Atorvastatin tabs 40mg #30
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Atorvastatin user manualReed more and buy Atorvastatin on this pageTo buy other dosage just contact usCompositionOne tablet contains 21.70 or 10.85 milligrams of atorvastatin calcium trihydrate, which corresponds to 20 or 10 milli..
Atorvastatin user manual
Reed more and buy Atorvastatin on this page
To buy other dosage just contact us
One tablet contains 21.70 or 10.85 milligrams of atorvastatin calcium trihydrate, which corresponds to 20 or 10 milligrams of atorvastatin.
As ancillary components there are opedrai II, magnesium stearate, aerosil, starch 1500, lactose, microcrystalline cellulose, calcium carbonate.
Form of issue
Produced in the form of biconvex tablets, covered with a white membrane of the film.
This drug is hypocholesterolemic - competitively and selectively inhibits the enzyme, which regulates the rate of conversion of HMG-CoA to mevalonate, which later passes into sterols, including cholesterol.
The decrease in the number of lipoproteins and cholesterol in plasma after taking the drug is due to a decrease in the synthesis of cholesterol in the liver and the activity of HMG-CoA reductase, as well as an increase in the level of LDL receptors on the surface of the hepatic cells, thereby increasing the uptake and catabolism of LDL.
In people with homozygous and heterozygous familial hypercholesterolemia, mixed dyslipidemia and non-hereditary hypercholesterolemia, a decrease in apolipoprotein B, total cholesterol and low-density cholesterol-lipoproteins is observed with this medication.
This drug reduces the possibility of developing ischemia and mortality in people of all ages who have myocardial infarction without unstable angina and Q wave. It also reduces the incidence of nonfatal and fatal stroke, the overall incidence of cardiovascular diseases and the risk of fatal cardiovascular disease.
Pharmacodynamics and pharmacokinetics
Has a high absorption, the highest concentration in the blood is observed after a lapse of one to two hours after ingestion. Bioavailability is low due to presystemic clearance of the active substance in the gastric mucosa and the effect of "first passage through the liver" - is 12 percent. Approximately 98 percent of the dose is associated with plasma proteins. Metabolization occurs in the liver with the formation of active metabolites and inactive substances. The half-life is 14 hours. During hemodialysis is not indicated.
Indications for use atorvastatin
What causes atorvastatin tablets? Indications for the use of atorvastatin are as follows:
to reduce the amount of cholesterol and cholesterol / LDL in people with homozygous familial hypercholesterolemia, when non-pharmacological methods and diet therapy do not give the proper effect;
for treatment in combination with a diet of people with elevated triglycerides in the serum and people with disbetalipoproteinemia, when diet therapy does not help;
together with a diet to reduce the elevated levels of total cholesterol, triglycerides and apolipoprotein B and increase the amount of HDL cholesterol in people with combined hyperlipidemia, heterozygous non-family and familial hypercholesterolemia, primary hypercholesterolemia.
The medicine can not be taken at:
the age of 18 years;
pregnancy and the period of breastfeeding;
active liver diseases or increased activity of "liver" enzymes for unclear reasons;
hypersensitivity to the contents of the drug.
It should be taken with caution in diseases of skeletal muscles, trauma, extensive surgical interventions, uncontrolled epilepsy, sepsis, arterial hypotension, metabolic and endocrine disruptions, electrolyte balance disorders of high severity, hepatic diseases in history and alcohol abuse.
When these tablets are taken, the following can be observed:
exacerbation of gout, mastodynia, weight gain (very rare);
albuminuria, hypoglycemia, hyperglycemia (very rarely);
petechiae, ecchymosis, seborrhea, eczema, increased sweating, xerodermia, alopecia;
Lyell's syndrome, multiforme exudative erythema, photosensitivity, facial edema, angioedema, urticaria, contact dermatitis, skin rash and itching (rarely);
impaired ejaculation, impotence, decreased libido, epididymitis, metrorrhagia, nephrourolythiasis, vaginal bleeding, hematuria, nephritis, dysuria;
joint contractures, muscular hypertonia, torticollis, rhabdomyolysis, myalgia, arthralgia, myopathy, mozitis, tendosynovitis, bursitis, muscle cramps, arthritis;
tenaemia, bleeding gums, melena, rectal bleeding, impaired liver function, cholestatic jaundice, pancreatitis, duodenal ulcer, cheilitis, biliary colic, hepatitis, gastroenteritis, ulcers of the oral mucosa, glossitis, esophagitis, stomatitis, vomiting, dysphagia, eructation, sensation dryness in the mouth, increased or decreased appetite, abdominal pain, gastralgia, flatulence, diarrhea or constipation, heartburn, nausea;
nosebleeds, exacerbation of bronchial asthma, dyspnea, pneumonia, rhinitis, bronchitis;
thrombocytopenia, lymphadenopathy, anemia;
angina pectoris, arrhythmia, phlebitis, increased blood pressure, orthostatic hypotension, palpitations, chest pains;
loss of taste sensations, parosmia, glaucoma, deafness, bleeding in the retina, disruption of accommodation, dry conjunctiva, ringing in the ears, amblyopia;
loss of consciousness, hypoesthesia, depression, migraine, hyperkinesia, facial nerve paralysis, ataxia, emotional lability, amnesia, peripheral neuropathy, paresthesia, nightmares, drowsiness, malaise, asthenia, headache, dizziness, insomnia.
Atorvastatin, instructions for use (Method and dosage)
According to the instructions for use of Atorvastatin, the drug is taken during meals or regardless of meals at any time of the day. The dose is selected depending on the initial level of cholesterol / LDL, the individual effect and the purpose of treatment. Before starting the use of the drug, a standard lipid-lowering diet is recommended, which must be followed throughout the treatment period.
The initial dose is 10 milligrams once a day, then it can go up to a maximum of 80 milligrams once a day. With homozygous familial hypercholesterolemia, 80 milligrams are prescribed once a day. With renal failure and other kidney diseases, the dose does not need to be adjusted. In case of liver failure, the dose should be reduced.
In case of an overdose, rhabdomyolysis and liver dysfunction may develop. In such cases, it is necessary to wash the stomach, then take enterosorbent drugs. If necessary, you can conduct symptomatic treatment.
Simultaneous reception with protease inhibitors increases the concentration of the active substance in the blood plasma. Simultaneous reception with drugs that reduce the concentration of endogenous steroid hormones (including spironolactone, ketoconazole and cimetidine) increases the possibility of reducing endogenous steroid hormones.
With simultaneous administration with nicotinic acid, erythromycin, fibrates and cyclosporins increases the possibility of myopathy in treatment with other drugs of this class.
Terms of sale
You don't need a prescription to buy Atorvastatin online.
Store in a dry and dark place. The air temperature should not exceed 25 degrees.
Shelf life - three years.
Reviews about Atorvastatin
Reviews about Atorvastatin in the forums indicate a high effectiveness of the drug, but it is worth considering that the drug can not be combined with many other substances.