Torvacard tabs 20mg #28

User manual for Torvacard

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Composition

One tablet contains 40, 20 mg or 10 mg of atorvastatin.
Additional substances: sodium croccarmellose, magnesium stearate, microcrystalline cellulose, magnesium oxide, hydroxypropyl cellulose, silicon dioxide, lactose monohydrate.
The shell consists of macrogol, hypromellose, titanium dioxide and talc.

Form of issue

Tablets in a shell of white color, 10 pieces each. in blisters.

pharmachologic effect

It belongs to the group of statins and has a hypolipidemic effect. Inhibits selectively and competently the enzyme involved in the synthesis of cholesterol.
Triglycerides and cholesterol become constituent parts of atherogenic lipoproteins in the liver, after which they are transferred to the periphery by blood. By interacting with low-density lipoprotein receptors, they are converted into these lipoproteins.
Due to the inhibition of HMG-CoA reductase, the level of lipoproteins and cholesterol in the blood decreases. The synthesis of LDL is reduced and the activity of their receptors is increased.
The drug is able to reduce the amount of LDL in homozygous hypercholesterolemia of a hereditary nature, when other drugs have no effect.
The drug reduces the level of cholesterol by 30-46%, atherogenic lipoproteins by 41-61%, triglycerides by 14-33% and increases the content of lipoproteins that have anti-atherogenic properties.

Pharmacodynamics and pharmacokinetics

In the blood, the maximum concentration of the drug occurs within 60-120 minutes. Eating reduces the duration of absorption, but lowering cholesterol is comparable to that without eating. In case of application in the evening, the concentration of the drug is lower than when taken in the morning.
With blood proteins binds to 98%. It is metabolized in the liver with the formation of active metabolites.
It is excreted with bile, the half-life is 14 hours. The effectiveness of the drug is maintained by active metabolites up to 30 hours. When hemodialysis is not withdrawn.

Indications for the use of Torvacard

Torvacard tablets - what are they from?
The drug is used in conjunction with a diet for:
    reduction of cholesterol, atherogenic lipoproteins, triglycerides, apolipoprotein B, and an increase in the amount of HDL in hypercholesterolemia, heterozygous and combined hypercholesterolemia (types IIa and IIb according to Fredrickson);
    treatment of patients who have increased triglycerides in the blood (Fredrickson type IV) and type III Fredrickson (dysetalipoproteinemia), if the diet does not work;
    decrease in the amount of cholesterol and LDL with homozygous family-type hypercholesterolemia;
    treatment of heart disease and blood vessels in the presence of increased factors for the onset of coronary heart disease (arterial hypertension, patients older than 55 years, a history of stroke, albuminuria, left ventricular hypertrophy, smoking, peripheral vascular disease, IHD in the family, diabetes mellitus).
The most frequent indications for the use of Torvacard are secondary prevention of myocardial infarction, death, revascularization, stroke on the background of dyslipidemia.

Contraindications

    severe liver damage;
    elevated levels of transaminases in the blood;
    hereditary intolerance to glucose and lactose, lactase deficiency;
    women of reproductive age who do not use contraception;
    pregnancy and lactation;
    children under 18;
    individual intolerance.
Cautiously used for metabolic and metabolic disorders, arterial hypertension, alcoholism, liver diseases, sepsis, changes in water-electrolyte balance, diabetes mellitus, epilepsy, injuries and major surgeries.

Side effects

Nervous system: insomnia, headache, depression, sleep disorders, paresthesia, ataxia, neuropathy.
The digestive tract: stomach pain, indigestion, nausea and vomiting, stool disorders, changes in appetite, pancreatitis and hepatitis, jaundice.
Musculoskeletal system: pains in the joints and muscles, in the back, cramps in the muscles of the legs, myositis.
Allergic manifestations: hives, itching, anaphylactic shock, erythema multiforme, angioedema, Lyell's syndrome.
Violations in laboratory indicators: changes in the level of glucose, increased activity of liver enzymes and creatine phosphokinase in the blood.
Other manifestations may be edemas of peripheral tissues, pain in the chest, tinnitus, baldness, weakness, weight gain, impotence, secondary renal insufficiency, and a decrease in the number of platelets.
Tablets from cholesterol in some cases led to depression, violations of sexual function, rare cases of involvement of the connective tissue of the lungs, diabetes mellitus (development depends on risk factors - fasting glucose, arterial hypertension, body mass index, hypertriglyceridemia).

Instructions for use of Torvacard (Method and dosage)

Please reed this instruction before buy Torvacard.
In the process of treatment the patient must observe a lipid-lowering diet.
Therapy is started with 10 mg per day, subsequently increased to 20 mg. Daily therapeutic dose - from 10 to 80 mg. The dose is selected taking into account laboratory indicators and individual characteristics.
The drug is taken regardless of food.
Before the reception and, if necessary, dose adjustments, laboratory control of lipid levels is performed.
The effect of the application comes after 14 days.
To treat patients with homozygous hypercholesterolemia, one of the few drugs that give effect is Torvacard, the instructions for use clearly determine the daily dose, which is 80 mg.

Overdose

When symptoms of an overdose occur symptomatic therapy.

Interaction

Use of drugs that inhibit metabolism, mediated by the enzyme CYP450, erythromycin, antifungal and immunosuppressive drugs, fibrates, cyclosporine, clarithromycin, nicotinamide, nicotinic acid, the concentration of Torvacard in the blood increases. This increases the likelihood of myopathy, so you need to monitor the level of CK in the blood.
The joint administration of funds with aluminum hydroxide or magnesium reduces the concentration of Torvacard, but this does not affect the effectiveness.
Combination with colestipol reduces the concentration of atorvastatin, but their combined lipid-lowering effect is superior to each separately.
Cimetidine, Spironolactone, ketoconazole increases the probability of a decrease in the level of steroid hormones.
Taking oral contraceptives and a daily dose of Torvacard 80 mg increases the content of ethinyl estradiol in the blood.
Use in combination with digoxin reduces the concentration of the latter by 20%.

Storage conditions

In a place that is protected from children.
Shelf life - 4 years.

special instructions

Before starting treatment, you should try to lower cholesterol level by diet, treatment of obesity and concomitant diseases, increase in physical activity.
In the process of treatment, it is necessary to control the level of AST and ALT. For the first time the control is performed before, 6 weeks and 3 months after the start of therapy, as well as after dose adjustment and once every six months. If the level of enzymes increases more than 3 times, the drug is canceled.
Taking Torvacard can cause weakness and pain in the muscles (myopathy) and increase in CK in the blood. If muscle pain or weakness occurs in combination with fever, you should consult your doctor.
The drug is canceled at the risk of renal failure due to rhabdomyolysis. This can be trauma, extensive surgery, metabolic and electrolyte balance disorders, arterial hypotension, severe infection, convulsions.
Taking Torvacard can lead to the development of diabetes in patients who have an increased risk. But it is worth remembering that the benefits of taking statins are higher than the risk of diabetes, so there is no need to cancel the drug, and patients at risk should be constantly under the supervision of a doctor.

Children

Contraindicated up to 18 years.

In pregnancy and lactation

Contraindicated because of the high risk of fetal pathologies. If there is a need for treatment during lactation, breastfeeding should be discarded.

Reviews of Torvacard

Those reviews about Torvacard, which are available on the forums, allow us to conclude that the drug is sufficiently effective. It is widely prescribed by cardiologists to lower cholesterol and protect patients from stroke and heart attack. After 1-2 months of use, a significant reduction in cholesterol is observed. Some women indicate a pleasant side effect - weight loss.
Among the shortcomings is that the cholesterol medicine can cause insomnia and an itchy rash on the body.