Riboxin solution 20mg/ml 5ml #10
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Riboxin solution instruction for useReed more and buy Riboxin solution on this pageCompositionActive ingredient: inosine (riboxin) 20 mg;Excipients: propylene glycol, sodium hydroxide, sodium sulfite anhydrous, water for injection..
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Riboxin solution instruction for use
Reed more and buy Riboxin solution on this page
Composition
Active ingredient: inosine (riboxin) 20 mg;
Excipients: propylene glycol, sodium hydroxide, sodium sulfite anhydrous, water for injection.
Packaging
In ampoules of 5 or 10 ml, 5 or 10 pieces per pack.
pharmachologic effect
Riboxin solution is a derivative (nucleoside) of purine - the precursor of ATP adenosine triphosphate. It belongs to the group of drugs that stimulate metabolic processes. It has antihypoxic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, prevents the effects of intraoperative renal ischemia. He is directly involved in glucose metabolism and contributes to the activation of metabolism in hypoxic conditions and in the absence of ATP.
It activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration, and also contributes to the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle. Penetrating into the cells, it has a positive effect on metabolic processes in the myocardium - it increases the strength of the heart contractions and contributes to a more complete relaxation of the myocardium in diastole, as a result of which the stroke volume increases. The mechanism of antiarrhythmic action is not completely clear.
Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and gastrointestinal mucosa).
Pharmacokinetics
Metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. In small quantities excreted in the urine.
Riboxin injection, indications for use
Riboxin solution is prescribed to adults in the treatment of ischemic heart disease, myocardial dystrophy, after myocardial infarction, and cardiac arrhythmias caused by the use of cardiac glycosides.
Prescribed for hepatitis, cirrhosis, fatty liver caused by alcohol or drugs, and urokoproporfirii.
As a means of pharmacological protection of the kidneys from ischemia during a temporary shutdown of the kidney from blood circulation.
The drug improves the visual function of open-angle glaucoma with normalized under the influence of antihypertensive therapy intraocular pressure.
Contraindications
Hypersensitivity to the drug, gout, hyperuricemia, pregnancy, lactation, age up to 18 years (efficacy and safety have not been established). Use with caution in renal failure.
Dosage and administration
The drug is administered intravenously in a stream slowly or drip (40-60 drops in 1 minute). Treatment begins with the introduction of 200 mg (10 ml of 2% solution) 1 time per day, then, with good endurance, the dose is increased to 400 mg (20 ml of 2% solution) 1-2 times a day.
Duration of treatment is 10-15 days.
Jet injection of the drug is possible with acute arrhythmias in a single dose of 200-400 mg.
For pharmacological protection of ischemic kidneys, Riboxin solution is administered intravenously in a single dose, 1.2 g (60 ml of a 2% solution) 5-15 minutes before clamping the renal artery, and then another 0.8 g (40 ml of a 2% solution ) immediately after the restoration of blood circulation.
When drip into a vein, a 2% solution of the drug is diluted in 5% dextrose solution (glucose) or an isotonic solution of sodium chloride (up to 250 ml).
Side effects
Allergic reactions: pruritus, skin flushing (the drug should be discontinued). Rarely: an increase in the concentration of uric acid in the blood, exacerbation of gout (with prolonged use).
special instructions
Riboxin solution is not used for emergency correction of disorders of the heart.
Interaction
When used as part of complex therapy, Riboxin solution contributes to increasing the effectiveness of antiarrhythmic, antianginal and inotropic drugs.
Overdose
Currently, overdose cases have not been reported.
Storage conditions
Shelf life - 3 years.
In a dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
Termf of sell
You don't need a prescription to buy Riboxin solution.