Trimektal MB tabs 35mg #120

User manual for Trimektal MB

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Composition

1 tablet contains 35 mg of trimetazidine dihydrochloride - the active ingredient.
Additional Ingredients:
    137.5 mg of colloidone SR (0.2% of silicon dioxide, 19% of povidone, 80% of polyvinyl acetate, 0.8% of sodium lauryl sulfate);
    2.5 mg magnesium stearate;
    1.2 mg of colloidal silicon dioxide;
    73.8 mg of calcium dihydrate hydrophosphate.
Film Sheath:
    4.8 mg - hypromellose;
    1.6 mg - talc;
    0.88 mg of titanium dioxide;
    0.72 mg - macrogol 4000.

Form of issue

The preparation Trimectal MB is available in the form of tablets with a film coating of 60 or 120 pieces per pack.

pharmachologic effect

Antihypoxic.

Pharmacodynamics and pharmacokinetics

In the brain, trimetazidine has a direct effect on neurons and cardiomyocytes, optimizing their function and metabolism.
The cytoprotective effect of the drug is due to the increase in the energy resource, the activation of oxidative decarboxylation, and the improvement of oxygen consumption, by forcing the aerobic glycolysis and blocking the oxidation of fatty acids.
The drug supports the contractile function of the myocardium, prevents a decrease in the amount of intracellular phosphocreatine and ATP. When acidosis maintains the normal operation of membrane ion channels, inhibits cumulation of sodium and calcium ions in cardiomyocytes, normalizes the concentration of potassium ions inside the cell.
Reduces the increased amount of phosphate and intracellular acidosis, which are caused by reperfusion and myocardial ischemia. Prevents the damaging effect of free radicals and the activation of neutrophils in the field of ischemia, promotes the preservation of the integrity of cell membranes, increases the long-term electrical potential, reduces the yield of creatine phosphokinase and the severity of ischemic disturbances in the myocardium.
Trimectal MB reduces the number of possible attacks of angina and reduces the patient's need for nitrates. After 14 days of admission, there is an increase in tolerance to physical exertion and a decrease in sudden fluctuations in blood pressure.
Also, the drug reduces possible tinnitus and associated dizziness. When diseases of the organs of vision of vascular origin are beneficial to the functionality of the retina of the eye.
After oral (internal) reception, trimetazidine is rapidly and almost 100% absorbed in the gastric tract. Bioavailability is 90%. Plasma Tmax is 3 hours. Relationship with plasma proteins 16%.
Achievement of a stable state is observed for 60 hours. Vd at 4.8 l / kg, which implies good penetration into the tissue.
T1 / 2 for about 7 hours, in patients after 65 years of age it rises to 12 hours. It is excreted mainly with urine (approximately 60% of the drug in unchanged form).
With age, the hepatic clearance of trimetazidine decreases, and the renal clearance directly correlates with QC. The drug easily passes the histohematological barriers.

Indications for use

Indications for use of Trimectal MB in cardiology (as part of complex treatment):
    angina, as a prophylaxis of seizures;
    IHD (ischemic heart disease);
    cochleovestibular disorders of ischemic etiology, including tinnitus, dizziness, auditory disorders.
Indications for use Trimectal MB in ophthalmology:
    chorioretinal disorders of vascular etiology with ischemic disorders.

Contraindications

    hypersensitivity to trimetazidine or another pill or shell component;
    pregnancy;
    kidney failure in chronic form (with CC less than 15 ml / min);
    lactation;
    pathology of the liver of a pronounced character;
    age to 18 years.

Side effects

CNS:
    Symptoms of Parkinsonism (including tremor, tone increase, akinesia);
    dizziness;
    gait unsteadiness and instability in the Romberg pose;
    insomnia;
    headache;
    restless legs syndrome;
    other motor impairments (usually occurring after withdrawal of therapy);
    drowsiness.
Digestive system:
    stomach ache;
    dyspepsia;
    diarrhea;
    nausea, with possible transition to vomiting;
    constipation.
The cardiovascular system:
    palpitation;
    marked decrease in blood pressure;
    tachycardia;
    extrasystole;
    Orthostatic hypotension, accompanied by weakness, loss of balance, dizziness, especially when taking hypotensive drugs in parallel;
    tides.
Skin:
    rash on the skin;
    hives;
    itching;
    acute exanthematous generalized pustulosis;
    angioedema.
Circulatory system:
    agranulocytosis;
    thrombocytopenic purpura;
    thrombocytopenia.
Are common:
    asthenia;
    hepatitis.

Instructions for use

Tablets of the drug are intended for oral (internal) reception, during meals.
As a rule, Trimectal MB is prescribed 1 tablet (35 mg) twice in 24 hours (morning and evening).
The duration of treatment is determined by the attending physician strictly individually.

Overdose

At this time there are no reports of cases of an overdose of Trimectal MB.

Interaction

Trimectal MB promotes anti-ischemic efficacy of other antianginal agents.

Terms of sale

To buy Trimectal MB you don't need the prescription.

Storage conditions

The tablets are stored in a dry, darkened room, the temperature of which does not exceed 25 ° C.
Shelf life - 24 months.

special instructions

It is not prescribed to prevent attacks of angina pectoris.
It is not used for the initial course of treatment of myocardial infarction or unstable angina.
In the event of an angina attack, treatment should be reviewed.

Children

Tablets Trimectal MB are contraindicated in taking up to 18 years of age.

In pregnancy and lactation

It is not prescribed during lactation (should be from breastfeeding) and pregnancy.

Reviews of Trimectal MB

As a rule, this drug is prescribed in combination with other drugs, so it is difficult to determine the degree of its positive effect on the patient's body.
Despite this, positive responses about Trimectal MB are encountered quite often, which, together with the minimal number of negative evaluations of its effectiveness, makes it possible to presume the expediency of using this drug, with the condition that there are no contraindications and the need for its administration.