Exifine gel 1% 15gr

Exifine instruction for use

You can buy Exifine here

The composition and release form of the drug

Gel for external use from white to almost white color, homogeneous, without visible foreign particles.
1 g
terbinafine 10 mg
Excipients: isopropyl myristate, butylhydroxytoluene, benzyl alcohol, sorbitan laurate, polysorbate 20, carbomer 974P, sodium hydroxide, disodium edetate, ethanol, purified water.
15 g - aluminum tubes (1) - cardboard packs.
30 g - aluminum tubes (1) - cardboard packs.

pharmachologic effect of Exifine

Antifungal agent of the allylamines group. It has an effect due to the suppression of squalene epoxidase in the cell membrane of the fungus. This leads to a deficiency of ergosterol and to the intracellular accumulation of squalene, which causes the death of the pathogen cell.
It has a fungicidal effect on dermatophytes, mold and some dimorphic fungi, yeast and yeast-like fungi. Some types of yeast fungus can act fungistatically.
Active against pathogens of ringworm (Trichophyton / including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum /, also Microsporum canis and Epidermophyton floccosum); yeast-like fungi of the genus Candida (mainly Candida albicans); pathogen multicolor lichen (Malassezia furfur).

Pharmacokinetics

After ingestion is well absorbed from the gastrointestinal tract. Plasma protein binding - 99%. Terbinafine diffuses through the dermal layer of the skin and accumulates in the lipophilic stratum corneum, secreted into sebum, resulting in high concentrations in hair follicles and nails. During the first few weeks after the start of treatment, terbinafine accumulates in the skin and nail plates in concentrations that provide fungicidal action. Metabolized in the liver to form inactive metabolites. Excreted in the urine, mainly in the form of metabolites. T1 / 2 - 17 h.

Indications for Exifine

For oral administration: fungal skin lesions caused by dermatophytes - trichophytia, athlete, microsporia, fungal nail infections (onychomycosis), candidiasis.
Exifine for external use: fungal skin lesions caused by dermatophytes, candidiasis; multi-colored versicolor.

Contraindications

Hypersensitivity to terbinafine.

Dosage

Inside adults - 250 mg / day in 1 or 2 doses. The duration of treatment depends on the indications and severity of the infection: for skin lesions - 2-4 weeks, for nails - from 6 weeks. up to 4 months or more. Children weighing more than 40 kg - 250 mg / day, 20-40 kg - 125 mg / day, up to 20 kg - 62.5 mg / day.
Externally used 1-2 times / day for 1-2 weeks.

Side effects of Exifine

On the part of the digestive system: nausea, anorexia, mild abdominal pain, diarrhea, disturbances or loss of taste, cholestasis, jaundice, hepatitis.
Allergic reactions: skin rash; rarely - arthralgia, myalgia, erythema multiforme, Stevens-Johnson syndrome.
CNS: headache.
From the side of the hemopoietic system: neutropenia, thrombocytopenia.
Local reactions: hyperemia, itching, burning sensation.

Drug interaction

Drugs that induce microsomal liver enzymes increase the clearance of terbinafine; drugs that inhibit microsomal liver enzymes - reduce the clearance of Exifine.

special instructions

Exifine should be used with caution for oral administration in patients with impaired liver and / or kidney function, as well as in elderly people.

Pregnancy and lactation

Experience with Exifine during pregnancy is limited. If necessary, appointments during lactation should decide on the termination of breastfeeding.

Use in childhood

The use is possible according to the dosing regimen.

In case of impaired renal function

It is necessary to use caution terbinafine for oral administration in patients with impaired renal function.

With abnormal liver function

It is necessary to use caution terbinafine for oral administration in patients with impaired liver function.

Use in old age

It is necessary to use caution terbinafine in the elderly.

Terms of sell

You can buy Exifine without a prescription.