Dalacin vaginal supp 100mg #3

You can buy Dalacin vaginal supp on this page

Dalacin vaginal supp instruction for use

Composition

    In 1 capsule of the active substance, 150 mg or 300 mg.
    In 1 suppository, 100 mg.
    In 1 g of Dalacin vaginal cream 20 mg.

Form of issue

    Capsules.
    Solution for Injection Dalacin TS Phosphate.
    Suppositories are vaginal.
    Vaginal cream 2%.
    Dalacin Gel 1%.

pharmachologic effect

Antibacterial, anti-inflammatory.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The active ingredient clindamycin is an antibiotic of the lincosamide group. Depending on the dose, it has a bactericidal and bacteriostatic effect, disrupting protein exchange in the ribosome membrane of pathogenic microorganisms.
Gram-positive aerobic and anaerobic bacteria, actinomycetes, mycoplasmas, bacteroides are sensitive to it. It is effective in gynecological infections that cause Mycoplasmahominis, Mobiluncusspp., Gardnerellavaginalis.
The drug is resistant to Trichomonas vaginalis and Candida albicans.
All strains of Propioni bacteriumacnes are sensitive to clindamycin, which explains its effectiveness with acne vulgaris.

Pharmacokinetics

When ingested, a high (up to 90%) absorption is noted, which is not affected by food intake. The maximum concentration in the blood is determined after 50-60 minutes. It penetrates well into liquids and organs, high concentrations are noted in the bone tissue. Metabolized in the liver and excreted in the urine, in an insignificant amount with feces. T 1/2 2-4 hours, with renal dysfunction and in elderly people increases to 5 hours. No cumulation is observed with prolonged admission.
With the introduction of suppositories within 3 days, a 30% dose is absorbed into the bloodstream. Cmax in the blood is reached after 1-10 h, an average of 5 h.
When applying the cream for a week Cmax in the blood is determined after 4-24 hours. Systemic absorption - 5% of the administered dose. Systemic exposure to this route of administration is less pronounced than when administered or administered or administered. T 1/2 is 1.5-2.6 hours.
After application to the skin of the gel, the active substance is hydrolyzed in the ducts of the sebaceous glands and clindamycin is formed, which shows antibacterial activity. After external application in the content of comedones creates a sufficient concentration of the active substance, and in the blood and urine are determined inessential concentrations.

Indications for use

Suppositories Dalacin and vaginal cream: bacterial vaginitis.
Gel Dalacin T: treatment of acne, folliculitis, staphyloderma.
Capsules Dalacin C and solution:
    otitis, sinusitis, pneumonia, lung abscess, complicated bronchitis;
    furunculosis, acne, abscesses, erysipelas, osteomyelitis, infected wounds, purulent arthritis;
    endometritis, colpitis, salpingitis;
    abdominal abscesses, endocarditis, septicemia, peritonitis;
    periodontitis and periodontal abscess;
    malaria;
    prevention of endocarditis, infections in surgical interventions.

Contraindications

Taking the drug inside and parenterally is contraindicated when:
    antibiotic-associated colitis;
    hypersensitivity to lincosamides;
    age of up to 1 month;
    expressed violations of the liver and kidneys;
    pregnancy and lactation.
Contraindication for the use of cream and suppositories is the I trimester of pregnancy and lactation, for the application of the gel - the age of up to 12 years.

Side effects

Gel: dryness and irritation of the skin, contact dermatitis, folliculitis, increased production of sebum. Seldom manifest systemic effects - nausea, vomiting, diarrhea, possibly the development of colitis.
Cream: itching and swelling at the injection site, irritation of the mucosa, pain in the vagina, vaginal candidiasis, trichomonas vaginitis, cycle disorders, bleeding. Systemic side effects can be manifested by headache, dizziness, dysuria, abdominal pain, swelling, diarrhea or constipation, nausea, fungal and bacterial infections, allergic reactions (rash, itching, urticaria).
Capsules and solution for injection:
    pain in the stomach, nausea, loose stool, esophagitis, ulcer of the esophagus;
    eosinophilia, leukopenia, agranulocytosis, thrombocytopenia;
    urticaria, rash, itching, epidermal necrolysis;
    anaphylactic shock (with rapid administration) and anaphylactoid reactions;
    with rapid intravenous administration of the drug - weakness, dizziness, hypertension;
    when intramuscular - redness and abscesses at the injection site.

Instruction on Dalacin (Method and Dosage)

Dalacin suppositories, instructions for use

Candles are administered intravaginally before bedtime for one 3 consecutive days. They can be administered without the applicator: in the supine position on the back with the knees pulled up by the middle finger of the hand, the candle is inserted as deep as possible.
A plastic applicator facilitates the administration of a suppository. The flat end of the suppository is placed in the opening of the applicator. Holding the applicator horizontally, inject it deeply into the vagina. Pressing the plunger, introduce a suppository. The applicator can be used several times, washing it with warm water and soap.
The gel is applied a thin layer only on the affected parts of the skin 2 times a day. Treatment continues for 6-8 weeks, sometimes up to 6 months. After application within several months, the effectiveness of the drug may decrease, in such cases a break for a month is made.

Overdose

Cases of overdose when ingestion of recommended doses are not noted. When anaphylactic reactions occur, glucocorticosteroids and antihistamines are administered. Antidote does not exist. Hemodialysis is ineffective.
There are also no reports of an overdose of intravaginal cream and candles. Perhaps the manifestation of systemic reactions: diarrhea, including hemorrhagic, pseudomembranous colitis. Conduct symptomatic therapy.

Interaction

Strengthens the action of muscle relaxants, as it violates neuromuscular transmission, there is a cross-reaction with lincomycin.
It inhibits the activity of aminoglycosides, macrolides and chloramphenicol. The drug in capsules is not prescribed together with Erythromycin, Ampicillinum, Calcium Gluconate, barbiturates, Magnesium sulfate, Aminophylline.
When administered with opioids, the depressant effect on breathing is enhanced.
Cream and candles are not recommended to be used simultaneously with other drugs for intravaginal administration.
Components of the cream reduce the strength of condoms, so they are not recommended for use with vaginal cream.

Storage conditions

At a temperature of no more than 25 ° C.

Shelf life

Gel, cream, solution for injection: 2 years.
Candles: 3 years.
Capsules: 5 years.