Bisoprolol Cor tabs 2.5mg #30

User manual for Bisoprolol Cor

Reed more and buy Bisoprolol Cor tablets on this page

Composition

The composition of one tablet Bisoprolol Cor includes hemifumarate and bisoprolol fumarate in a quantitative ratio of 2: 1.
Excipients: colloidal silica, corn starch, MCC, crospovidone, magnesium stearate, calcium hydrogen phosphate.
Sheath composition: Macrogol 400, hypromellose, dimethicone 100, titanium oxide.

Form of issue

Bisoprolol Cor - tablets covered with a white membrane, biconvex, cordate, with a notch from both ends.
Existing forms of release: 10 tablets in a blister, 3 blisters in a paper bundle; 14 or 30 tablets in a blister, 1 blister in a paper bundle; 25 tablets in a blister, 1 blister in a paper bundle.

pharmachologic effect

Has hypotensive, antiarrhythmic, anti-anginal action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Bisoprolol is an selective beta-blocker that does not have sympathomimetic activity and membrane-stabilizing action.
Reduces: the content of renin in the blood, the need of the heart in oxygen, the number of heartbeats. It blocks low-dose β1-adrenoreceptors, reduces catecholamines activation of cAMP synthesis from ATP, lowers the intracellular transit of calcium ions, inhibits conduction and excitability, inhibits AV conduction. When the dose is increased, the β2-adrenoblocking effect exerts.
The total peripheral resistance in the first day slightly increases, and after another 1-3 days comes to the original value, and with a long-term appointment decreases.
The decrease in pressure is caused by a sympathetic effect on the peripheral vessels, a decrease in the minute blood volume, inhibition of the work of the renin-angiotensin system. With arterial hypertension, the effect appears after 2-5 days.
Antianginal action is caused by a decrease in the need for the heart in oxygen as a result of a decrease in the number of cardiac contractions per unit time and contractility, lengthening diastole.
Antiarrhythmic action is associated with the elimination of tachycardia, arterial hypertension, increased activity of the sympathetic system, increased cAMP content, inhibition of AV conduction.

Pharmacokinetics

Bioavailability - 85-90%; food intake does not affect it. Bisoprolol is adsorbed from the intestine by 90%. The maximum content in the blood comes in 3 hours. Binding to blood proteins - up to 35%.
It undergoes transformations along the oxidative path. The main derivatives are not pharmacologically active. It is excreted by the kidneys.

Indications for use Bisoprolol Cor

Indications for use of the drug are quite limited. Persons of the older age group often suffer from cardiac failure according to the chronic type, from which the Bisoprolol Cor in the treatment of this pathology.

Contraindications

    Hypersensitivity to bisoprolol or other constituents of the drug.
    AV blockade.
    Acute and chronic (decompensated) heart failure.
    Hypotension arterial.
    Syndrome of weakness of the sinus node.
    Bradycardia.
    Sinoatrial blockade.
    Bronchial asthma or COPD.
    Cardiogenic shock.
    Violations of the arterial link of peripheral circulation.
    Pheochromocytoma.
    Age to 18 years.
    Metabolic acidosis.

Side effects

        Common disorders: asthenia, fatigue.
        From the nervous system: syncopal conditions, dizziness.
        Mental disorders: depression, hallucinations, insomnia.
        From the sense of sight: conjunctivitis, hearing impairment.
        On the part of the circulatory system: a decrease in pressure, a violation of AV-conduction, a decrease in the pulse, orthostatic hypotension.
        On the part of the respiratory system: bronchospasm, allergic rhinitis.
        From the muscular apparatus: convulsions.
        On the part of the digestive system: vomiting, nausea, diarrhea, hepatitis.
        On the part of the reproductive system: the deterioration of potency.
        From the skin: itching, rash, redness, alopecia.
        Laboratory indicators: increases in triglycerides, AST and ALT

Instructions for use Bisoprolol Cor (Method and Dosage)

Instructions on the medicine recommends taking the pill in the morning, orally, with water. Do not chew, do not grind.
Therapy of a chronic type of heart failure by means of Bisoprolol Cor requires titration and constant medical control. When titrating, the dose can be increased only when the previous dose is tolerated satisfactorily.
The maximum dose for the therapy of heart failure according to the chronic type is bisoprolol in an amount of 10 mg once a day.
At the beginning of the treatment, when taking half the Bisoprolol Cor in the patient, it is necessary to observe the first 4 hours, monitoring the pulse, pressure, and conductivity.

Overdose

Symptoms: bronchospasm, AV blockade, bradycardia, hypoglycemia, excessive pressure decrease, acute heart failure.
Overdose therapy: discontinuation of the drug and symptomatic therapy.

Interaction

Iodine-containing radiopaque agents and allergens for immunotherapy increase the risk of systemic allergic reactions in persons receiving bisoprolol.
Phenytoin, agents for inhalation anesthesia increase the cardiodepressive and hypotensive effect of bisoprolol.
Nonsteroidal anti-inflammatory drugs, glucocorticosteroids and estrogens suppress the hypotensive effect of Bisoprolol Cor.
Cardiac glycosides, guanfacine, verapamil, reserpine, methyldopa, diltiazem and antiarrhythmics increase the risk of AV blockade, bradycardia and cardiac arrest.
Nifedipine, diuretics, sympatholytics, clonidine, hydralazine lead to a strong decrease in pressure.
Tetracyclic and tricyclic antidepressants, neuroleptics, ethanol, sedatives can increase the inhibition of the nervous system.
Ergotamine increases the risk of peripheral blood flow disorders.

Terms of sale

To buy Bisoprolol Cor you don't need a prescription.

Storage conditions

    At temperatures below 25 ° C.
    Keep away from children.
Shelf life - three years.

special instructions

The drug does not change the ability to drive.

Alcohol and Bisoprolol Cor

Bisoprolol Cor and alcohol - not recommended combination, as there is an increase in the negative effects of ethyl alcohol.

During pregnancy (and lactation)

During lactation or pregnancy, the drug can be used with great care, carefully considering all the risks.

Reviews of Bisoprolol Cor

Comments of doctors on Bisoprolol Cor and medi-oriented forums positively evaluate the therapeutic effects of the drug, including in a delayed period of time.