Zocardis tabs 30mg #28

Zocardis instruction

You can buy Zocardis here

Composition

This drug contains the active substance zofenopril and a number of auxiliary components:
    lactose monohydrate;
    magnesium stearate;
    corn starch;
    ICC;
    silica.

Form of issue

Tablets are oval in shape. Outside, covered with a shell of hypromellose, titanium dioxide, macrogol 400, macrogol 600. A two-sided notch is placed on the surface for a comfortable division of the tablet.

pharmachologic effect

Zocardis refers to ACE inhibitors (a group of natural and synthetic compounds that are used to treat cardiovascular diseases, kidney failure, and also to protect against ionizing radiation).
The drug is antihypertensive. The mechanism of action of the drug is based on the reduction of the formation of angiotensin II from angiotensin I. In the first case, a decrease in the release of aldosterone, also decreases systolic and diastolic blood pressure and reduces the degree of post- and preload of the myocardium.
The active substance of the drug contributes to the expansion of the arteries, without affecting the veins and not provoking an increase in heart rate. Synthesis of prostaglandin when taking the drug increases, and the degradation of bradykinin decreases.
Prolonged use of the drug helps to reduce myocardial left ventricular hypertrophy, with the development of dilatation of the left ventricle slowing down, and the progression of heart failure is completely prevented.
As a result of taking the drug myocardial blood supply improves, and platelet aggregation decreases. The hypotensive effect is observed approximately 60 minutes after taking the tablets inside. The duration of the clinical effect is up to 24 hours.

Pharmacodynamics and Pharmacokinetics

Zofenopril calcium is characterized by rapid absorption as soon as it enters the digestive tract, where absorption of the substance takes place and its absolute conversion into zofenoprilat.
The maximum level in blood plasma substance reaches 90 minutes after the first intake of tablets. Zofenoprilat binds to proteins by 88%. The substance is metabolized in the liver, forming in the process an active metabolite of zofenoprilat.
The clearance of zofenoprilat is 1300 ml / min. The substance is largely excreted through the kidneys and only 26% is excreted through the intestine.

Indications for use of Zocardis

Zocardis is indicated for treatment:
    hypertension of all degrees of severity;
    acute myocardial infarction;
    heart failure or signs of its manifestation.
Indications for use of the drug are determined by a specialist.

Contraindications

Zocardis is contraindicated in:
    the presence of a high susceptibility to the active substance or ancillary components of the drug;
    the presence of angioedema, provoked by therapy with the use of ACE inhibitors;
    violations of liver function;
    severe renal failure;
    childhood;
    with the defeat of arteries feeding both kidneys;
    hyperkalemia;
    mitral stenosis;
    aortic stenosis;
    after the operation of kidney transplantation;
    during pregnancy;
    in the period of breastfeeding take with great care.

Side effects

Reception Zocardis can provoke the development of various side effects on the part of systems and organs:
    In the work of the cardiovascular system, a decrease in blood pressure can be observed. In some cases, there is pain in the chest. The most frequent effects are arrhythmia, angina pectoris, tachycardia, syncope, pain in the heart area.
    In the work of the central nervous system, side effects appear in the form of dizziness, weakness, headache, sleep disorders, increased fatigue, anxiety.
    Side effects can also be observed from the sensory organs and expressed in the form of violations of the vestibular apparatus and noise in the ears.
    In the digestive tract, side effects are expressed in the form of dry mouth, various disorders (pain, nausea, vomiting, diarrhea, constipation, etc.). Less common are violations of liver function.
    In the activity of the respiratory system, very rarely dry cough, the development of pharyngitis, bronchospasm.
    The most common side effects are allergic reactions - rashes on the skin, myositis and extremely rare development of Stevens-Jones syndrome.

Instructions for the use of Zocardis

Take Zocardis tablets must be taken internally without binding to food intake. To maximize the rapid absorption of tablets to swallow a lot of liquid (preferably use water at room temperature).
When treating hypertension, take the pill in half (Zocardis 30) or 2 pieces (Zocardis 7.5) per day. You can take the medicine in two divided doses or once.
In the treatment of violations of water-salt balance, the taking of tablets begins with a minimum dose of ½ tablets per day. This is due to the peculiarities of therapy with ACE inhibitors, which requires the optimization of salt or water balance and the complete cessation of diuretic treatment a few days before the start of Zocardis. If necessary, the dose of the medicine can be reduced to ¼ tablets per day.
Instructions for use Zocardis advises that in the treatment of patients with impaired liver function of mild and moderate severity the initial dosage should be exactly half the usual dose of patients with normal liver function.
If the patient has a severe degree of impaired liver function, then the drug can not be used.
In the treatment of acute myocardial infarction, Zocardis is appointed in a complex therapy. Take the drug should be no later than 24 hours after the first symptoms of the disease. The duration of therapy is not less than 6 weeks.
If in the process of treatment there is a strong decrease in blood pressure, then the minimum dose is not increased, or completely abolished the drug. In patients without signs of heart failure, treatment can be discontinued after a month and a half of taking the drug.
Longer treatment with Zocardis is prescribed for patients with signs of left ventricular failure, hypertension, or general heart failure.

Overdose

If you take the drug at a dosage exceeding the recommended, the probability of developing symptoms of overdose increases:
    a sharp drop in blood pressure;
    convulsions;
    stupor.
Attention: with a sharp decrease in blood pressure, myocardial infarction, stroke, collapse or thrombolytic complications may develop.
Therefore, at the first signs of an overdose, it is necessary to contact a specialist for timely assistance.

Interaction with other drugs

Simultaneous reception of Zocardis with other medicinal preparations can provoke the appearance of undesirable reactions:
    taking the drug with antipyretic, analgesic, diuretic, antihypertensive, anesthetic agents can lead to hypotensive action;
    decrease in the hypotensive effect is possible with the simultaneous administration of the drug with NSAIDs and potassium-sparing diuretics;
    The slowdown of lithium precipitation occurs when interacting with lithium salts;
    hematotoxicity increases with the intake of alloprinol, immunosuppressants and cytostatics.

Storage conditions

Keep the drug out of reach of children at a temperature not exceeding 30 ° Celsius.
Shelf life - 3 years. The use of tablets after the expiry date is not recommended.

Terms of sale

To buy Zocardis online the prescription is not required.

Reviews about Zocardis

Due to the abundance of ACE inhibitors on the modern pharmaceutical market, reviews about Zocardis are most often found in general discussions.
And, in most cases, users draw an analogy between this drug and its analogues. For example, Anastasia B. from Perm wrote:
"The doctor prescribed this medicine for me as a means of lowering the pressure. But I'm already a shot sparrow and health problems I have a long time, so I have already taken a lot of these drugs. The most interesting thing is that I did not notice a special difference between Zocardis and Enapril. By the way, Monopril is similar to him. Pleased with only the cost - very, very pleasant. "
Direct negative feedback on the forums on the Internet is very small, which indicates the effectiveness of the drug. But I would like to draw your attention to the fact that in treatment with its use the main condition is constant contact with the attending physician, since the patient himself can feel changes in his health, but only an experienced specialist will be able to soberly evaluate the effectiveness of the prescribed therapy.