Crestor tabs 10mg #28

Crestor instruction for use

You can buy Crestor tablets here

Composition

One tablet contains 5, 10, 20 or 40 mg of rosuvastatin calcium and additional substances (monocrystalline cellulose, crospovidone, lactose monohydrate, calcium phosphate, hypromellose, E171, E172, glycerol triacetate, magnesium stearate).
INN: rosuvastatin.

Form of issue

Round or oval (40 mg), in a film shell, tablets of different colors, depending on the dosage.
Colors: yellow (5 mg), pink (10, 20, 40 mg). On one side of the engraving ZD4522 5, ZD4522 10, ZD4522 20, respectively, the content of the active substance. For a dosage of 40 mg, on the one hand is written ZD4522, on the other - 40.
Cardboard packaging with blisters, 28 pieces per pack. For 10 mg - 7, 28 and 98 tablets.

pharmachologic effect

Lipid-lowering.

Pharmacodynamics and pharmacokinetics

The active substance of the drug is a selective inhibitor of HMG-CoA reductase. Rosuvastatin significantly reduces the level of lipoproteins of low and extremely low density in the blood, by increasing the number of hepatic receptors that react to low-density lipoproteins. Thus, catabolism and the processes of capturing low density lipoproteins in the liver are accelerated, formation of very low density lipoproteins is suppressed.
The level of cholesterol, triglycerides, apolipoprotein B, TG VLDL, cholesterol, LDL cholesterol, and so on. decreases. The therapeutic effect becomes noticeable after 7 days of drug administration, after 14 days it reaches its maximum.
The maximum concentration in the blood - after 5 hours, cumulation - in the liver. It binds well to plasma proteins, almost completely (90%). About 10% of the active substance is metabolized. The withdrawal occurs with feces and, to a small extent, through the kidneys. In patients with severe impairment of the liver, a change in pharmacokinetic parameters was observed.

Indications for use

The medicine is used:
    as a preventive or therapeutic agent for familial homozygous hypercholesterolemia;
    as part of complex measures (diet, exercise, weight loss) with mixed hypercholesterolemia;
    treatment of atherosclerosis;
    as a prophylaxis with a predisposition to cardiovascular disease.

Contraindications

    severe liver disease, especially associated with increased transaminase levels;
    breastfeeding and pregnancy;
    patients taking cyclosporine;
    myopathy, at the risk of myopathy, the dosage is reduced;
    children (up to 18 years);
    allergy, to any of the components of the drug.

Side effects

    headache, polyneuropathy;
    Myopathy, pain in the muscles and joints;
    various allergic reactions;
    nausea, pancreatitis, constipation, diarrhea;
    asthenia;
    tubular proteinuria.

Instructions for use of the Crestor (Method and dosage)

Tablets are taken regardless of food intake, not breaking and not chewing.
Dosage and duration of the drug should be prescribed by a doctor.
According to instructions for the use of Crestor, the first time taking the drug and patients with a low need for it, the daily dose is set at a limit of 5-10 mg. After 21 days, if necessary, the dosage can be increased. With an increase in daily intake of Crestor to 40 mg, you should closely monitor the patient's condition, especially in the first couple of days of switching to a new dosage.
In patients with an average degree of renal failure, a starting dose of 5 mg per day. Further - up to 40 mg / day.
For Mongoloids, due to the peculiarities of the functioning of the liver, the initial dose is 5 mg per day. Contraindicated the appointment and reception of doses exceeding 20 mg per day.
In persons prone to myopathy, more than 20 mg per day is contraindicated.

Overdose

In case of an overdose, side effects increase. Hemodialysis is ineffective, there is no specific antidote.
Therapy - according to the symptoms + control of hepatic enzymes.

Interaction

It is not recommended to combine with cyclosporine.
There is a change in the plasma concentration of Crestor when combined with other lipid-lowering drugs (hemifibrozil).
The drug affects the prothrombin index, therefore, it is not recommended to combine it with antagonists of vitamin K, warfarin.
The frequency of manifestation and the nature of adverse reactions may change with the use of rosuvastatin with ezetimibe.
Various fibrates, hemofibrates, nicotinic acid and gemfibrozil increase the likelihood of myopathy. Their combination with the Crestor is not recommended.
Undesirable simultaneous administration of the drug with protease inhibitors, ritonavir, lopinavir, erythromycin, antacids, oral contraceptives.

Terms of sale

To buy Crestor you don't need a prescription.

Storage conditions

Do not allow children to fall into the hands. Store in a cool place.
Shelf life - 3 years.

Reviews of Crestor

There are very few reviews of Crestor on the forums. The drug appeared on the domestic market relatively recently. The drug is actively used to treat hyperlipidemia, especially in people who have had heart attacks and strokes. Among the side effects may be headaches and sleep disturbance. During the administration of the drug, special attention should be paid to the control of the blood composition and the level of liver enzymes.