Rosart tabs 20mg #30

Rosart user manual

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Composition

Rosart contains the active substance rosuvastatin in the amount of 5,10, 20 and 40 milligrams, as well as auxiliary substances:
    microcrystalline cellulose;
    crospovidone;
    calcium hydrogen phosphate dihydrate;
    lactose monohydrate;
    magnesium stearate.
The rosacea tablet consists of:
    hypromellose;
    titanium dioxide;
    lactose monohydrate;
    macrogol;
    triacetin.

Form of issue

    Tablets are 5 milligrams white, round in a film shell. On one side is marked ST 1.
    Tablets of 10 milligrams of pink color, round in a film shell. On one side is marked ST 2.
    Tablets of 20 milligrams of pink color, round in a film shell. On one side is marked ST 3.
    Tablets of 40 milligrams of pink color, oval in a film shell. On one side is marked ST 4.

pharmachologic effect

Rosart belongs to the class of statin drugs, which is used to treat high cholesterol and related conditions, as well as to prevent cardiovascular diseases.

Pharmacodynamics and pharmacokinetics

Rosart is a selective and competitive inhibitor of HMG-CoA reductase, which limits enzymes in the synthesis of cholesterol. It increases the number of hepatic LDL receptors on the cell surface, increasing the uptake and catabolism of LDL. It also reduces the level of apolipoprotein B, triglycerides and increases HDL.
In 1 week of taking the drug, the active substances are not completely absorbed and absorbed in the gastrointestinal tract. Bioavailability is approximately 20%. The maximum plasma concentration is achieved 5 hours after oral administration.
Binding to protein is 90%. Metabolism is carried out in the liver. Excretion with feces (90% oral dose) after approximately 19 hours (half-life).

Indications for use

Rosart is indicated for use when:
    Hypercholesterolemia of the second type according to Fredrikson's classification (a state of pre-illness that can develop into atherosclerosis without proper treatment), including heterozygous form (hereditary) or mixed form (combined) of hyperlipidemia. The drug is used in combination with other non-medicamentous measures aimed at reducing body weight and cholesterol level in the blood.
    Hypertriglyceridemia of the fourth type according to Frederickson classification. The drug is used in combination with a diet developed by a dietician.
    Need to reduce the rate of atherosclerosis. The drug is used as a supplement to the diet in people to whom the specialist has already prescribed therapeutic measures to reduce the level of total cholesterol and LDL cholesterol.
    To prevent the development of diseases of the cardiovascular system, as well as their complications - myocardial infarction, stroke, ischemic heart disease.

Contraindications

Medicine Rosart has several serious contraindications:
    intolerance to any ingredient in the drug;
    active liver disease or unexplained functional abnormalities of liver function;
    pregnancy;
    pregnancy planning;
    lactation period;
    age to 18 years;
    myopathy;
    renal failure and renal dysfunction.
Rosart should be used with great care, if:
    if the patient is prescribed therapeutic treatment with medicinal preparations;
    if the patient uses methods of alternative medicine (treatment with homeopathic remedies, herbs, etc.);
    with regular muscle spasms;
    with low blood pressure;
    with severe infectious diseases;
    at violations of the thyroid gland function;
    with diabetes;
    with dehydration;
    with excessive physical exertion.

Side effects

Side effects are rare. The following side effects should be reported to the doctor if they persist or worsen:
    constipation;
    heartburn;
    dizziness;
    problems with sleep;
    depression;
    pain in the joints;
    cough;
    loss of memory or forgetfulness;
    confusion of consciousness.
The following side effects are more serious. If they are present, Rosart should be discontinued and immediately consult a doctor. Such adverse reactions include:
    muscle pain or weakness;
    fever;
    chest pain;
    yellowing of the skin or eyes;
    darkening of urine;
    pain in the right upper abdomen;
    nausea;
    extreme fatigue;
    unusual bleeding or bruising;
    loss of appetite;
    influenza-like symptoms;
    sore throat, chills, or other signs of infection.
If any signs of an allergic reaction develop, you need to contact emergency medical help immediately:
    rash;
    hives;
    itching;
    shortness of breath or swallowing;
    swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or legs;
    hoarseness;
    numbness or tingling in the fingers and toes.

Instructions for using Rosart

In the instructions for use Rosart 10 mg says that the drug is taken orally without first comminuting. Drink the preparation with a sufficient amount of liquid, preferably water. The intake of tablets does not depend on the intake of food.
According to the instructions for use Rosart 10 milligrams, take the drug with a minimum dosage of 5 milligrams or 10 milligrams, even if previously taken high doses of other statins. The choice of initial dosage depends on:
    cholesterol level;
    the level of risk of a heart attack or stroke;
    the level of susceptibility to the components of the drug.
With an initial dosage of 5 milligrams, the doctor can double this dose to 10 milligrams, and then increase to 20 milligrams and 40 milligrams if necessary.
Between each dose adjustment should take four weeks. The maximum daily dosage is 40 milligrams. This dose is prescribed only to patients with high cholesterol and a high risk of developing a heart attack or stroke, where a dosage of 20 milligrams is sufficient to lower the level of cholesterol in the blood.
When prescribing the drug to reduce the risk of a heart attack, stroke, or their
related health problems, the recommended daily dose is 20 mg. Dosage can be reduced if the patient has symptoms on the list of contraindications.
The dose for children between the ages of ten and seventeen years - the usual initial dosage is 5 milligrams, the maximum daily dose is 20 mg. The drug should be taken once a day.
Medicine Rosart, according to the instructions for use, in a dosage of 40 mg prescribe to children is not recommended.

Overdose

Symptoms of an overdose of Rosart are similar to those of a side effect of the drug. If they are severe, you need to seek help from a specialist who prescribes symptomatic treatment.
In this case, hemodialysis will be ineffective.

Interaction with other drugs

Rosart with simultaneous reception with some medicines can provoke the appearance of undesirable reactions:
    Admission Rosart with Ciclosporin - the latter drug stimulates multiple increases in systemic exposure of rosuvastatin, so patients who are prescribed ciclosporin should take Rosart at the lowest dosage - no more than 5 milligrams per day.
    Hemofibrozil (Gemfibrozil) - significantly increases the systemic exposure of rosuvastatin. In connection with the observed increased risk of myopathy / rhabdomyolysis, combined therapy of Rosartha and Gemfibrozil should be avoided. The maximum dosage should not exceed 10 milligrams per day.
    Protease inhibitors - the combined use of Rosart with certain protease inhibitors in combination with ritonavir has various effects on rosuvastatin, or rather on the effect of the substance on the body. Protease inhibitors in combinations: lopinavir / ritonavir and atazanavir / ritonavir can increase the systemic exposure of rosuvastatin up to three times. For these combinations, the dose of Rosartha should not exceed 10 milligrams once a day.

Terms of sale

To buy Rosart online the prescription is not required.

Storage conditions

Store Rosart in a dark place at a temperature of no higher than 30C Celsius.
Shelf life - 36 months.

Reviews of Rosart

Today on the Internet you can find a large number of reviews about Rosart. I would like to draw your attention to the reviews of doctors who, in view of their high qualifications and extensive experience in the treatment of diseases associated with high cholesterol, characterize this drug as quite complex.
Specialists warn patients and colleagues from the haphazard reception of tablets, because improper treatment can lead to the development of more complex diseases. The drug has a mass of side effects, and several cases of rhabdomyolysis have been reported.
Patients, in turn, express in the forums full satisfaction with the effect provided by the drug Rosart. Many people write that after taking this drug they did not experience any adverse reactions, and their well-being improved significantly.