Liprimar 10mg #100

Instruction for Liprimar

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Composition

The composition of the tablets includes the active ingredient atorvastatin.
Additional components: calcium carbonate, lactose monohydrate, MCC, croscarmellose sodium, hydroxypropylcellulose, polysorbate 80, magnesium stearate, hypromellose, polyethylene glycol, talc, titanium dioxide, simethicone emulsion.

Form of issue

Liprimar is produced in the form of film-coated tablets containing 10 mg, 20 mg, 40 mg and 80 mg of the active ingredient. Tablets are packaged on 7 or 10 tablets in aluminum or PVC blisters for 2-5 or 8, 10 blisters in a pack.

pharmachologic effect

The drug has lipid-lowering and hypocholesterolemic effects.

Pharmacodynamics and pharmacokinetics

Taking Liprimar can reduce cholesterol, as well as its production in the liver. Therefore, it is prescribed with acquired and hereditary hypercholesterolemia, mixed types of dyslipidemia and so on.
The effectiveness of this drug manifests itself in the homozygous familial form of hypercholesterolemia, when treatment with conventional lipid-lowering drugs does not work. Liprimar is also used to treat patients suffering from angina and other cardiovascular disorders, which reduces the risk of developing ischemia, complications and mortality.
With internal reception of atorvastatin, good absorption is noted. The maximum concentration in the plasma composition is reached after 2 hours and has a dependence on the adopted dosage.
Eating does not have a significant effect on the bioavailability of the substance. At the same time about 98% of atorvastatin comes into contact with plasma proteins. As a result of the metabolism of the main component, pharmacologically active substances are formed, the excretion of which occurs with bile and slightly with urine.

Indications for Liprimar

The main indications for Liprimar application:
    various forms of hypercholesterolemia, hyperlipidemia, disbetalipoproteinemia, hypertriglyceridemia;
    prevention of cardiovascular disease in patients with and without undesirable symptoms, but with clinical signs of the possible development of myocardial infarction, angina pectoris, stroke, and so on.

Contraindications for use

The drug is not prescribed when:
    high sensitivity to its components;
    active diseases and liver disorders;
    age to 18 years.
Liprimar should also be used with caution in patients who abuse alcohol and suffer from liver disease.

Side effects

As a rule, patients tolerate Lipimar well, but the development of side effects should not be ruled out.
Sometimes, taking this medication can cause side effects that affect the functioning of the nervous system: headache, sleep problems, asthenic syndrome.
Also possible: nausea, diarrhea, abdominal pain, constipation, indigestion, flatulence. There may be irregularities in the functioning of the musculoskeletal system and the condition of the connective tissue.
In rare cases, note: amnesia, paresthesia, peripheral neuropathy, hypesthesia, anorexia, hepatitis, cholestatic jaundice, allergic reactions and so on.

Liprimar - instructions for use (Method and dosage)

As the instruction on Liprimar application informs, these tablets are intended for ingestion. Starting treatment with atorvastatin, pre-determine the level of cholesterol in the blood, and then prescribe a diet and exercise. Usually, Liprimar is recommended when other non-medicamentous methods become ineffective.
The intake of these pills does not depend on eating and the time of day. In this case, the daily dose assumes a single dose. After 2-4 weeks, dosage adjustment is possible, at the discretion of the attending physician. Development of therapeutic effect is observed after 2 weeks. The maximum concentration is achieved in a month from the beginning of the reception.
Liprimar treatment can increase the activity of liver enzymes, so regular monitoring of liver function is required during this period.

Overdose

In cases of overdose, there may be an aggravation of side effects. Since there is no specific treatment, then therapy is performed depending on the symptomatology that has appeared.

Interaction

Simultaneous use with cyclosporine, fibrates, erythromycin, clarithromycin, antifungals and nicotinic acid may increase the risk of myopathy.
The combination of atorvastatin with the cytochrome CYP3A4 isoenzyme, erythromycin, clarithromycin, diltiazem increases the concentration of the substance in the blood plasma.
Combinations with preparations containing magnesium hydroxide or aluminum hydroxide, as well as with colestipol, can reduce the concentration of atorvastatin in the blood plasma.
The combination of this drug with digoxin and oral contraceptives containing norethisterone and ethinyl estradiol significantly increases their concentration in the body.

Storage conditions

For storage of tablets is intended a dry, dark, cool place, inaccessible to children.
Shelf life - 3 years.

Alcohol

There is no direct contraindication to alcohol consumption during treatment with this drug, but since alcohol is an additional burden on the liver, it is better to refuse from alcohol.

Reviews of Liprimar

This drug is often prescribed for people suffering from various disorders in the work of the cardiovascular system. At the same time, patients' opinions about Liprimar are of different nature. Quite often there are reports that tell about the high effectiveness of treatment.
However, some patients are unhappy that the appointment of this drug, experts do not explain how to properly take the pill. Therefore, they try to independently select, and often adjust the dosage. As a result, various symptoms begin to manifest, the Lypomaros are unusual - blood thinning, bruising and bruising, and so on.
According to doctors, this drug is one of the most effective, provided that the prescribed dosage, schedule and duration of treatment are strictly observed. If it becomes incomprehensible to patients, it is always possible to clarify all the features of therapy in the attending physician. In addition, during the period of treatment you need to monitor the blood condition, follow a diet and perform appropriate physical exercises.