Elidel 1% 15gr

Instruction for Elidel

You can buy Elidel cream here

Composition

1 g of cream contains 10 mg of pimecrolimus. As auxiliary components: di- and monoglycerides, stearyl alcohol, sodium hydroxide, triglycerides, cetyl alcohol, citric acid, sodium cetyl stearyl sulfate, oleyl alcohol, propylene glycol, benzyl alcohol, water.

Form of issue

Cream white, for external use, is available in aluminum tubes, in the amount of 15 and 30 g.

pharmachologic effect

Cream Elidel - hormonal or not?

This is a non-hormonal drug. The main mechanism of action is oppression of production and release of inflammatory mediators, cytokines in mast cells and T-lymphocytes. This provides anti-inflammatory effect.
Pimecrolimus inhibits calcineurin (calcium-dependent phosphatase), which leads to inhibition of proliferation of T-lymphocytes and a slowdown in the production of interleukin-2, tumor necrosis factor-α, γ-interferon, and other cytokines.
The drug reduces the secondary immune response in skin T cells, which were taken from patients suffering from atopic dermatitis.
The active substance of the drug does not affect the growth of endothelium, keratinocytes and fibroblasts. It acts selectively on immune cells, does not disrupt the function of cells of monocytic origin and Langerhans cells, does not affect the differentiation of T cells, which distinguishes pimecrolimus from corticosteroids.
The drug showed a high effect in reducing inflammation with systemic and local admission.
With allergic contact dermatitis, the cream significantly reduces inflammation reactions under the influence of skin irritants, equal in effectiveness to clobetasol-17-propionate and fluticasone, one of the most active corticosteroids. In this case, there is no skin atrophy or a change in its structure. The cream reduces the inflammatory process on the skin, itching, reduces the manifestations of histopathology, while acting on the skin selectively, - shows less penetration than glucocorticosteroids or Tacrolimus.
The main advantage of Elidel is a local (on the skin) selective anti-inflammatory effect combined with minimal systemic action on the immune response.
The course of treatment of 6 weeks for children of different ages (starting from three months) makes it possible to significantly reduce the signs of skin inflammation - redness, excoriation, infiltration, lichenization and itching. Application during the year allows to reduce the number of exacerbations, prevent the development of atrophies and increase the hypersensitivity of the skin.
The cream of Elidel is not phototoxic and does not cause photosensitization.

Pharmacodynamics and pharmacokinetics

Pimecrolimus does not have a systemic effect and its concentration in the blood is so low that it is impossible to evaluate the metabolic rate.

Indications for use

Treatment of eczema (atopic dermatitis) in adults and children from 3 months.

Contraindications

    individual intolerance;
    children up to 3 months;
    damage to the skin at the site of acute infectious infection of various origins (viral, bacterial, fungal).

It is not recommended to use:

    with systemic erythroderma and the syndrome of Netherton because of the danger of increasing the systemic absorption of the drug;
    with a decrease in immunity, since there is no experience in this category of patients;
    on areas of the skin with suspected dysplastic changes or malignant lesions.

Side effects

With the greatest frequency local reactions are observed in the form of burning, irritation, redness and itching on the skin; can be folliculitis (pustular infection).
Sometimes there are dermatitis, herpetic eczema, paresthesia, molluscum contagiosum, deterioration of the disease course.
Rarely - angioedema, hives, anaphylactic reactions; alcohol intolerance, manifested in itching, rash, face redness.
Also, in rare cases, there may be a violation of skin pigmentation.

Instructions for the use of Elidel (Method and dosage)

To obtain the best effect, treatment begins at the first signs of the disease in order to prevent progression.
The cream is applied to the skin on a thin layer and rubbed until completely absorbed. Apply ointment 2 times a day until recovery. If the symptomatology persists for more than 6 weeks, the diagnosis of atopic dermatitis needs to be clarified.
If the treatment was discontinued, but the symptoms of the disease appeared again, the application should be resumed.
Instruction for Elidel recommends the means to soften the skin after applying cream, and in case of taking water procedures - before the cream.
The maximum daily dose of the drug is not, because its systemic effect is minimal.
In case of contact with mucous membranes or eyes, rinse with water.
For children, the drug is dosed the same way as for adults.

Overdose

There were no cases of overdose.

Interaction

Given the low systemic absorption of the cream, the risk of interaction with other agents for systemic use is unlikely.
Use in children does not affect the effectiveness of vaccination. Do not apply to the area of ​​administration of the vaccine.
Ointment Elidel should not be mixed and applied simultaneously with other medicines for topical treatment.

Storage conditions

Keep out of reach of children, observe temperature not more than 25 ° C.

Shelf life

When opening the package, store up to 12 months. Shelf life of unopened cream is 2 years.

special instructions

In the course of treatment with calcineurin inhibitors, including Elidel, malignant diseases (lymphomas and skin tumors) were rarely observed. However, the relationship between drugs and these diseases has not been reliably established.
When lymphadenopathy of unknown origin or suspected of mononucleosis should be discontinued drug.
The effect of the cream on the appearance of skin lesions associated with exposure to ultraviolet radiation has not been established, but sun exposure should be avoided during treatment with Elidel.

Analogues of Elidel

The only analogue is the Protopic.
However, it can be said that the glucocorticosteroids are analogues of Elidel, since they are also used to treat atopic dermatitis. The most popular is: Advantan.

Children

Applied to children from three months. At a younger age, the effect of the drug has not been studied.

In pregnancy and lactation

Efficiency and safety have not been studied. Since the preparation has a very low degree of absorption, the probable risk is insignificant.
Nursing women should not apply the cream to the mammary glands.

Reviews about Elidel

The basic reviews about Elidel can be found on the forums of young mothers, since recently in young children diathesis has become a very common disease, and ointment is often used for babies. Reviews about the cream Elidel say that with his help quickly disappear wet crust on the cheeks, easily cleansed rash. For newborns, the drug is not used until 3 months, because they have not been monitored for efficacy and safety.
Many mothers consider the cream to be an effective substitute for ointments with hormones for dermatitis, as the use of hormones in children of many parents is alarming, and they fear that side effects may occur. The disadvantage of some was called addiction and a high price, which is more than offset by safety and effect.
The doctors' reviews show that Elidel is widely used for children. Doctors indicate as an advantage the possibility of prolonged use, which distinguishes ointment from hormonal agents. The disadvantages are the high cost of the drug and the fact that it dries out the skin. But this can be corrected by the use of softening ointments and creams. Also, according to doctors, it is necessary to remember that Elidel can not get rid of allergies, the main cause of atopic dermatitis. This is the problem of the whole organism and in the treatment you need a comprehensive approach, with the exception of allergens.