Lamisil spray 1% 30ml

User manual for Lamisil spray

You can buy Lamisil spray online

Release form, composition and packaging

Spray for external use in the form of a clear, colorless or light yellow liquid with a characteristic odor.
1 g
terbinafine hydrochloride 10 mg
Excipients: water - 670 mg, ethanol 96% - 250 mg, propylene glycol - 50 mg, macrogol cetostearate - 20 mg.

pharmachologic effect

Antifungal drug for external use, with a wide range of antifungal activity. At low concentrations of terbinafine has fungicidal activity against dermatophytes (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), some mold and dimorphic fungi (Pityrosporum orbiculare). Activity against yeast fungi, depending on their species, can be fungicidal or fungistatic.
Terbinafine in a specific way changes the early stage of sterol biosynthesis occurring in fungi. This leads to a deficiency of ergosterol and to the intracellular accumulation of squalene, which causes the death of the fungal cell. The action of terbinafine is carried out by inhibiting the enzyme squalene epoxidase, located on the cell membrane of the fungus.
Terbinafine does not affect the cytochrome P450 system in humans and, accordingly, the metabolism of hormones or other drugs.

Pharmacokinetics

When applied topically, absorption of less than 5% has a slight systemic effect.

Indications for Lamisil spray

Prevention and treatment of fungal infections of the skin:
- mycoses of the feet (tinea pedis); horniness, cracks, itching and peeling of the skin caused by foot fungus; athlete's groin (tinea craris), fungal lesions of the smooth skin of the body (tinea corporis) caused by dermatophytes such as Trichophyton (including T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum;
- yeast infections of the skin, mainly those caused by fungi of the genus Candida (for example, Candida albicans), in particular diaper rash;
- versicolor versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare (Malassezia furfur).

Contraindications

- hypersensitivity to terbinafine or to any of the inactive ingredients that make up the drug;
- the period of breastfeeding;
- children's age up to 12 years (Lamisil cream);
- children's age up to 18 years (Lamisil spray).
With caution, the drug is prescribed to patients with hepatic and / or renal failure, patients with chronic alcoholism, with inhibition of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases of the extremities.

Dosage of Lamisil Spray

In adults, Lamisil spray can be applied 1 or 2 times / day, depending on the evidence. Before using the drug, it is necessary to thoroughly clean and dry the affected areas. The drug is sprayed on the affected areas in an amount sufficient to thoroughly moisturize them, and, in addition, applied to adjacent areas of both affected and intact skin.
In case of extensive fungal infections of the body, it is recommended to apply a spray in vials of 30 ml each.
Frequency of use of the drug and the duration of treatment: ringworm of the body, legs - 1 time per day for 1 week; dermatomycosis stop - 1 time / day for 1 week; multi-colored lichen - 2 times / day for 1 week; groin athlete, diaper rash - 1 time per day for 1 week.

Side effects

Determination of frequency of side effects (WHO): very often (≥1 / 10), often (≥1 / 100 and <1/10), infrequently (≥1 / 1000 and <1/100), rarely (≥1 / 10 000 and <1/1000), very rarely (<1/10 000), including individual messages.
On the part of the immune system: individual messages - hypersensitivity reactions (rash).
From the side of the organ of vision: rarely - irritation of the eyes.
From the skin: often - skin peeling, itching; infrequently - skin damage, crust formation, skin lesions, pigmentation disorders, erythema, burning sensation of the skin; rarely - a feeling of dry skin, contact dermatitis, eczema; individual messages - a rash.
Local reactions: infrequently - pain, pain at the site of application, irritation at the site of application; rarely, exacerbation of symptoms. In places where the drug is applied, itching, skin flaking, pain, irritation, skin pigmentation change, burning, erythema, and cortex can be observed. These minor symptoms should be distinguished from hypersensitivity reactions such as rashes that occur in rare cases and require the withdrawal of therapy. In rare cases, the course of a fungal infection may worsen.
If any of these side effects worsen, or the patient has noticed any other side effects, you should inform your doctor.

Overdose

No cases of Lamisil overdose have been reported.
Symptoms: random intake of 30 ml of Lamisil spray containing 300 mg of terbinafine hydrochloride is comparable to taking 1 tablet of Lamisil with a dosage of 250 mg (single dose for an adult). If you take a larger amount of Lamisil spray by mouth, you can expect the development of the same side effects as with an overdose of Lamisil tablets (headache, nausea, epigastric pain and dizziness). It should also be noted that the spray contains ethyl alcohol (28.87% (v / v)).
Treatment: activated charcoal, if necessary, perform symptomatic therapy.

Drug interaction

Currently, the drug interaction drug Lamisil is unknown.

special instructions for Lamisil spray

Reducing the severity of clinical manifestations is usually observed in the first days of treatment. In the case of irregular use or its premature termination there is a risk of recurrence of the infection.
The drug is intended for external use only.
Avoid getting the drug in the eye, because It may cause irritation. In case of accidental contact, the eye should be rinsed immediately with running water, and in case of persistent irritation, consult a physician.
When developing allergic reactions, it is necessary to cancel the drug.
Cream Lamisil for external use contains cetyl and stearyl alcohols, which can cause local allergic reactions (contact dermatitis) in the places of application.
Care should be taken when applying Lamisil spray on damaged skin, as ethanol, which is part of it, can cause irritation. Lamisil Spray is for external use only. Do not use Lamisil spray on the skin of the face. If the Lamisil spray was accidentally injected into the respiratory tract by inhalation, then if there are any symptoms and especially when they persist, consult a doctor. Spray Lamisil contains propylene glycol, which in some cases can cause skin irritation. It should also be borne in mind that the drug contains ethanol 96%.

Pregnancy and lactation

Since the clinical experience of using Lamisil cream in pregnant women is very limited, it should not be used, except in cases of extreme necessity. In pregnancy, the drug is used only if the intended benefit to the mother outweighs the potential risk to the fetus. Need to consult a doctor.
In experimental studies teratogenic properties of terbinafine were not revealed. To date, no developmental disabilities have been reported with Lamisil.
Terbinafine is excreted in breast milk, so the drug should not be prescribed to nursing mothers. The infant should not be allowed to contact any surface of the skin treated with Lamisil.

Application in childhood

Lamisil Cream is contraindicated in children under the age of 12 years.
Lamisil Spray is contraindicated in children under 18 years of age.

In case of impaired renal function

With caution appoint the drug to patients with kidney failure.

With abnormal liver function

With caution appoint the drug to patients with hepatic insufficiency.

Application in old age

Correction of the dosage of Lamisil cream in elderly patients is not required.

Pharmacy sales terms

You don't need a prescription to buy Lamisil spray.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not higher than 30 ° C. Shelf life - 5 years.