Lamisil cream 1% 15gr

Lamisil instruction manual

You can buy Lamisil here

Composition

The Lamisil tablets contain the active ingredient terbinafine (in the form of hydrochloride), as well as additional components: colloidal anhydrous silicon dioxide, magnesium stearate, sodium starch glycolate, MCC, methylhydroxypropylcellulose.
Lamisil spray contains hydrochloride as an active ingredient in terbinafine, as well as additional components: 96% ethanol, macrogol cetostearate, propylene glycol, water.
The composition of the Cream includes the active ingredient terbinafine hydrochloride, as well as additional substances: sodium hydroxide, benzyl alcohol, sorbitan stearate, stearyl alcohol, cetyl palmitate, cetyl alcohol, isopropyl myristate, polysorbate 60, water.

Form of issue

Several forms of this drug are produced.
Lamisil tablets can be white or white and yellow, they are biconvex, round, with a risk, with a facet. On a circle of a tablet - an inscription «LAMISIL 250». The surface of the tablet is roughened. Contained in blisters for 7 or 14 pieces, blisters are embedded in cardboard bundles.
Spray Lamisil is a colorless transparent liquid (can have a light yellow hue), which has a characteristic smell. Contained in bottles of polyethylene, equipped with a spray-tip, 15 and 30 ml. The bottle is put in cardboard packs.

Cream Lamisil - homogeneous, white, has a weak characteristic odor. Contained in aluminum tubes of aluminum for 15 and 30 g. The tubes are put in cardboard packs.
pharmachologic effect

Lamisil is an antifungal agent.

Terbinafine is allylamine, which has a wide range of effects on fungi. It acts on mushrooms, which cause diseases of hair, nails, skin. These are Trichophyton fungi (for example, Trichophyton tonsurans, Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton violaceum, Trichophyton verrucosum), Epidermophyton floccosum, Microsporum (Microsporum canis), yeast fungi Candida (Candida albicans) and Pityrosporum.
When low concentrations are used, terbinafine produces a fungicidal effect against dermatophytes, molds and a number of dimorphic fungi. Concerning yeast fungi demonstrates fungicidal or fungistatic activity.
Under the influence of terbinafine, the biosynthesis of sterols in the cell is specifically suppressed at the earliest stage. As a result, there is a lack of ergosterol and accumulation of squalene inside the cells, as a result of which the cells of the fungus die. The effect of terbinafine is by inhibiting the enzyme squalene epoxidase in the membrane of fungal cells.
If Lamisil is administered orally, then skin concentrations, nails and hair accumulate those drug concentrations that provide a fungicidal effect.
With external application the preparation also demonstrates a wide range of antifungal activity.
Terbinafine does not affect the cytochrome P450 system, so it has no effect on the metabolism of hormones and other drugs.

Pharmacokinetics and pharmacodynamics

After Lamisil in tablets was ingested, terbinafine is absorbed well, the level of absolute bioavailability of terbinafine due to the effect of "first passage" is about 50%. After the drug was taken at a dose of 250 mg orally, the maximum level of plasma concentration is noted after 1.5 hours.
The maximum concentration increases if the drug is taken regularly.
On the bioavailability of the active substance, food intake is slightly affected, therefore, it is not necessary to adjust the dose of the drug when taken concomitantly with food.
With plasma proteins terbinafine binds to 99%. Its rapid penetration through the dermal layer of the skin, concentration in the lipophilic stratum corneum is noted. Also noted are its high concentrations in hair, hair follicles, in the skin with a lot of sebaceous glands. In the nail plates, the presence of the active component of the drug in the first weeks after the start of treatment is determined.
Rapidly metabolized, due to the biotransformation of terbinafine, metabolites are formed that do not show antifungal activity, are mainly excreted through the kidneys.
If the Lamisil cream or spray is applied externally, the absorption of terbinafine is less than 5%. There is a slight systemic effect.

Indications for use

Taking Lamisil tablets is advisable in the following cases:
    with onychomycosis, which occurs due to the action of fungi of dermatophytes;
    with mycosis of the scalp;
    with fungal infections of the skin - treatment of foot fungus, dermatomycosis of shins, trunk, as well as for the treatment of infections provoked by fungi of the genus Candida.
It should be taken into account that Lamisil for oral administration is not an effective remedy for multicolored lichen.
Use cream and spray Lamisil is advisable in the following cases:
    with the goal of preventing foot mycoses, fungal lesions of smooth skin, inguinal epidermophytes, which were provoked by dermatophytes;
    For the treatment of diaper rash provoked by molds;
    for the treatment of varicolored lichen, provoked by dimorphic fungi.

Contraindications

The remedy is not prescribed to people who suffer from hypersensitivity to the components of the medicine. Do not use Lamisil for treatment of nail fungus and other diseases if the patient suffers from liver disease, both chronic and acute. Therefore, before starting treatment, it is necessary to determine whether the patient does not suffer from such diseases.
It should also be noted that there may be a hepatotoxicity in people with liver disease, as well as in those who did not suffer from such diseases. Therefore, patients should be aware that if you experience persistent nausea, fatigue, jaundice, pain in the right hypochondrium, darkening of urine, etc., you should always consult a specialist and conduct a liver examination.
It is not recommended to take Lamisil to people with impaired renal function.

Side effects

Patients generally tolerate Lamisil well, side effects tend to be mild or moderate and transient. Negative manifestations can be as follows:
    Hemopoiesis: in very rare cases - agranulocytosis, neutropenia, pancytopenia, thrombocytopenia.
    The immune system: in very rare cases - lupus erythematosus, anaphylactoid reactions.
    Nervous system: headache, taste disorders until loss, in rare cases - paresthesia, dizziness, hypoesthesia.
    Hepatobiliary system: in rare cases - hepatobiliary dysfunction, hepatic insufficiency.
    Digestion: deterioration of appetite, sensation of stomach overflow, nausea, indigestion, diarrhea, abdominal pain.
    Skin reactions: mild skin manifestations in the form of hives and rashes, in rare cases - severe skin reactions, exacerbation of psoriasis, hair loss.
    Musculoskeletal system: myalgia, arthralgia.
    When applying the spray, allergic skin manifestations can develop.

Instructions for use Lamisil (Method and dosage)

The duration of application of all forms of the drug depends on the severity of the disease and the appointment of a doctor.

Lamisil cream, instructions for use

Cream can be applied 1-2 times a day for the treatment of adult patients and children after 12 years. Before applying the product, it is necessary to thoroughly clean the skin and dry it. The cream should be applied to the affected areas of skin, as well as to places near them. Apply a thin layer and rubbed lightly into the skin. If it is necessary to cure intertrigo, you can cover the places on which the cream is applied with gauze. It is advisable to do this at night. With dermatomycosis, the stop treatment lasts for 1 week, the cream should be applied once a day. If the remedy is prescribed for cracks, itching of the skin that develops as a result of the fungus, the treatment lasts two weeks, the drug should be applied 1-2 times a day. Patients with candidiasis of the skin should use the cream 1-2 times a day, the treatment, depending on the patient's condition, lasts 1-2 weeks. Patients with multi-colored lichen should be treated for two weeks, applying Cream 1-2 times a day. If the remedy for the foot fungus and other diseases is not used regularly, the risk of recurrence of the infection increases.
Acceleration of the plasma clearance of terbinafine is observed under the influence of drugs - inducers of metabolism, inhibition - under the action of inhibitors of cytochrome P450. If you want to apply these drugs at the same time, you should adjust the dosage of Lamisil.
The effect of cimetidine increases the effect of terbinafine, and can also increase its concentration in the plasma. The terbinafine clearance is reduced by 33% under the influence of cimetidine.
Rifampicin lowers the effect of terbinafine or reduces the concentration of this substance in the plasma. Under the influence of Rifampicin, terbinafine clearance is increased by 100%.
There is evidence that terbinafine may increase the concentration of caffeine in the plasma or enhance its effect. The clearance of caffeine when administered intravenously by terbinafine is reduced by 19%
The clearance of desipramine while concomitantly taking terbinafine is reduced by 82%.
Terbinafine weakens the effect of Ciclosporin and reduces its concentration in the plasma. Cyclosporine clearance is increased by 15% under the influence of terbinafine.

Storage conditions

It is necessary to protect all forms of the drug from exposure to light, the storage temperature should not exceed 30 ° C. It is impossible to freeze the remedy.

Shelf life

Tablets and cream Lamisil can be stored for 5 years, spray - 3 years,

special instructions

There is no evidence of the effect of this drug on the ability to drive vehicles or work with precise mechanisms. If dizziness is noted against the background of treatment, you should refrain from these actions.
If the patient has a large fungal lesion, he should use a spray in a large vial - 30 ml.
As a rule, clinical manifestations decrease in the first few days of treatment. If the therapy is intermittent or interrupted, the infection may resume.
In the event that no improvement occurs one week after the start of treatment, you should consult your doctor and clarify the diagnosis.
Care should be taken to apply the spray to the skin if there is damage, as alcohol can provoke irritation. It must be ensured that the spray does not hit the eyes. If this happens, you should immediately wash your eyes with water. If skin irritation occurs, consult a doctor.
If allergic reactions develop, stop taking the drug.
Lamisil for nails is also available in the form of a varnish, but it is exclusively for the specialist to prescribe such a varnish.

Children

Tablets are given to children after 2 years. Cream and spray should not be used to treat children under 12 years old.

In pregnancy and lactation

Lamisil during pregnancy in the absence of a sufficient number of research results is not applied. The use of the drug is possible only if the expected benefit exceeds the possible risk. Lactation during treatment should be suspended.

Reviews about Lamisil

Users write that Lamisil is a drug that effectively cures nail fungus. Reviews about Lamisil in tablets are more often positive: patients note that their use allowed a few days to reach a visible result. Those who write reviews about Lamisil cream and reviews about Lamisil spray often tell that the quickest result can be obtained by combining the use of tablets and external forms of Lamisil. We melted, even those who used Cream or nail polish, often ascertained that the nail fungus and other diseases associated with fungal infection could be cured. But sometimes in the network there are also negative reviews of those who consider the medicine ineffective.