Cardionate caps 250mg #40

Cardionate instruction for use

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Composition

Capsules
1 capsule includes 250 mg or 500 mg of Mildonia dihydrate is an active substance.
Auxiliary Ingredients:
    potato starch;
    colloidal silicon dioxide;
    calcium stearate.

Form of issue

The drug Cardionate is produced in two pharmaceutical forms:
    capsules hard gelatinous on 20, 40 or 100 pieces in one packing;
    injection solution - 5 or 10 ampoules of 5 ml in one package.

pharmachologic effect

Cardioprotective, metabolic.

Pharmacodynamics and pharmacokinetics

Cardionate is a synthetic analogue of gamma-butyrobetaine, therefore, it inhibits gamma-butyrobetaine hydroxylase, lowers the replication of carnitine and the transport of fatty acids (long chain) through the cell membranes, inhibits the process of accumulation of activated fatty acids in the unoxidized state (derivatives of acylcoenzyme A and acylcarnitine) .
Meldonium possesses cardioprotective properties, normalizing myocardial metabolism. When ischemia takes an active part in restoring the equilibrium between the processes of oxygen supply to cells and its intracellular intake, prevents disruption in the transport of ATP. At the same time, it activates glycolysis, which passes without additional expenditure of oxygen. Due to a decrease in the content of carnitine, the synthesis of gamma-butyrobetaine passes at an accelerated rate, which is why a pronounced vasodilating effect is manifested.
The mechanism of action of Cardionate determines the multiplicity of its therapeutic effects, among which: increased efficiency, reduced symptoms of physical and psychological overstrain, cardioprotective effect, activation of humoral and tissue immunity. In conditions of acute myocardial ischemia, the development of the necrotic zone slows down, and the rehabilitation period is reduced.
With heart failure (CH) increases myocardial contractility, significantly increases the possibility of physical exertion and time, reduces the frequency of possible attacks of angina pectoris.
In case of disturbances in the cerebral circulation system of the chronic and acute nature of the ischemic nature, it positively influences the blood circulation in the lesion site, and also regulates its redistribution towards the ischemic site.
Cardiovascular is effective in cases of vascular and dystrophic changes in the fundus and toning affects the central nervous system. Takes part in the elimination of functional disorders of autonomic and somatic nervous systems in patients who suffer from chronic alcoholism, especially during the period of withdrawal.
After oral administration, it is rapidly absorbed into the digestive tract.
Achieves Cmax in blood plasma for 1-2 hours after application.
Bioavailability is about 78%.
Metabolism occurs with the formation of 2 major metabolites of the drug, which are excreted in the urine.
When taken orally, T1 / 2 depends on the dose taken and is between 3 and 6 hours.

Indications for use of Cardionate

Indications for the use of Cardionate in the form of capsules and an injection solution:
    decreased patient performance;
    physical overstrain, including people professionally involved in sports;
    acceleration of rehabilitation in postoperative periods;
    CHF (chronic heart failure) together with specific treatment, cardialgia due to dystrophy (dyshormonal) myocardium, ischemic heart disease (angina);
    abstinence syndrome (in combination with specific treatment);
    cerebrovascular insufficiency;
    stroke.
Also Cardionate in the form of a solution for injection appoint:
    with acute disturbance of the blood supply to the retina;
    with hemorrhages in the retina (for various reasons);
    with thrombosis of the central and peripheral veins of the retina;
    with retinopathy of different nature, including hypertension and diabetic (only parabulbarno is introduced).

Contraindications

    hypersensitivity to Meldonium or other components of the drug;
    diagnosed increased intracranial pressure (intracranial tumors, violation of venous outflow);
    the patient's age is up to 18 years (due to unsettled efficacy and safety);
    lactation and pregnancy.
With pathologies of the liver and / or kidneys, Cardionate is prescribed with extreme caution.

Side effects

When carrying out therapy with Cardionate, side effects are observed quite rarely and mainly manifest allergic reactions (rashes, redness, swelling, itching), as well as tachycardia, dyspeptic disorders, agitation and lowering of blood pressure.

Instructions for the use of Cardionate (Method and dosage)

For capsules
Capsules of the drug Cardionate is taken orally (by mouth), swallowing whole (without chewing and not dividing) and washing down with water.
It is better to take capsules in the first half of the day, since it is possible to develop an exciting effect.
With stable angina, Cardionate is taken 1-2 times in a daily dose of 250 mg - 500 mg, during the first 3 to 4 days of therapy. Then the drug is taken 2 times in 7 days, with a course of treatment from 30 to 45 days.
In cardialgia due to dyshormonal myocardial dystrophy, the recommended daily dose is 250 mg, with the course of therapy - 12 days.
With violations in the process of cerebral circulation of chronic course, 500 mg of Cardionate are recommended per day, for 14-21 days.
In chronic alcoholism, 500 mg of the drug are taken 4 times a day, with a course of treatment - 7-10 days.
When physical overexertion and reduced performance (including athletes), adults are prescribed 250 mg to 500 mg in 1-2 doses per day. The course of therapy takes 10-14 days. In case of necessity, a second course of treatment can be done after 2-3 weeks.
Professional athletes are recommended, before training, taking 250 mg - 500 mg of medicinal product per day. In the preparatory period of training the duration of admission is 14-21 days, during the competition - 10-14 days.

Overdose

Since the conducted studies showed low toxicity of Cardionate and a low probability of development of health-related side effects, cases of overdose, when applied, was not observed.

Interaction

Meldonium can enhance the effects of coronarodilating drugs, cardiac glycosides, as well as some antihypertensive drugs.
Possible simultaneous application of Cardionate with anticoagulants, antianginal agents, antiaggregants, diuretics, antiarrhythmics and bronchodilators.
Due to the possible manifestation of tachycardia, as well as arterial hypotension, caution should be exercised when combined with alpha-blockers, nitroglycerin, nifedipine, peripheral vasodilators and hypotensive drugs.

Storage conditions

At a temperature of no higher than 25 ° C.
Shelf life - 36 months.

special instructions

With prolonged treatment with Cardionate, patients with chronic liver and kidney pathologies, care must be taken.

Children

Due to the lack of reliable data on the influence of Cardionate on children of childhood, this drug is not prescribed for patients under 18 years of age.

During pregnancy (and lactation)

The safety of Cardionate during the entire period of pregnancy has not been proven. To avoid possible negative effects on the fetus, during this period the drug is not prescribed.
There is no reliable information about the isolation of Meldonium and its metabolites with the mother's milk. If there is a need for a nursing mother namely Cardionate, then for the period of treatment, breast-feeding is stopped.

Reviews about Cardionate

The doctors' comments about Cardionate position this drug as an inexpensive and effective drug for maintaining the vital functions of the organism at a high level. Good results were also shown in its use as part of complex treatment for CHF, IHD, and also during the recovery from a stroke.
Reviews about Cardionate at the forums only confirm the findings of doctors, a special place in positive reviews is the high effectiveness of the drug with withdrawal symptoms.