Nitromint 0.4mg/dose 10gr 180doses

Instruction for Nitromint

You can buy Nitromint without prescription

Composition

1 dose - nitroglycerin in the form of a solution of 0.04 g.
Ethanol (96%), propylene glycol, - as auxiliary substances.

Form of issue

Dosed aerosol in a balloon with a single dose of 0.4 mg. In a cylinder equipped with a dispenser-sprayer, 10 g of solution, which corresponds to 180 doses. Does not contain freon.

pharmachologic effect

Vasodilating, antianginal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Nitroglycerin is a nitrogen-containing compound, a peripheral vasodilator with venodilating and antianginal action.
The action of nitroglycerin is associated with the ability to release nitric oxide, which affects the endothelium, causing smooth muscle relaxation and vasodilation. As a result, preload (venous return) and postload (resistance of large vessels) decrease. The load on the heart decreases, the need for oxygen is reduced.
Simultaneous expansion of the coronary vessels significantly increases the delivery of oxygen to the heart muscle. Reduction of venous return leads to a decrease in pressure in the small circle, a decrease in the volume of the left ventricle and eliminates pulmonary edema.
Relaxes smooth muscles of the gallbladder and ducts, bronchi, urinary tract, intestines. The drug begins in 30-60 seconds and lasts from 10 to 30 minutes.

Pharmacokinetics

Aerosol is rapidly absorbed from the oral cavity. Bioavailability of 100%. Cmax in the blood is determined after 4 minutes. 60% contact with blood proteins. It is associated with red blood cells.
Metabolized with the formation of mononitrates and dinitrates. Metabolites are excreted by the kidneys. T1 / 2 is 2.5-4.5 minutes.

Indications for use

    angina (relief and prevention of seizures);
    acute left ventricular failure (ancillary treatment).

Contraindications

    shock;
    collaptoid states;
    hypersensitivity to nitrates;
    age to 18 years.
With caution is prescribed with orthostatic hypotension, acute circulatory insufficiency with blood pressure below 90 mm Hg. hypertrophic cardiomyopathy, hemorrhagic stroke, severe renal and hepatic insufficiency, anemia, epilepsy, acute myocardial infarction with low degree of filling of the left ventricle, thyrotoxicosis, alcoholism, TBI, angle-closure glaucoma, migraine.

Side effects

Aerosol Nitromint can cause:
    headache, tachycardia, lowering blood pressure, dizziness, heat, cyanosotostatic collapse;
    weakness, inhibition, a sense of anxiety;
    dry mouth, nausea, abdominal pain;
    itching, skin rash;
    burning under the tongue, redness of the mucosa in the place of application;
    blurred vision;
    methemoglobinemia.

Instructions for use Nitromint (Method and dosage)

The drug is sprayed under the tongue in time to delay breathing. Before the first use, the pump must be filled by pressing the valve until the aerosol appears. If the balloon is not often used, the pump must be refilled.
The balloon is sprayed vertically, head up. One pressure on the valve corresponds to 1 dose - 0.4 mg nitroglycerin. Before use, shake the balloon is not necessary.

Aerosol Nitromint, instructions for use

With an attack of angina, the spray is sprayed in an amount of 1-2 doses (0.4-0.8 mg) in the sitting position, at intervals of 30 s. Then you need to close your mouth. Repeated administration - up to 3 doses in 15 minutes.
To prevent an attack, 1 dose is used 10 minutes before the load.
With pulmonary edema and left ventricular failure, 4 doses and more are administered in a short time, controlling blood pressure (systolic> 100 mm Hg).
In elderly people, the dosing regimen does not change.

Overdose

Overdose is manifested by symptoms: orthostatic hypotension, headache, a sharp decrease in blood pressure, tachycardia, dizziness, vomiting, drowsiness, redness of the face, a feeling of heat.
When taking high doses (20 mg / kg and more), methaemoglobinaemia, dyspnoea, cyanosis, collapse develops. Treatment: to lay the patient, giving legs an elevated position. In severe cases - the introduction of norepinephrine, replenishment of BCC. Epinephrine is contraindicated.

Interaction

Vasodilators, ACE inhibitors, beta-adrenoblockers, CCB, neuroleptics, antidepressants, MAO inhibitors, procainamide and phosphodiesterase inhibitors increase the antihypertensive effect of the drug.
Simultaneous reception of ATSTS, ethanol enhances the vasodilating effect.
Nitromint enhances the action of the antiadrenergic agent Dihydroergotamine and reduces the effects of Heparin.

Terms of sale

To buy online Nitromint you don't need a prescription.

Storage conditions

At a temperature of 15 to 25 ° C.
Shelf life - 3 years.

Reviews

Nitroglycerin in the form of tablets in a critical situation may not give the desired effect. When compared with sublingual tablets, the use of aerosol is more effective - the onset of action is accelerated, the antianginal effect is more pronounced and the duration of the attack of angina is shortened. In this connection, the drug in this release is suitable for the provision of "first aid". A number of patients prefer aerosol form because of the convenience of its use.
There are negative reviews, which are associated with the presence of adverse reactions. Spray Nitromint, like all nitrates, causes a headache of pulsating nature and lasting from 15 minutes to several hours in individual patients. In elderly patients, it is accompanied by dizziness. The appearance of a headache is noted after the first administration of the drug. More often it is noted with the use of long-acting drugs.
To reduce this side effect, it is recommended to use drugs with menthol (for example, Validol) or NSAIDs (Acetylsalicylic acid, Paracetamol) together. Much less common are side effects such as heartburn, nausea, and vomiting.