Pilobact caps/tabs #7

Pilobact instruction for use

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Composition of the Pilobact

Each blister contains 2 capsules of omeprazole in a dose of 20 mg, 2 tablets of tinidazole at a dose of 500 mg and 2 tablets of clarithromycin in a dose of 250 mg.

Form of issue

Blisters with 6 capsules and tablets.

pharmachologic effect

Antiulcer.

Pharmacodynamics and pharmacokinetics

In its composition contains three active components - omeprazole, tinidazole and clarithromycin. The drug has antiulcer and antimicrobial effects. Under the influence of omeprazole, the secretion and acidity of hydrochloric acid decreases (due to the inhibition of a special enzyme located in membranes of parental cells in the mucous wall of the stomach), the level of stimulated and basal secretion decreases. Oral administration of omeprazole oppresses the secretion of gastric juice after an hour, the effect persists for a day. Reduction of the acidity of gastric juice by 97% is achieved by the repeated intake of 20 mg of omeprazole during the day.
The second component of the Pilobact preparation is clarithromycin - a semi-synthetic derivative of erythromycin A, an antibiotic of the macrolide group, acts on helicobacter pylori, anaerobic microorganisms, gram-negative and gram-positive flora.
The third component of the preparation is Pilobact - tinidazole; acts on ljamblii, amoeba, Trichomonas, helikobakter pylori, causative agents of anaerobic infection, possesses protivoprotozojnym influence.
Pilobact AM additionally contains amoxicillin (antibiotic). Pilobact NEO is used for triple helikobacter therapy.

Indications for use

Instructions for use Pilobact recommends the appointment of a medicine for peptic ulcer of the digestive tract (stomach, duodenum) in order to eradicate Helicobacter pylori.

Contraindications

Pilobact is not prescribed for porphyria, breastfeeding, chronic diseases of the hepatic system, intolerance to active components (omeprazole, tinidazole, clarithromycin, for Pilobact AM - amoxicillin), with pregnancy, severe renal, hepatic insufficiency, with ethanol (increases the risk of development of disulfiramoid reactions), children up to the age of twelve.

Side effects

The omeprazole, which is part of the Pilobact, can cause headaches, increased gas formation, diarrheal syndrome, weakness, dizziness, epigastric pains, constipation, nausea, thrombocytopenia, increased liver enzyme levels, eosinocytopenia, neutropenia, leukopenia, skin rashes.
Tinidazole can cause cholestatic jaundice, gastralgia, nausea, headache, allergic reaction in the form of itching and rash, pseudomembranous enterocolitis, diarrhea, vomiting, development of the secondary stability of microbial flora. Side effects of tinidazole: skin itching, vomiting, leukopenia, an unpleasant aftertaste in the oral cavity, anorexia, headaches, hives.

Pilobact, instructions for use (Method and dosage)

The medicine is taken internally.
Each blister contains 2 capsules of omeprazole in a dose of 20 mg, 2 tablets of tinidazole at a dose of 500 mg and 2 tablets of clarithromycin in a dose of 250 mg.
Each blister is designed for 1 day of antiulcer therapy. According to the instruction, one capsule of omeprazole, 1 tablet of tinidazole and 1 tablet of clarithromycin should be taken in the morning (capsule and tablets are located in the orange part of the blister), in the evening the procedure is repeated (capsule and tablets are located in the blue part of the blister).
Each package contains 7 blisters, designed for a weekly course of antiulcer therapy.
After completion of treatment, it is recommended to take omeprazole at a dose of 20 mg per day for three weeks.

Overdose

When overdosed with clarithromycin, headaches, nausea, confusion may occur. It is required to rinse the stomach and treat for symptoms. Hemodialysis has no effect.
In case of an overdose of amoxicillin, vomiting, diarrhea and disturbances in the water-electrolyte balance are noted. It is required to wash the stomach, hemodialysis, activated charcoal.
In case of an overdose of tinidazole, symptom management and hemodialysis are used.

Interaction

Clarithromycin, which is part of the preparation of Pilobact, can cause an increase in the level of theophylline, terfenadine in the blood (an extension of the QT interval is recorded on the ECG).
An increase in the effect of the drug is observed with simultaneous therapy with oral forms of anticoagulants.
When treatment with digoxin, astemizole, phenytoin, carbamazepine, cisapride, pimozide, valproate, lovastatin, disopyramide, cyclosporine, an increase in the concentration of the above described drugs is observed.
Omeprazole is able to reduce the rate of metabolic processes when taking diazepam and phenytoin.
Pilobact reduces the absorption of iron salts (decrease in acid production in the stomach), ampicillin, ketoconazole.

Terms of sale

You don't need a prescription to buy Pilobact online.

Storage conditions

In a dry place inaccessible to children at a temperature of no more than 25 degrees Celsius.
Shelf life not more than two years.

special instructions

Tinidazole can cause a dark color in the urine.
Throughout the course of antiulcer therapy, a complete refusal to take alcohol-containing drinks is required because of the risk of developing disulfiram-like reactions.
With chronic pathology of the hepatic system, periodic monitoring of the level of liver enzymes is required.
Before starting therapy, the doctor should exclude the presence of malignant neoplasms (omeprazole may mask the clinical manifestations of cancer).

Reviews about Pilobact

The doctors' reviews of Pilobact testify to the effectiveness of the drug in antiulcer therapy. The drug destroys bacteria during a week course, promotes the healing of ulcers. Relapses do not occur.