Zineryt 30ml

Zineryt instruction

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Composition of Zineryt

The composition of Zineryt includes two bottles with a complex of preparations and a solvent, intended for further mixing.
The first vial of the drug complex includes 1200 mg of erythromycin and 360 mg of micronized zinc diacetate acetate, the active ingredients.
The second vial with the solvent includes 8.36 ml of diisopropyl sebacate and 21.6 ml of ethanol - additional constituents.
1 milliliter of the prepared lotion consists of 40 mg of erythromycin and 12 mg of micronized zinc dihydrate acetate, as well as 250 mg of diisopropyl sebacate and 550 mg of ethanol.

Form of issue

The company "Astellas Pharma" produces Zineryt in powder form with the attached solvent for further solution preparation. The complex package includes two 30 ml bottles (powder + solvent) and an applicator.

pharmachologic effect

Comedomolytic, antibacterial, anti-inflammatory.

Pharmacodynamics and pharmacokinetics

Zineryt is an erythromycin-zinc complex preparation, characterized by anti-acne performance, which is manifested by the combined effect of its active ingredients.
Effects of the antibiotic erythromycin are aimed at suppressing the replication of microorganisms (bacteriostatic action), causing acne (acne): epidermal streptococcus (Streptococcus epidermidis) and propionibacterium acne (Propionibacterium acne).
The activity of zinc is in its astringent action and decrease in secretion of the secretion of sebaceous glands (sebum).
The complex combination of all the ingredients of the preparation creates good conditions for their penetration into the skin. The main part of zinc binds to the follicular cells of the epithelium and does not penetrate into the systemic bloodstream. A small fraction of erythromycin undergoes systemic absorption and is subsequently excreted from the human body.

Indications for use

The drug Zineryt is designed to treat acne (acne).

Contraindications

Before using Zineryt, you should make sure that the patient has no personal hypersensitivity to erythromycin (other macrolides), zinc preparations or other ingredients of drugs, since these conditions are the only contraindications to his appointment.

Side effects

Sometimes during the treatment observed local negative phenomena, including skin irritation, a feeling of dryness or burning. In most cases, these events were mild and did not require the withdrawal of ongoing therapy and / or the appointment of symptomatic treatment.

Zineryt, instructions for use

To properly use Zineryt, you should mix the complex preparation and the solvent, which in order to extend the shelf life of the drug are in different vials. Before mixing both components of the future lotion, it is necessary to make sure that the expiration date of the preparation and the integrity of both bottles are consistent. Below are recommendations - how to make a home solution Zineryt from acne, suitable for further direct application.

Preparation of lotion:

    First of all, you need to unscrew the caps (caps) from both bottles and at the same time keep the cap from the vial with the drug complex;
    Pour the solvent into the vial of powder and tighten it tightly with the lid retained;
    immediately and thoroughly shake the mixture (for 60 seconds);
    remove the cap;
    remove the applicator from the protective packaging;
    insert the applicator into the neck of the vial with lotion and screw up the lid.
The solution prepared in this way is ready for use and can be stored at a temperature of 15-20 ° C for 5 weeks. To control the expiration date, you can write on the vial with the lotion the date of its manufacture.
Further instruction on the use of Zineryt assumes its exclusively external application. Unscrewing the lid from the bottle with the prepared lotion, you need to attach the applicator to the affected areas of the skin and apply the drug in a thin layer, lightly pressing on the base of the obliquely located bottle. To conduct the application should be on the previously cleaned skin areas with a frequency of 2 times in 24 hours (morning and evening). The speed of application depends on the pressure on the base of the bottle. The average single dose is 0.5 ml. The duration of the full course of treatment can reach 10-12 weeks.
Data on whether Zineryt helps with acne on a shorter period of its use are purely individual. In some cases, an improvement in the skin condition of the patient was observed after 14 days of application.

Overdose

Due to the characteristics of the external use of lotion, its overdose is unlikely. Some patients are probably using an excessive amount of the drug for the purpose of the quickest release of acne. It is not known whether such uneconomical consumption of a solution helps them to get rid of acne more quickly or simply leads to another purchase of the drug, but even in this case no complaints about any atypical negative manifestations have been reported.

Interaction

Until now, clinically important interactions of the complex of ingredients Zineryt with other drugs have not been identified.

Storage conditions

The temperature range of Zineryt storage should correspond to 15-25 ° C.

Shelf life

Closed bottles with the ingredients of the drug may persist for 3 years.
The prepared solution can be used for a maximum of 5 weeks.

special instructions

After applying the drug on the skin and its complete drying, the lotion becomes invisible.
With long-term use of Zineryt, it is theoretically possible to form cross-resistance in relation to other macrolides, Clindamycin and Linkomycin.
When carrying out applications, precautions should be taken to prevent application of the drug to the mucous membranes of the eyes, nose and mouth, to avoid the occurrence of irritation and / or burns.

Zineryt Analogues

Before replacing the drug with its analogue, you should consult a dermatologist who will help you choose an effective drug in each case.
Zineryt analogues can be produced in various dosage forms and can be ointments, creams, lotions, solutions or gels.
To date, Zineryt's analogues for their main purpose (treatment of acne) are represented by the following drugs:
    Dalacin;
    Clindovit;
    Zerkalin.

Children

All recommendations for the use of Zineryt, its dosage regimen and the duration of treatment for adult patients are similar for treatment of children.

Zineryt in pregnancy and lactation

The appointment of Zineryt in pregnancy and breast-feeding occurs according to the indications and with the recommended treatment regimen.

Reviews of Zineryt

Reviews of Zineryt in forums designed specifically to discuss methods, methods and drugs for combating acne, in terms of the effectiveness of this drug in most cases are positive. Patients noted a fairly rapid effect of the drug, especially compared to gels and ointments from acne of the previous generation, the absence of serious side effects, as well as the ease of using the lotion, thanks to the bottle with the applicator.
The most significant negative effect of Zineryt is the dryness of the skin after its application, and therefore people with initially dry skin this drug may not be suitable. Repeatedly raised the issue of the development of microorganisms resistance to the active ingredient of drugs - erythromycin, which can really develop in the case of continuous use of the drug. Also negative moments of Zineryt consider a short shelf life after the preparation of the solution (5 weeks) and its cost.
In general, reviews about Zineryt for acne give a positive evaluation of this drug, which allows you to recommend it for acne, of course, after consulting a dermatologist.