Daivonex ointment 50mcg/gr 30gr

Daivonex user manual

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Composition

Daivonex ointment in 1 milliliter contains 50 micrograms of calcipotriol. As auxiliary ingredients there are prepared water, Trilon B, liquid paraffin, sodium hydrogen phosphate dihydrate, propylene glycol, α-tocopherol, soft white paraffin and macrogol stearate.
In 1 milliliter of cream there are 52.2 micrograms of calcipotriol in the form of monohydrate. Prepared water, sodium hydroxide, white soft paraffin, sodium hydrogen phosphate hydrate, trilon B, liquid paraffin, glycerin, cetearyl alcohol, chloroallylmetamene chloride and macrogol cetostearate are also present.
In 1 milliliter of the solution, 52.2 micrograms of calcipotriol are present in the form of monohydrate. Auxiliary components: prepared water, levomentol, sodium citrate, propylene glycol, isopropanol, HPC.

Form of issue

It is available as an external agent in the form of an ointment, cream and solution. Ointment and cream are produced in aluminum tubes of 30 and 100 grams. The solution is produced in a polyethylene bottle of 60 milliliters.

pharmachologic effect

The remedy is used to treat psoriasis. The active ingredient calcipotriol is an analogue of the active metabolite of natural vitamin D₃, which inhibits the activation of T lymphocytes, which is caused by interleukin 1. The therapeutic effect is to stimulate morphological differentiation and suppress the proliferation of keratinocytes. Calcipotriol affects calcium metabolism a hundred times weaker than calcitriol.

Daivonex - hormonal or not?

Unlike Diavobet, this drug is not hormonal.

Pharmacodynamics and pharmacokinetics

The active substance is absorbed by 1-5 percent and undergoes fast-type biotransformation in the liver, after which pharmacologically inactive metabolites are formed. The half-life is very short.

Indications for use

The drug is prescribed for monotherapy psoriasis, as well as in the complex treatment of psoriasis in conjunction with Acitretinum, Corticosteroids and Ciclosporin.
The solution is applied in areas with the presence of hair.

Contraindications

Ointment and cream should not be used when:
    children under the age of 18;
    diseases that are accompanied by a violation of calcium metabolism;
    hypersensitivity to calcipotriol or other drug substance.

Caution is necessary when:

    nephrolithiasis;
    hepatic insufficiency;
    acute renal insufficiency;
    over 65 years of age.

Side effects

When using the drug can be observed:
    swelling of the face;
    depigmentation of reversible character;
    periorbital edema;
    erythema;
    hyperpigmentation of reversible character;
    skin peeling;
    itching;
    eczema;
    dry skin;
    photosensitization;
    hypercalciuria;
    exacerbation of the psoriatic process;
    angioedema;
    burning of the skin;
    different types of rash;
    skin irritation;
    contact dermatitis;
    hypercalcemia;
    dermatological allergic reactions.

Instructions for use of Daivonex (Method and Dosage)

According to the instructions for Daivonex, ointment or cream should be applied a thin layer on the affected areas one to two times a day. A day can use a maximum of 15 grams, a week - 100 grams. The therapeutic effect is observed after one or two weeks from the beginning of the application. The course of treatment is a maximum of 6-8 weeks.
For a solution, the maximum dose per week is one bottle. It is applied twice a day to the affected area.

Overdose

The use of high doses can lead to an increase in the concentration of calcium in the blood. This manifests a decrease in muscle tone, thirst, constipation, fatigue and decreased concentration of attention. In this case, it is necessary to stop using the drug.

Interaction

Diveonex can not be used concomitantly with drugs that contain salicylic acid and its derivatives.

Terms of sale

Available without a prescription.

Storage conditions

Store at a temperature of no higher than 25 degrees.

Shelf life

Shelf life of the drug is two years, after the opening of the tuba - six months.

Reviews of Daivonex

According to reviews on Daivonex in psoriasis, the drug does not help in all cases, so it is only used as directed by the doctor.
Also, according to reviews, Daivobet and Daivonex are the main drugs used to treat vulgar psoriasis.