Sodium thiosulfate solution 30% 10ml #10

Sodium thiosulfate instruction

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Composition

In one ampoule with 10 ml of the injectable solution contains 3 g of sodium thiosulfate.
Auxiliary substances: sodium bicarbonate and water d / and.

Form of issue

    sterile solution for intravenous administration 30%;
    60% solution (used to treat scabies);
    powder.

pharmachologic effect

Antidote. Complexing agent. Provides antiscabic, antiparasitic, anti-inflammatory, detoxifying and desensitizing effects.

Pharmacodynamics and pharmacokinetics

Sodium thiosulfate - what is it?

Sodium thiosulfate is a salt of thiosulfuric acid and sodium, which is used as an antihistamine and detoxifying agent.
Forms weakly toxic or absolutely harmless for the organism compounds with cyanides, halogens, salts of heavy metals. A solution of sodium thiosulfate in medicine has been used as an antidote to I, Hg, Cr, phenols, aniline, sulem, benzene, hydrocyanic acid.
The formula of sodium thiosulfate. - Na2SO3S or Na2S2O3.

Pharmacodynamics

When poisoning with Pb, Hg, As compounds, non-toxic sulphites are formed. When poisoning with hydrocyanic acid (cyanic acid) and its salts, detoxification is carried out by utilizing cyanide.
The latter, with the participation of the enzyme rhodonase, which shows maximum activity in the liver, is converted into a relatively non-toxic thiocyanate ion.
The organism is also capable of neutralizing cyanides, however, natural purification is very slow: the activity of the pedonase system with cyanide poisoning for detoxification is not enough.
To stimulate the reaction catalyzed by rhodonase, exogenous sulfur donors (in particular, sodium thiosulfate) are introduced into the body.
Anti-scratch activity is due to the ability of sodium thiosulfate in acidic medium to decompose into sulfur dioxide and sulfur. Both these substances are destructive for adults of the itch mite and for its eggs.

Pharmacokinetics

After the introduction of the drug into the vein, sodium thiosulfate is distributed in the extracellular space, from the body is excreted by the kidneys unchanged. Biological T1 / 2 - 0.65 hours.
The substance is non-toxic. Studies conducted on dogs showed that with constant infusion of the drug hypovolemia occurs. Reduction of BCC, most likely, is due to the osmotic diuretic effect of the drug.
It is used in a complex of means for eliminating the effects of poisoning in patients with alcoholic delirium.

Indications for use

As an antidote, the drug is used for intoxication with salts I and Br, Pb, As, Hg, cyanides and cyanic acid. Also it is prescribed for red lupus, scabies, neuralgia, arthritis, allergic diseases.

Contraindications

The only contraindication to purifying the body by means is hypersensitivity to its active substance.

Side effects

Reactions of hypersensitivity. When the drug is injected intravenously, side effects can be expressed as pain in the injection site.

Sodium thiosulfate: instructions for use

It is applied externally, intravenously and orally.
External application is indicated for scabies. According to the instructions for sodium thiosulfate, a solution of 60% should be rubbed into the skin of the limbs and trunk, and then, when it dries, moisten the treated surfaces with a solution of hydrochloric acid 6%.
Sodium thiosulfate intravenously and internally is used to purify the body during intoxication.
Sodium thiosulfate IV is administered as a 30% solution. The dose varies from 5 to 50 ml and depends on the severity of intoxication and the type of poison.
For oral administration, use a 10% solution. Single dose - 2-3 grams of sodium thiosulfate.

Sodium thiosulfate in gynecology

With gynecological pathologies the drug is used, as a rule, as a supplement to the main treatment.
Sodium thiosulfate in gynecology is intravenously administered as part of programs for the treatment of endocrine infertility. In this case, the patient is also given injections of Actovegin intramuscularly, plasmapheresis and transorbital electrophoresis of nicotinic acid.
To eliminate cysts in the ovaries for the drug used in combination with Dimexide, Vishnevsky ointment and Diclofenac.
In genital tuberculosis it is included in nonspecific therapy: the patient is prescribed enzyme preparations (ronidase or lidase), antioxidants (vitamin E) and sodium thiosulfate. The latter is injected into a vein 10ml every other day or once or twice a day. For the course of treatment a woman should receive from 40 to 50 infusions of the drug.
In some cases, sodium thiosulfate is used in the form of microclysters. Some doctors recommend this method of treatment for adhesions in the small pelvis and inflammatory diseases of the reproductive system.
The procedure is carried out using a 10% solution. Single dose - 30-50 ml. Before entering the anus, the solution is heated to a temperature of 37-40ºC in a water bath. It should be remembered that this is not a cleansing enema, therefore, the drug must completely absorb into the body through the intestinal mucosa.
Feedback suggests that the use of the drug in endometriosis as an anti-inflammatory and resorptive is a good alternative to hormone treatment.
An important property of the drug is the ability to prevent the development of allergic reactions that may occur during the comprehensive treatment of certain women's diseases.
The versatility of the use of sodium thiosulfate allows us to choose the most suitable method of application in each case: in the form of microclysters, intravenously or during the physiotherapy procedures (electrophoresis).

Sodium thiosulfate in psoriasis

With psoriasis, the advisability of using sodium thiosulfate is explained by the fact that the drug can thoroughly clean the body, and this in turn helps to strengthen the immune system and alleviate the course of most chronic diseases.
Reviews of people who took the solution, indicate a significant improvement in their condition. Individual patients claim that by taking sodium thiosulfate, they managed to completely get rid of psoriasis.
Nevertheless, given the chronic nature of the disease, we can assume that it is about achieving a stable remission.
How does the drug work? First, getting into the intestines, sodium thiosulfate attracts the products of vital activity and toxic substances that enter the digestive tract from the lymph, blood, intercellular and interstitial fluid.
Secondly, due to the presence of sulfur molecules, which have a pronounced restoring effect, it well binds heavy metals.
Thirdly, sodium thiosulfate enhances intestinal peristalsis and promotes the liquefaction of its contents, thus providing a laxative effect and accelerating the excretion of toxins from the body. As a result, the internal organs and systems begin to function better in the patient's recovery.
In addition, the drug slows the absorption of toxic substances through the intestinal mucosa and prevents them from entering the bloodstream.
The course of treatment of psoriasis with sodium thiosulfate lasts from 5 to 12 days. The daily dose is 10-20 ml (depending on the tolerability of the drug and the patient's body weight).
Before taking the solution diluted in 100 ml of water. To improve the unpleasant taste in it, you can add a small amount of lemon juice. Drinking a medicine is better at night. With a pronounced laxative effect, the dose is reduced to 10 ml / day.

How to drink sodium thiosulfate?

Inside the drug is taken to cleanse blood and lymph. Such treatment can improve overall health, as well as the condition of hair, nails and skin, clear the head, get rid of depression and eliminate many allergic reactions.
To clean the body, the drug is recommended to drink within 10 days. Single dose - 0.5 ampoules. Before taking the solution diluted in 100 ml of water.
The first time a remedy is taken 30-60 minutes before breakfast, the second - for 30-60 minutes before dinner or 2 hours after it.

Overdose

There are no descriptions of cases of overdose.

Interaction

Combined use with drugs, the metabolism of which involves a thrombin reaction, can lead to a weakening of the effects of the latter.
Preparations that are bromides or iodides, when combined with sodium thiosulfate, may not show their pharmacological properties.
Sodium thiosulfate can not be mixed in a single syringe with solutions of nitrates and nitrites.

Terms of sale

You don't need a prescription to buy sodium thiosulfate online at our store.

Storage conditions

The solution should be stored in a light-shielded place at a temperature of 18-20 ° C.
Shelf life - five years.

special instructions

When poisoning with cyanide, the antidote should be administered without delay, since otherwise a rapid lethal outcome is possible.
During the next 24-48 hours, the patient, due to the possibility of repeated manifestations of symptoms of cyanide poisoning, should be closely monitored. If the symptoms resume, sodium thiosulfate is re-injected in a half dose.

Qualitative reaction to sodium thiosulfate

Dry sodium thiosulfate can have a specific smell, due to which some doubt the authenticity of the substance. Some people even have a question whether they bought by mistake sodium acetate.
You can check the authenticity of sodium thiosulfate by dropping it with iodine. As a result of the chemical reaction, the latter must become discolored.
To verify the authenticity of sodium acetate, the substance is mixed with dry phenolphthalein and heated on a burner. As a result, sodium acetate will melt, phenolphthalein will turn red.

Sodium thiosulfate intravenously and alcohol

One of the most effective ways to get rid of alcohol dependence is the so-called conditioned reflex therapy (conditioned reflex therapy). Treatment is reduced to the fact that the patient is injected with drugs that, in combination with alcohol, cause a lot of unpleasant sensations: nausea, vomiting, hand tremors, coughing, heart rhythm disturbance, sweating, etc. As a result, a steady aversion to alcohol is formed.
However, most drugs that are used to treat alcoholism have contraindications, and their use is often accompanied by adverse reactions from the kidneys and the liver.
In comparison with such means, sodium thiosulfate is absolutely non-toxic. The only contraindication to his appointment is an individual intolerance.
The drug contributes to the formation of negative reflexes to alcoholic drinks from the nervous system and the gastrointestinal tract, but it does not do any harm to the body.
It usually takes 16 to 20 days to get rid of the addiction. Treatment is performed on an outpatient basis daily.
Sodium thiosulfate is administered intravenously, the dose is selected individually. Immediately after the completion of the procedure, the patient is given 20-30 g of vodka to monitor his reaction to drinking alcohol.
As a rule, the first unpleasant sensations arise after 2-3 days of treatment. Thus, a steady aversion to alcohol is gradually formed.
In 16-20 days after the start of the course, the number of injections is reduced to three times a week and then - gradually - to once a month.
Treatment with hyposulfite has no age limits. In this case, patients who have completed the full course of treatment, relapses are not observed. The drug is easily tolerated even by elderly people with various physical illnesses.

Application of the drug for weight loss

Proponents of cleansing the body at home with the help of sodium thiosulfate argue that the drug not only removes all the accumulated "dirt" from the body, but also helps remove excess kilograms.
Is it so? Most likely, it's not about the cleansing effect, but that the drug acts as an ordinary laxative when ingested. And the question of the advisability of using laxatives for weight loss is rather controversial.
Most doctors provide convincing evidence that it is impossible to solve the problem of excess weight in this way. But the result of self-treatment may well be dehydration, magnesium deficiency, chronic constipation, imbalance of water and electrolytes.
In general, to reduce weight, if possible, it is only thanks to a simple manipulation of the amount of water and the contents of the intestine. Remove fatty deposits Sodium thiosulfate is simply not capable.
Nevertheless, those who wish to lose weight with the help of the drug are still there. The solution is taken by diluting the contents of the ampoule in 200 ml of water. Half of the dose is drunk about an hour before breakfast, the remainder - an hour before dinner or a couple of hours after it, at night. The course usually lasts 10-12 days.
If you analyze the feedback on sodium thiosulfate, you can conclude that most of those taking it to lose weight, do not notice any significant changes in the body: many say that they managed to lose from 2 to 5 kg in a ten-day course.
Positive moments of cleansing are called sensation of lightness, which appears on day 4-6, as well as improvement of skin condition (some women say that their face was significantly cleansed of acne by the end of the course).

In pregnancy

In pregnancy, use is only possible in case of emergency. Studies of the effect of the drug on reproductive function in animals have not been conducted.
To date, it is not known whether sodium thiosulfate can provoke adverse embryonic effects when administered by pregnant women. It is also unknown whether the drug affects the ability to reproduce.

Reviews of Sodium Thiosulfate

Reviews of sodium thiosulfate in the IV testify to the high effectiveness of the drug for poisoning and in cases when it is used to treat alcohol dependence.
Good reviews on the forums leave and those who were forced to use the drug to treat psoriasis, allergic diseases and diseases of the female genital area.
In gynecology, sodium thiosulfate is used to treat endometriosis, endocrine infertility and a number of inflammatory diseases. In some cases, the drug is administered intravenously, in some - with the help of electrophoresis or in the form of microclysters.
On the Internet, you can also meet calls for the use of slimming and cleansing the body as a whole. However, the testimonies of those who took sodium thiosulfate indicate that such treatment methods do not give any particular results. The maximum that most patients can achieve is intestinal cleansing.