Nolicin tabs 400mg #20

Instruction for Nolicin

You can buy Nolicin on this page

Composition

In 1 tablet Nolicin contains 400 mg of norfloxacin. Auxiliary components: magnesium stearate, microcrystalline cellulose, povidone, purified water, anhydrous colloidal silicon dioxide.
The composition of the shell includes propylene glycol, yellow disperse dye E110, titanium dioxide, talc and gipromesole.

Form of issue

Medication Nolicin 400 mg is available in tablet form in blisters of 10, 20 pieces. Photo of the packaging can be seen at the beginning of the article.

pharmachologic effect

Many people ask: Is Nolicin an antibiotic or not? The active substance has an antimicrobial effect against staphylococci, klebsiel, enterobacteria, neisery, escherichia coli, chlamydia, legionella, salmonella, shigella and other infectious agents. The mechanism of action of the drug is based on the interaction of norfloxacin with DNA-gyrase (enzyme of the microorganism), which leads to destabilization of the DNA chain, and subsequent death of the microorganism. From this it can be concluded that Nolicin is an antibiotic, since it has a harmful effect on bacteria.
The antimicrobial effect can last up to 12 hours. Antibiotic Nolicin can be prescribed for diseases caused by mycobacteria, enterococci. Wikipedia contains a complete list of microorganisms sensitive to the action of the antibiotic.

Pharmacodynamics and pharmacokinetics

The active substance is absorbed quickly enough in the digestive system, peak concentrations in the blood are recorded after 1-2 hours after taking the medication. Biological availability of the drug reaches 30-40%. About 15% of the active substance binds to plasma proteins.
The drug is excreted through the renal system in an unchanged form, and only a small part is excreted through the digestive tract. Patients with severe pathology of the renal system have changed pharmacokinetic parameters.

Indications for use Nolicin (Spectrum of destination)

Nolicin tablets, what are they from? The drug is prescribed for the treatment of diseases of the genitourinary system of an infectious-inflammatory nature:
    chronically leaking prostatitis of bacterial origin;
    endometritis;
    cervicitis;
    cystitis;
    pyelonephritis;
    urethritis;
    uncomplicated form of gonorrhea.
From what else can be nominated Nolicin: bacterial gastroenteritis, shigellosis, salmonellosis. Additional indications for the use of tablets: prevention of traveler's diarrhea and prevention of septic complications in patients with neutropenia.

Contraindications (absolute and relative)

Abstract to the preparation contains the following absolute contraindications:
    intolerance to fluoroquinolones;
    bearing pregnancy;
    congenital deficiency of the enzyme glucose-6-phosphate dehydrogenase.
The drug is not used in pediatrics.

Relative contraindications:

    allergic responses to acetylsalicylic acid;
    epileptic syndrome;
    disturbances of cerebral blood supply;
    atherosclerotic changes in the vessels of the brain;

Side effects of Nolicin (Negative Effects)

From the genitourinary system:

    hypercreatininaemia;
    glomerulonephritis;
    polyuria;
    urethral bleeding;
    crystalluria;
    dysuria;
    albuminuria.

From the digestive tract:

    pseudomembranous enterocolitis;
    epigastric pain;
    impaired appetite;
    diarrheal syndrome;
    vomiting;
    nausea;
    bitter taste in the mouth;
    increase of ALT, AST.
Possible the development of hallucinations, headaches, arrhythmias, tachycardia, vasculitis, skin itching, fainting, insomnia, swelling, urticaria, exudative erythema with malignant course. Rarely registered candidiasis, a decrease in hematocrit, changes in blood counts, arthralgia, chemosis, phobia of light.

Instructions for use Nolicin (Method and dosage)

How to apply Nolicin correctly? Instructions for use recommend taking the medicine inside.
When infectious lesions of the genitourinary system: twice a day for 400 mg, the course is 7-10 days.
Treatment of uncomplicated cystitis is carried out for 3-7 days.
Chronic recurrent infectious diseases of the urinary tract are treated within 12 weeks.
How to take Nolicin with acute gastroenteritis of bacterial origin: twice a day for 400 mg for 5 days. With cervicitis, proctitis, urethritis and pharyngitis, 400 mg of norfloxacin is prescribed once.

Overdose

It is manifested by intense vomiting, nausea, dizziness, drowsiness, "cold" sweat. Therapy includes hydration treatment with forced diuresis, gastric lavage. Specific antidote is not developed.

Interaction

The drug reduces the effectiveness of nitrofurans, increases the concentration of cyclosporine (reciprocal action) and indirect anticoagulants. Norfloxacin reduces the overall clearance of theophylline by 1/4.
With simultaneous therapy with medications that reduce the epileptic threshold, epileptiform seizures may intensify. Antacids reduce the absorption of Nolicin. When taking antihypertensive drugs, a sharp drop in blood pressure is recorded. The use of medicines for general anesthesia requires mandatory control over heart rate, blood pressure figures, and cardiac function (ECG).

Storage conditions

In a dark place, protect from children. Temperature regime - up to 25 degrees Celsius.
Shelf life - 5 years.

special instructions

Before the appointment of an antibiotic, it is necessary to determine the sensitivity of the flora to norfloxacin. What is it for? Infectious agents may be sensitive to this drug, and the expected therapeutic effect will not be achieved at the right time.
In the case of pyelonephritis, Nolicin is recommended for use in combination with medicinal products of plant origin (eg, Kanefron). When treating norfloxacin, reviews with pyelonephritis are mostly positive. Monural is also used to treat diseases of the genitourinary system. The fact that it is better to appoint, can only be decided by the attending physician.

Children

In pediatrics it is not applied. Age restrictions - from 18 years.

With Alcohol (Adverse Reactions)

Alcohol and Nolicin do not combine. Ethanol-containing drinks have a negative effect on liver function and the general condition of the patient.

At pregnancy (early and late terms)

Nolicin can be prescribed only for vital indications in the II and III trimesters. In early terms, the drug is absolutely contraindicated.

Reviews about Nolicin (Opinion of doctors and patients)

Reviews for Nolicin with cystitis are exceptionally positive. The drug quickly enough to stop all the unpleasant symptoms of the disease (frequent urination, pain syndrome). Nolicin is an inexpensive and effective antibiotic for cystitis. Only the attending physician can prescribe the drug and explain how to take it with cystitis. The doctors' comments indicate that Nolicin is one of the drugs of choice in the treatment of diseases of the urinary system.