Ospamox powder for susp 250mg/5ml 6.6gr 60ml #1

Ospamox instruction

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Composition

The Ospamox capsules contain the active ingredient amoxicillin (250 mg).
The tablet contains an active ingredient amoxicillin (500 mg or 1000 mg). As auxiliary elements in the composition of the remedy include polyvidone, magnesium stearate, sodium starch glycolate, talc, MCC, titanium dioxide, methylhydroxypropyl cellulose.
In the Ospamox granules, the active ingredient amoxicillin (125 mg or 250 mg). As auxiliary substances in the composition contain sodium saccharin, simethicone, trisodium citrate anhydrous, guaran (gum), sodium benzoate, sucrose, flavor.

Form of issue

    Ospamox is manufactured in the form of Ospamox 1000 and Ospamox 500 tablets, which, respectively, contain 500 or 1000 mg of the active ingredient. In the package - 12 tablets.
    Granules that are used to make the suspension white or yellowish, have a berry smell, sweet with a bitter taste, taste. Packed in bottles of 60 ml of suspension.
    Ospamox capsules are also produced.

pharmachologic effect

The drug is an antibiotic that belongs to the group of penicillins, beta-lactam antimicrobial agents. Provides a wide range of antimicrobial effects.
The active ingredient amoxicillin is a subgroup of aminopenicillins. It produces a pronounced bactericidal effect, acts on a number of microorganisms, both gram-positive and gram-negative. Its mechanism of action is related to the ability of the active substance to inhibit the synthesis of peptidoglycan, which forms the basis of the bacterial cell membrane. The process of formation of peptidoglycan at the final stage is disrupted under the influence of amoxicillin because of inhibition of the enzymatic activity of penicillin-binding proteins. Since the structure of the cell membrane is disturbed during their reproduction and growth, the integrity of the cell membranes is disrupted and bacterial lysis is noted.
Amoxicillin does not have a toxic effect on the body, since mammals do not have peptidoglycan and penicillin-binding proteins, which the drug acts on.
Amoxicillin is an unprotected penicillin, it undergoes destruction under the influence of beta-lactamases. Therefore, those bacteria that produce penicillinase show resistance to Ospamox.
The drug is effective in the treatment of infectious diseases that have been provoked by those microorganisms that are sensitive to the effects of amoxicillin.
Sensitivities to the effect of the active substance do not show Citrobacter, Klebsiella, Proteus vulgaris, Bacteroides fragilis, Enterobacter, Serracia, Acinetobacter, Moraxella catarrhalis, Riketsia, Providencia, Chlamidia, Mycoplasma, Proteus, Pseudomonas.

Pharmacokinetics and pharmacodynamics

The active substance after ingestion is absorbed in the small intestine. Depending on the dose that was taken, the bioavailability level is 75 to 90%. The rate of absorption is not affected by eating. The highest concentration of the substance in the plasma is fixed 1-2 hours after ingestion. With plasma proteins binds to 17%.
In fluids and body tissues is distributed well. Passes through the placenta, enters the breast milk. High concentrations of the component in bile, pus, bronchial secretions are determined.
Through the blood-brain barrier penetrates poorly, but in people who suffer from meningitis, there is an increase in this indicator.
Part of Amoxicillin is metabolized, and penicillic acid, an inactive metabolite, is formed. It is mainly excreted through the kidneys, a small part - with bile. Half-life is 1-2 hours. In people with kidney disease, the elimination half-life increases to 5-20 hours.

Indications for use

Ospamox is indicated for use in the treatment of infectious diseases that have provoked microorganisms sensitive to amoxicillin:
    Diseases of respiratory organs and ENT organs of an infectious nature: abscess of the lungs, bronchitis acute and chronic, bacterial pneumonia, otitis, pharyngitis, sinusitis, the initial stage of whooping cough.
    Diseases of the urinary system of infectious origin: prostatitis, urethritis, cystitis, pyelonephritis; is prescribed to pregnant women for the treatment of asymptomatic bacteriuria.
    Diseases of the reproductive system of infectious origin: endometritis, septic abortion, uncomplicated gonorrhea.
    Diseases of soft tissues and skin of infectious origin: erysipelas, impetigo, infected dermatitis.
    Diseases of the gastrointestinal tract, bile ducts, liver of an infectious nature: cholecystitis (without cholestasis), paratyphoid, shigellosis, salmonella, typhoid fever.
    Other diseases: listeriosis, leptospirosis, infective endocarditis.
Also, the agent can be prescribed for the treatment of septicemia, bacterial meningitis, for the prevention of infections with small surgical interventions, if there is no need to take pricks of antibiotics.

Contraindications

Antibiotic can not be taken with such diseases and conditions:
    high sensitivity to the components of the drug, as well as to cephalosporins and beta-lactam antibiotics;
    children under 10 years (tablets);
    Infectious mononucleosis;
    epilepsy;
    acute lymphocytic leukemia;
    Gastrointestinal infections are severe, with diarrhea, vomiting;
    diathesis is allergic;
    bronchial asthma;
    respiratory viral infections;
    hay fever.
Caution means prescribe to people with meningitis and impaired renal function.

Side effects

Suspension Ospamox 250, tablets 500 mg and Ospamox 1000 mg, as a rule, patients are well tolerated. But sometimes in the course of treatment development of such negative effects was noted:
    Gastrointestinal tract: nausea, anorexia, vomiting, abdominal pain, flatulence, stools, dry mouth; change of taste, temporary staining of the tongue in a black shade, discoloration of the teeth - in isolated cases.
    CNS, peripheral UA: dizziness, hyperkinesia, fainting; people with kidney disease can show cramps.
    Liver and kidneys: a temporary change in the activity of hepatic transaminases, interstitial nephritis.
    Allergy: itching, rash, hives, exanthema, erythema multiforme, dermatitis; may develop Stevens-Johnson syndrome, anaphylactic shock, Quincke's edema, toxic epidermal necrolysis.
    Hemopoiesis: agranulocytosis, thrombocytopenia.
    Other manifestations: superinfection, fever, fungal infections of mucous membranes, in particular, candidiasis.
If side effects develop, you need to suspend treatment and contact a specialist.

Instructions for use Ospamox (Method and dosage)

Suspension Ospamox, instructions for use

How and how much time to take a child's Ospamox is determined by the attending physician. After the disappearance of the symptoms, the remedy should be taken for another 2-5 days.
To prepare a suspension, you should fill the vial with granules with water, shake, and then add water to the mark. Before giving the product to the child, the suspension for the children in the vial is shaken.
Patients under 1 year receive a suspension of 125 mg of 5 ml 2 times a day; children of 1-6 years of age receive a suspension of 250 mg of 5-7.5 ml 2 times a day; Children of 6-10 years are assigned a suspension of 250 mg to 7.5-10 ml 2 times a day.

Overdose

If Ospamox was taken in large doses, a person may develop nausea, stool, vomiting and, as a consequence, violations in the body of the water-salt balance. There is no specific antidote. In case of an overdose, the patient should be washed with a stomach, salt saline, enterosorbents. In case of violation of the water-salt balance, measures should be taken to restore the balance of electrolytes and water. The active component of Ospamox is excreted during hemodialysis.

Interaction

With the simultaneous use of phenylbutazone, probenecid, oxyphenbutazone, acetylsalicylic acid, sulfinpyrazone, the half-life of amoxicillin and its concentration in the blood increases.
When taking macrolides, tetracycline antibiotics, chloramphenicol, the bactericidal action of amoxicillin can be neutralized.
It is not recommended to take amoxicillin simultaneously with Allopurinol in order to avoid allergic reactions on the skin.
With simultaneous use, the absorption of Digoxin increases, therefore, it is necessary to adjust its dose.
Contraindicated taking simultaneously with disulfiram.
In the case of simultaneous administration of Ospamox with anticoagulants of the coumarin class, an increase in bleeding time is possible, therefore, a dose adjustment is necessary.
When taking both amoxicillin and methotrexate, the toxic effect of the latter increases. The renal clearance of Methotrexate decreases, therefore, it is necessary to control its concentration in the plasma.
Caution Ospomox should be combined with hormonal oral contraceptives, as their effectiveness with such a combination may be reduced. During the period of treatment it is recommended to use additional non-hormonal contraception.

Storage conditions

Keep the tablets and suspension at a temperature of up to 25 ° C. The prepared suspension should be applied within 14 days, it is stored in the refrigerator.

Shelf life

The Ospamox tablets are stored for 4 years, the pellets are 3 years old.

special instructions

Before starting treatment, a high sensitivity test for penicillins and cephalosporins should be performed.
People with severe allergic manifestations in history can develop severe reactions. It should be taken into account the possible need to eliminate the anaphylactic reaction.
People suffering from severe gastrointestinal disorders accompanied by vomiting and diarrhea should not take Ospomox orally, as the risk of absorption decreases.
It should be borne in mind that people suffering from kidney diseases are slowing the withdrawal of amoxicillin. In this case, you need to stop therapy or reduce the dose of the medicine.
With prolonged treatment, excessive reproduction of yeast fungi or resistant microorganisms may occur. There is a possibility of developing superinfection.
When treating large doses of Ospamox, you need to drink plenty of fluids for the prevention of crystalluria. In the presence of large concentrations of amoxicillin in the urine in the urinary catheter, precipitation may occur. It is important to check the catheter periodically.
When taking large doses, it is important to constantly monitor laboratory blood counts. In people with epilepsy or with kidney failure, large doses of the drug can cause seizures.
Suspension Ospamox in the composition contains citrate and sodium benzoate, it is important to take into account patients who observe a diet with sodium restriction.
Care must be taken when driving vehicles and working with dangerous appliances until an individual response to the drug is established.

Ospamox for children

Suspension Ospamox for children is prescribed, according to dosage, from birth. Children after 12 years of age are prescribed for treatment a medicine in the form of tablets and capsules.

In pregnancy and lactation

Since amoxicillin is able to penetrate the placenta, during pregnancy this remedy is prescribed only after comparing the probable benefit and harm.
In breast milk is determined in small amounts. There is a possibility that a child who is breastfed can develop high sensitivity reactions. Therefore, Ospamox can only be used with lactation after a careful comparison of the probable risk and benefit. If the child has had gastrointestinal disturbances, you should stop breastfeeding.

Reviews about Ospamox

Those reviews that users write indicate that Ospamox is effective in infectious diseases. Many parents nevertheless advise caution to use an agent to treat children, since the drug is an antibiotic.
There are also negative reviews, in which it is noted that the medicine provoked unpleasant side effects.