Rozucard tabs 20mg #90

Rozucard user manual

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Composition

Rosuvastatin is the active active substance of the drug. In addition, it contains the following additional components: magnesium stearate, lactose monohydrate, MCC, croscarmellose sodium, silicon dioxide colloid.
The composition of the film shell include: iron dye red oxide, hypromellose, titanium dioxide, macrogol 6000, talc.

Form of issue

Oval tablets in a shell of pink, dark pink or light pink.

pharmachologic effect

The drug is a lipid-lowering drug.

Pharmacodynamics and pharmacokinetics

Rozucard belongs to the group of statins. It inhibits HMG-CoA reductase, an enzyme that converts HMG-CoA to mevalonate.
In addition, this agent increases the number of LDL receptors on hepatocytes, which increases the intensity of catabolism and the capture of LDL and causes inhibition of VLDL synthesis, reducing the total content of VLDL and LDL. The drug reduces the concentration of LDL-C, HDL-cholesterol, high-density cholesterol, X-VLDL, TG, apolipoprotein B, TG-VLDL, total Xc, and also increases the content of ApoA-1 and X-HDL. In addition, it reduces the ratio of ApoB and ApoA-1, Xc-non-HDL and Xc-HDL, Xc-LDL and Xc-HDL, total Xc and Xc-HDL.
The main effect of the Rozucard is directly proportional to the prescribed dosage. The therapeutic effect after the beginning of treatment is noticeable in a week, about a month later it becomes maximum, and then becomes stronger and becomes permanent.
The maximum concentration of the main active substance in the plasma is established after 5 hours. Absolute bioavailability is 20%. The degree of connection with blood plasma proteins is about 90%.
With regular use, the pharmacokinetics do not change.
Rozucard is metabolized through the liver. Well penetrates the placental barrier. The main metabolites are N-dysmethyl and lactone metabolites.
The half-life is approximately 19 hours, but it does not change if the dosage of the drug is increased. Plasma clearance of an average of 50 l / h. Approximately 90% of the active substance is excreted intestine unchanged, the rest - through the kidneys.
Sex and age on the pharmacokinetics of Rozucard are not influenced. However, it depends on race. In Indians, the maximum concentration and the average value of AUC are approximately 1.3 times higher than in the representatives of the Caucasoid race. AUC in people of the Mongoloid race is 2 times larger.

Indications for use of Rozucard

Indications for the use of Rozucard are as follows:
    primary hypercholesterolemia or mixed dyslipidemia - the drug is used as a supplement to the diet, if dietary intake alone is insufficient;
    the need to slow the development of atherosclerosis - the drug is used as a supplement to the diet as part of the treatment to reduce the level of total cholesterol and LDL cholesterol to normal levels;
    family homozygous hypercholesterolemia - the drug is used as a supplement to the diet or as a component of lipid-lowering therapy;
    the need to prevent complications in the functioning of the cardiovascular system with an increased risk of atherosclerotic cardiovascular disease - the drug is used as part of therapy.

Contraindications

The medicine can not be used when:
    hypersensitivity to its components;
    severe kidney disease;
    liver diseases in the active phase;
    myopathy;
    pregnancy;
    lactation.
Rozucard also is contraindicated in women of reproductive age who do not use contraceptive measures.
Dosage of 40 mg can not be taken by people with factors that contribute to the development of myopathy and rhabdomyolysis, namely:
    disorders of the kidneys of moderate severity;
    hereditary muscle diseases in an individual or family anamnesis;
    alcoholism;
    hypothyroidism;
    myotoxicity, provoked by HMG-CoA reductase inhibitors or fibrates, in the anamnesis.
The risk group, in addition, includes patients of the Mongoloid race, as well as those who take fibrates. This dosage is contraindicated in situations that may cause an increase in the content of the drug in the blood plasma.

Side effects

Adverse reactions from the use of the drug can be as follows:
    nervous system: headache, asthenic syndrome, dizziness;
    respiratory system: cough, dyspnea;
    musculoskeletal system: myalgia;
    skin and subcutaneous tissue: peripheral edema, Stevens-Johnson syndrome;
    laboratory parameters: transient increase in serum CKK activity depending on dosage;
    allergic reactions: itching, urticaria, rash;
    digestive system: nausea, pain in the abdomen, constipation, vomiting, diarrhea;
    Endocrine system: Type II diabetes mellitus;
    urinary system: proteinuria, urinary tract infections.
In rare cases, peripheral neuropathy, pancreatitis, memory loss, hepatitis, jaundice, myopathy, rhabdomyolysis, angioneurotic edema, hematuria, transient elevation of AST and ALT.

Instructions for using Rozucard (Method and dosage)

Before the course of Rozucard, the patient must necessarily switch to standard lipid-lowering dietary nutrition, which must be maintained during the entire therapy. Dosages are determined in each case individually depending on the disease and the characteristics of the patients.
For those who have been assigned Rozucard, the instructions for use inform you that you can consume it at any time, before or after a meal.
With hypercholesterolemia, the initial dose recommended by specialists is 5 or 10 mg orally. Instructions for use Rozucard provides for its reception once a day. The choice of initial dosage should take into account individual cholesterol levels, the likelihood of negative reactions, and the risk of developing cardiovascular diseases. After 4 weeks it can be changed. At dosages of 40 mg, specialist supervision and correction are necessary if necessary.
For the prevention of cardiovascular disease, a daily dose of 20 mg is recommended.
For children older than 10 years with hereditary hypercholesterolemia, the initial dosage, as a rule, is 5 mg / day. During the treatment, it can be gradually increased, but not exceed 20 mg. Titration is carried out depending on individual tolerability. Prior to the start of the course of the drug should follow the standard diet to reduce the cholesterol in the body. During treatment with Rozucard also be sure to adhere to this power system.
Patients in the elderly (over 70 years) are usually prescribed a dosage of 5 mg.
For people with mild or moderate impairment of renal function at the beginning of the course, in most cases, 5 mg is prescribed. During the treatment, dosage above 40 mg should not be used. In severe violations of kidney function, this medicine is contraindicated.
For patients of the Mongoloid race and those who are predisposed to myopathy, an initial dosage of 5 mg is recommended. Taking a dose of 40 mg is strictly contraindicated.

Overdose

When using the drug in elevated doses, side effects are intensified.
Prescribe symptomatic treatment. It is necessary to monitor the level of CK and liver function. Hemodialysis is ineffective.

Interaction

Ciclosporin in combination with Rozucard increases its AUC value by about 7 times. Taking more than 5 mg is not recommended.
Gemfibrozil and other lipid-lowering medications in combination with Rozucard causes an increase in its maximum concentration and AUC approximately twice. Increased risk of myopathy. The maximum dose when combined with gemfibrozilom - 20 mg. When interacting with fibrates, the dosage of the drug in 40 mg is not allowed, the initial dose is 5 mg.
The interaction of the drug with protease inhibitors may lead to an increase in the exposure of Rosuvastatin. It is not recommended to use this combination of HIV-infected patients.
The combination of Erythromycin and Rozucard reduces the AUC of the latter by 20%, and the maximum concentration by 30%.
When this drug is combined with Lopinavir and Ritonavir, its equilibrium AUC and maximum concentration values ​​increase.
Vitamin K antagonists when interacting with Rozucard cause an increase in the international normalized relationship.
Ezetimibe concurrent with rosuvastatin may provoke the occurrence of side effects.
Antacid drugs with aluminum or magnesium hydroxide reduce the amount of the drug in the body by about half. So between their reception you need to take a break, at least, 2 hours.
When Rozucard is combined with oral contraceptives, patients need to be monitored.

Terms of sale

You don't need a prescription to buy Rozucard online.

Storage conditions

Store the drug only in its original packaging, in a well-protected from moisture and light. The temperature should be up to 25 degrees.
Shelf life - 2 years.

Reviews of Rozucard

Reviews about Rozucard are mostly positive. This remedy is often advised by doctors. It is quite affordable, so its purchase does not cause difficulties. Those who have already undergone a course of treatment with this drug, leave feedback on Rozucard, which reported that the drug helped them maintain a normal level of cholesterol and stop the progression of the disease.