Mertenil tabs 20mg #30

Mertenil user manual

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Composition

The preparation Mertenil in one tablet contains active substance rosuvastatin calcium - 10,4 mg, and also auxiliary substances: cellulose microcrystalline 12, magnesium hydroxide, magnesium stearate, lactose monohydrate, crospovidone (type A).
The composition of the film shell is opadrai II white (talc, titanium dioxide (E171), macrogol 3350 and polyvinyl alcohol).

Form of issue

Round and biconcave tablets in a film shell with an engraving "C34". 10 pieces in one cell outline package (3 pieces in one carton pack).

Pharmacological action

A hypolipidemic drug for the prevention and treatment of atherosclerosis. Reduces the level of low-density lipoprotein cholesterol and increases the level of high-density lipoprotein cholesterol.

Pharmacodynamics and pharmacokinetics

Mertenil tablets are a selective and competitive enzyme inhibitor that converts HMG-CoA to mevalonate. When applied, it has the main effect, where it performs the synthesis of cholesterol and catabolism of LDL (low-density lipoprotein). It binds to blood plasma proteins by approximately 90%. Metabolism is limited - 10%.
Calcium rosuvastatin reduces the level of total cholesterol and LDL cholesterol. The drug is excreted from the body in a natural way. Its systemic exposure increases in direct proportion to the dose taken.
Effective for treating people with hypercholesterolemia, regardless of gender and age.
The maximum concentration of active substance in the blood plasma is reached approximately 5 hours after taking the appropriate dose. Bioavailability is approximately 20%.
The first effect of the use of the drug is visible in a week. The maximum possible positive changes are achieved after 1 month of admission and are maintained with further use of the drug.

Indications for use Mertenil

Indications for the use of Mertenil may be as follows:
    hypercholesterolemia;
    combined dyslipidemic states;
    Type IV hypertriglyceridemia by Fredrickson;
    family homozygous hypercholesterolemia;
    prevention and treatment of atherosclerosis;
    prevention of cardiovascular complications (heart attack, arterial revascularization, stroke, etc.).
The medicine is often prescribed as an addition to diet therapy, when dietary nutrition itself and other methods of lipid-lowering therapy, for example, physical activity, are not enough.

Contraindications

Mertenil in tablets of 5, 10 and 20 mg is not recommended:
    pregnant women;
    during lactation;
    women of childbearing age who use unreliable contraceptives;
    with hepatic insufficiency;
    when using fibrates with cyclosporine;
    in case of lack of lactase and lactose intolerance;
    with functional problems with the kidneys;
    people with a predisposition to myotoxic complications;
    in the case of myopathy;
    with increased sensitivity and individual intolerance of some components of the drug;
    in the case of glucose-galactose malabsorption.
Tablets Mertenil on 40 mg it is forbidden to accept at:
    hypothyroidism;
    excessive use of alcoholic beverages;
    liver diseases in the active phase;
    personal or family history of diseases of the muscular tissue.
Such dosages also do not recommend patients of the Asian race.
In addition, Mertenil with caution appoint at:
    metabolic, electrolyte and endocrine disorders of a serious degree;
    uncontrolled epilepsy;
    arterial hypotension;
    sepsis;
    increased risk of appearance and development of myopathy;
    history of past history;
    injuries;
    extensive surgical interventions.
In addition, caution should be taken for people over 65 years of age. And its effectiveness and safety for children are not yet established.

Side effects

The common side effects of the Mertenil may be as follows:
    development of type II diabetes mellitus;
    asthenic syndrome;
    dizziness;
    constipation;
    nausea;
    stomach ache;
    headache;
    myalgia.
In rare cases, there may be a rash, itchy skin, myopathy, rhabdomyolysis, pancreatitis, urticaria. And with the regular intake of tablets of 40 mg may develop myalgia, proteinuria and myopathy. In addition, at this dosage, the concentration of bilirubin and glucose can increase, and the thyroid gland may be damaged.
In addition, if you are taking Mertenil, the instructions for use indicate that in very rare cases arthralgia, jaundice, hepatitis, memory loss, dyspnea, peripheral edema, diarrhea, hematuria, polyneuropathy, cough may occur.
However, the side effects that can be caused by the use of Mertenil are usually short-term or mild. In many cases, they depend on the dosage of the drug. So the instructions for the use of the Herzenyl must be observed strictly.
In case of sudden pain in the muscles or the development of muscle weakness, which is accompanied by a general malaise and fever, stop taking the medication immediately and consult a doctor.

Instructions for use

Take the drug can be at any time inside with a small amount of water. However, its reception must necessarily be combined with dietary nutrition, agreed with a specialist. The daily diet should consist of foods that are low in fat.
In each case, the dose of medication for the patient is selected individually. First of all, it depends on the purpose of treatment. When adjusting the dosage, the total cholesterol level in each patient is taken into account, as well as the risk of cardiovascular complications and possible side effects.
The minimum dosage is usually 5-10 mg per day. Gradually (but not earlier than a month) the dose can be increased. Tablets of 40 mg are best taken under constant medical supervision.

Overdose

In case of an overdose, symptomatic treatment is performed. Hemodialysis is ineffective. It is important to monitor liver function and the degree of activity of CK.

Interaction

It is very important to combine mitrenil with other drugs. If you accept:
    Cyclosporin - AUC Mertenil (area under the curve "concentration-time") is increased by 7 times.
    Ezetimibe - a change in the AUC and the concentration of both drugs. The probability of occurrence of undesirable phenomena.
    Inhibitors of proteases - it is possible to extend the systemic action of Mertenil.
    Erythromycin - decrease in AUC0-t and Cmax of Mertenil.
    Antagonists of vitamin K - may increase the INR (the international normalized relationship).
    Gemfibrozil and other drugs that reduce lipid levels - an increase of 2 times the concentration and AUC of Mertenil. Possible risk of myopathy. The simultaneous use of tablets Merenil for 40 mg and fibrates is prohibited. The dose of rosuvastatin should not be more than 5 mg.
    Antacids - in suspensions containing aluminum or magnesium hydroxide, can cause a decrease in the concentration of Mertenil in blood plasma by about half.
    Oral contraceptives and hormone replacement therapy - it is possible to increase the ethinylestradiol AUC by 26% and norgestrel by 34%.
    Isozymes of cytochrome P450 - possibly a slight increase in AUC of Mertenil.

Terms of sale

To buy Mertenil you don't need a prescription.

Storage conditions

Keep Mertenil tablets in a dry place and protected from direct sunlight. The temperature should not be above 30 ° C.
Shelf life - 2 years.

Reviews of Mertenil

On the forums reviews about the Mertenil are mostly positive. As a rule, he does not cause side effects. The overall well-being of patients taking cholesterol tablets does not deteriorate.
Experts, in turn, discuss whether it is justified at all to use statins and what should be the dosages of this drug in each specific case.