Rebagit tabs 100mg #30

Instruction for Rebagit

You can buy Rebagit here

Form of issue

The tablets covered with a film membrane of white or almost white color, round, biconcave.

Composition of Rebagit

    1 tab .:
    rebamipide 100 mg.
    Excipients: mannitol 35.7 mg, croscarmellose sodium 14 mg, pregelatinized starch 80.7 mg, sodium lauryl sulfate 2 mg, citric acid 2.3 mg, talc purified 3.1 mg, magnesium stearate 2.2 mg.
    The composition of the film shell: hypromellose - 2.77 mg, talc purified - 0.57 mg, titanium dioxide - 1.11 mg, propylene glycol - 0.55 mg.

pharmachologic effect

Clinical and pharmacological group: Gastroprotector
Pharmacotherapeutic group: Gastroprotective agent

pharmachologic effect

Rebambid increases the content of prostaglandin E2 (PGE2) in the gastric mucosa and increases the content of PGE2 and GI2 in the contents of gastric juice. Has a cytoprotective effect against the gastric mucosa with the damaging effects of ethanol, acids and alkalis, acetylsalicylic acid. Promotes the activation of enzymes that accelerate the biosynthesis of high-molecular glycoproteins, and increases the mucus content on the surface of the stomach wall. It promotes blood circulation to the gastric mucosa, activates its barrier function, activates the gastric acid secretion, strengthens the proliferation and metabolism of gastric epithelial cells, cleans mucosa from hydroxyl radicals and suppresses superoxides produced by polymorphonuclear leukocytes and neutrophils in the presence of Helicobacter pylori, protects the gastric mucosa from infection by bacteria, has a gastroprotective effect when exposed to the mucosa of NSAIDs.

Pharmacokinetics

Suction and distribution

After taking a dose of 100 mg Cmax is achieved after approximately 2 hours and is 340 ng / ml. Repeated drug administration does not lead to its cumulation in the body.
In vitro experiments it was shown that from 98.4% to 98.6% of Rebagit is bound by plasma proteins.

Metabolism and excretion

T1 / 2 is approximately 1.0 h. About 10% of Rebagit is excreted by the kidneys, mostly unchanged. When administered at a dose of 600 mg, it is possible to isolate traces of a hydroxylated metabolite.
Rebagit, indications for use
- stomach ulcer;
- a chronic gastritis with the raised acid-forming function of a stomach in a phase of an exacerbation, an erosive gastritis;
- prevention of mucosal lesions on the background of NSAID administration;
Can be used in combination therapy.

Contraindications

- individual intolerance to ribabipid or other components of Rebagit;
- Pregnancy;
- lactation period;
- age to 18 years.

Dosing and Administration

Inside, 1 tablet 3 times / day, washed down with a small amount of liquid. The course of treatment is 2-4 weeks, if necessary, can be extended to 8 weeks.
The drug does not have the features of the action at the first reception or upon its cancellation.
If you miss a dose, you need to take the next dose of Rebagit at the set time, do not take twice the dose of the drug.

Application in pregnancy and lactation

The safety of the use of rebamipide during pregnancy is not proven. Do not use during pregnancy.
Since rebamipide is excreted in breast milk, breastfeeding should be discontinued or the issue of infant feeding should be resolved if it is necessary to prescribe a rebamipide mother during breastfeeding.

Side effects

On the part of the digestive system: constipation, flatulence, diarrhea, nausea, vomiting, pain in the abdomen, a violation of taste sensations, heartburn.
From the liver: signs of liver dysfunction, increased serum ALT and ACT.
On the part of the hematopoiesis system: leukopenia, granulocytopenia.
Other: violation of the menstrual cycle.

special instructions

Impact on the ability to drive vehicles and mechanisms

The effect of Rebagit on the rate of psychomotor reactions and / or the ability to control vehicles or mechanisms has not been studied. In case of taking the drug should be cautious about driving the car and other activities that require increased concentration of attention.

Drug Interactions

With the use of rebamipide in the traditional therapy regimens of patients with Helicobacter pylori infection, the effectiveness of eradication therapy is significantly increased.
Reactions with other drugs have not been studied.

Overdose

Symptoms of an overdose with rebamipide are not described, until today information about cases of deliberate overdose has not been reported. There may be nausea, vomiting, abdominal pain, diarrhea or constipation, headache.
Treatment: a specific antidote is unknown. In case of an overdose, wash the stomach and perform symptomatic therapy.

Storage conditions

Rebagit should be stored out of reach of children, dry, protected from light, at a temperature of no higher than 25 ° C.
Shelf life - 2 years.

Terms of sell

You don't need a prescription to buy Rebagit online.