Zerkalin 10mg/ml 30ml

Zerkalin instruction manual

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Composition

Clindamycin hydrochloride 1.14 g in 100 ml.
Ethanol, propylene glycol, purified water, as auxiliary substances.

Form of issue

1% alcohol solution.

pharmachologic effect

Antimicrobial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The active ingredient of this drug, clindamycin, is an antibiotic that is active against strains of bacteria that cause acne. It suppresses the reproduction of Propionibacterium acnes, found in follicles and sebaceous glands. Clindamycin suppresses the synthesis of proteins of the microbial cell, interacting with the 50S subunits of the ribosomes. The anti-acne action is also explained by the reduction of free fatty acids on the skin.

Pharmacokinetics

Zerkalin accumulates and is long-term detected in comedones, where it shows its antibacterial activity. The minimum inhibitory concentration for Propionibacterium acnes is 0.4 μg / ml. And the average concentration of antibiotic in comedones after their treatment is much higher than this figure. At external application system absorption is insignificant, therefore extremely low concentration of active substance is defined in blood and urine.

Indications for use

Treatment of acne (acne).

Contraindications

    pseudomembranous colitis;
    increased sensitivity to clindamycin or other lincosamides;
    Crohn's disease;
    lactation period;
    simultaneous intake of muscle relaxants;
    age up to 12 years.

Side effects

A solution of Zerkalin in the place of application can cause irritation, redness, dry skin, burning, peeling. Possible increased secretion of skin secretion. At absorption there is a probability of occurrence of a diarrhea, a pain in a stomach and seldom enough develops pseudomembranous enterocolitis. Eye contact - a burning sensation in them.

Instructions for Zerkalin (Method and Dosage)

It is applied externally. The affected area must be cleaned and dried before applying the drug. Apply to the skin in the morning and evening. To obtain the effect, the treatment is continued for 1.5-2 months, if necessary - for 6 months.
Instructions for use contain a warning that you should avoid contact of the solution with acne with eyes and mouth. Wash hands well after use. If you accidentally contact the drug with these areas of the body, you need to rinse them abundantly with water.

Overdose

Overdose is unlikely, because with topical application of the drug absorption is minimal.

Interaction

The solution should not be used together with skin disinfectants and exfoliating agents and soaps containing abrasive substances, in view of the fact that it is possible to increase the irritating and drying effect.
Clindamycin and Erythromycin (Zinerit lotion, Isotrexin gel) are antagonists, therefore their simultaneous use is not recommended. With systemic action, the drug enhances the effect of muscle relaxants.

Terms of sale

Without recipe.

Storage conditions

At a temperature of not more than 250C.

Shelf life

2 years.

Reviews about Zerkalin

Those who used Zerkalin from acne, the reviews leave positive. When treated after a few days, the number of elements is reduced by 50%, redness and inflammation disappear. External therapy usually does not cause skin hypersensitivity and systemic side effects do not occur. All note that this drug is much more effective than the funds based on Tetracycline, for example, tetracycline ointment. The drug is called the "savior of the skin," they say that they "noticed a real effect" and that "Zerkalin coped with a problem that 5 years could not solve."
There are reviews about Zerkalin in the severe course of acne. It is noted that in this case, treatment only with local antibiotic use is not very effective and irrational - the drug has no effect on all links in the pathogenesis of acne. It is necessary to designate systemically acting antibiotics, retinoids and hormones. Also, with long-term local treatment, there is a risk of developing resistance of pathogenic flora.