Exifine cream 1% 10gr

Exifine cream user manual

You can buy Exifine cream on this page

Composition

1 g of cream contains:
active ingredient: terbinafine hydrochloride 10 mg;
excipients: cetyl alcohol 40 mg, stearyl alcohol 40 mg, cetyl palmitate 20 mg, benzyl alcohol 10 mg, sorbitan stearate 19 mg, isopropyl myristate 80 mg, sodium hydroxide 2 mg, polysorbate 60 61 mg, purified water 718 mg.
Description:
uniform cream of white or almost white color.
Pharmacotherapeutic group:
antifungal agent

Pharmacological properties

Pharmacodynamics

Antifungal drug for local use, with a wide range of antifungal activity. At low concentrations of terbinafine has fungicidal activity against dermatophytes (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), certain molds and dimorphic fungi (Pityrosporum orbiculare). Activity against yeast is fungicidal or fungistatic, depending on the type of fungi.
Terbinafine, inhibiting squalene epoxidase in the cell membrane of the fungus, specifically inhibits the early stage of the synthesis of sterols in the cell of the fungus, which leads to a deficiency of ergosterol, intracellular accumulation of squalene and the death of the fungus cell. Squalene epoxidase is not associated with the cytochrome P450 system, therefore, terbinafine does not affect the metabolism of hormones and drugs, the metabolism of which is associated with the cytochrome P450 system.

Pharmacokinetics

Pharmacokinetics: when applied topically, absorption is less than 5%, has a slight systemic effect.

Indications for use

Prevention and treatment of fungal diseases of the skin (trichophytosis, microsporia, ruburitis) caused by susceptible pathogens, including foot mycoses - "foot fungus" and inguinal athlete's foot; yeast infections (skin candidiasis), multi-colored lichen.

Contraindications for use

Hypersensitivity to terbinafine or to the components of Exifine cream.

Carefully

Renal and / or liver failure, alcoholism, inhibition of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases of the limbs; pregnancy, lactation period, children under 12 years of age (lack of sufficient clinical experience).

Method of application and dosing regimen

Outwardly.
Before applying the drug Exifine cream must be cleaned and dried the affected areas. The cream is applied with a thin layer on the affected skin and surrounding areas and lightly rubbed. For infections accompanied by diaper rash (under the mammary glands, in the interdigital spaces, between the buttocks, in the groin area), the places of application of the cream can be covered with gauze, especially at night.
The average duration and frequency of use.
Ringworm of the trunk, legs - 1 week 1 time per day.
Inguinal athlete - 1-2 weeks 1 time per week.
Ringworm ("foot fungus") - 1 week 1 time a day.
Skin candidiasis - 1-2 weeks 1 or 2 times a day.
Multi-colored lichen - 2 weeks 1 or 2 times a day.
The duration of the treatment depends on the indication and severity of the disease. Reducing the severity of clinical manifestations observed in the first days of treatment. For the prevention of recurrence of mycoses of the feet - 2-3 courses for 2 weeks with a break of 7 days. The dosage regimen of drug Exifine cream in the elderly does not differ from the above.

Possible side effects

Itching and burning of the skin, hyperemia at the site of application.

Overdose with Exifine cream

When applied externally, it is unlikely.
Symptoms for occasional ingestion: headache, nausea, gastralgia, dizziness, frequent urination, rash.
Treatment: activated carbon, if necessary - symptomatic supportive therapy.

Interaction with other drugs

Any drug interactions for Exifine cream are unknown.

special instructions for Exifine cream

Reducing the severity of clinical manifestations is usually observed in the first days of treatment. Irregular use or early termination of treatment increases the risk of recurrence.
If after 2 weeks. treatment is not marked improvement, it is necessary to re-identify the causative agent and its sensitivity to Exifine cream.
In the course of treatment, it is necessary to follow general rules of hygiene to prevent re-infection (through underwear, shoes).
Avoid getting the cream in the eyes and on the mucous membrane of the nasal cavity, mouth. Exifine cream has a slight systemic effect, therefore, it is unlikely to affect driving and other potentially hazardous activities that require high concentration of attention and psychomotor reactions.

Release form

Cream for external use 1%.
On 10 g in a tube from the varnished aluminum.
Each tube with instructions for use is placed in a cardboard box.

Storage conditions

At a temperature not higher than 25 ° С. Do not freeze.
Shelf life - 3 years.
Do not use after the expiration date printed on the package.

Pharmacy sales terms

To buy Exifine cream the prescription is not required.