions for use Phosphogliv (Method and dosage)

The medicine in capsules is prescribed after reaching the age of 12 years.
The drug is taken 1 or 2 capsules 3-4 times during the day. Reception is carried out while eating. After they drank the medicine, it should be taken with water.
The course of treatment lasts up to six months. The average duration is 3 months.

Overdose

No reported cases of overdose.
The composition includes glycyrrhizic acid. When ingested in large quantities, it can have a pseudocorticosteroid effect. This increases the content of glucocorticoids and mineralocorticides in the blood. Because of this, sodium can stay in the body and the amount of potassium may decrease. Clinically, such processes will be manifested by increased blood pressure, fluid retention, and swelling of the peripheral parts of the body.

Interaction

Glycyrrhizic acid interacts with corticosteroid hormones. It is their synergist, that is, enhances their action and increases its duration.

Storage conditions

Store in accordance with the requirements for storage of preparations belonging to list B.
The storage location should be well protected from light.
The required temperature is up to 20 ° C.
Capsules can be stored for 3 years, ampoules - 2 years.

special instructions

Care must be taken when treating patients with a diagnosis of portal or hypertension. If as a result of taking Phosphogliv increases the pressure, you need to stop therapy and consult with your doctor.
A solution prepared on the basis of a lyophilisate is categorically prohibited from mixing with any other solutions for intravenous administration, including isotonic and glucose solution.

Children

It is allowed to use only when treating people who have reached the age of 12.

With alcohol

Phosphogliv and alcohol have opposite effects on liver cells. Alcohol will slow the regeneration of hepatocytes, and in large doses will destroy all the results of treatment.
But there is no interaction between alcohol-containing drinks and active ingredients, so a single intake of a small amount of alcohol should not affect your well-being in any way.

In pregnancy and lactation

During pregnancy and lactation, Phosphogliv should not be taken.

Reviews about Phosphogliv

Reviews of Phosphogliv on the forums

In most cases, forum users write about the drug as an effective means of fighting liver problems. It helps to cope with unpleasant symptoms of violations of the liver, as well as well-being, and the results of tests. This was noted by patients and serious diseases, for example, with hepatitis C, Phosphogliv also works well. Also, reviews show that Phosphogliv improves skin condition. In addition, the drug is relatively inexpensive.
A small number of negative reviews are associated with the fact that not in all cases of taking medication it is obtained to achieve the desired effect.

Doctor's comments

Basically, reviews about Phosphogliv are good. It is actively used to treat liver damage of various etiologies. It is noted that this drug is effective for hepatitis C.
In addition to treating liver diseases, the drug is able to positively influence the condition of patients with certain skin diseases. For example, it is prescribed for psoriasis.