Lamisil Uno solution 1% 4ml

Lamisil Uno user manual

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Composition

Lamisil Uno in the composition contains the active ingredient terbinafine hydrochloride, also in the composition there are additional components: acrylic acid and octylacrylamide copolymer, medium chain triglycerides, giprolose, 96% ethanol.

Form of issue

Lamisil Uno is produced in the form of a film-forming solution for external application, 1%. The solution is viscous, it can be transparent or slightly opaque, colorless or yellowish. Has a smell of ethanol.

pharmachologic effect

The use of terbinafine in small concentrations provides a fungicidal effect against dermatophytes, mold fungi and some dimorphic fungi. Demonstrates the activity and relative to yeast fungi, depending on their type, the action can be fungicidal or fungistatic.
Under the influence of terbinafine, the early stage of the process of sterol biosynthesis, which occurs in fungi, specifically changes. As a consequence, there is a lack of ergosterol and the accumulation of squalene inside the cells. As a result, the fungus cells die. Terbinafine acts by inhibiting the enzyme squalene epoxidase, which is located on the cell membrane of the fungus. This enzyme has no relation to the cytochrome P450 system. On the process of metabolism of hormones or other drugs, the active substance of the drug Lamisil Uno does not affect.

Pharmacokinetics and pharmacodynamics

After the solution is applied to the skin, a transparent film forms, which remains on the skin for 72 hours. Terbinafine, which is in the film, is rapidly absorbed into the stratum corneum of the dermis. Approximately 16-18% of the dose applied to the skin after 60 minutes is determined in the stratum corneum. The process of release of the active substance is progressive.
Insufficient systemic bioavailability, when applied topically - less than 5%. After three months of using the drug, there is a low level of relapses - no more than 12.5%.

Indications for use

The agent is indicated for use in foot mycoses.

Contraindications

Do not use Lamisil Uno to treat those patients who have a high sensitivity to both terbinafine and other components of this medication.
Carefully prescribe the drug to people suffering from kidney failure, liver failure, alcoholism. Also, with caution appoint Lamisil Uno to people with tumors, metabolic diseases, oppression of bone marrow hematopoiesis, occlusive diseases of the vessels of the extremities.
In the absence of emergency, the drug is not prescribed to pregnant women, nursing mothers and children under 15 years of age.

Side effects

Negative manifestations with the use of this drug develop only in rare cases, if they are weakly expressed and manifest for a short time.
The following manifestations are possible:
    systemic reactions: redness, rash, hives, dermatitis;
    local manifestations: a burning sensation in the place where the preparation was applied, as well as dryness and irritation of the skin.

Instruction for Lamisil Uno (Method and Dosage)

The drug should be used only externally. Ointment can be applied to adult patients and adolescents after 15 years. Instructions for the use of the ointment provides that, for the purpose of treating the foot fungus, the drug is applied one-time to both feet, and it does not matter if only one foot is affected by the infection. This must be done to ensure that even those fungi that are on the foot are destroyed, but the lesions are not visually visible.
Before applying the medicine, you need to wash and thoroughly dry your feet and hands. The feet are treated with the solution in turn. You need to start from the areas between the fingers, then gradually apply the solution on the entire surface - on the sole and on the sides by about 1.5 cm. As a rule, one half of the tube of the remedy is needed to process one foot. For 1-2 minutes you need to wait for the solution to dry and form a film. After finishing the treatment, wash hands. The agent does not need to be rubbed into the skin. Repeatedly on the skin, treated with a solution, Lamisil Uno should not be applied.

Overdose

There are no data on cases of overdose by the agent.
If the patient accidentally uses the medicine inside, he may have a headache, dizziness, nausea, pain in the epigastrium. In such a case, it is necessary to take activated charcoal, if necessary, to apply symptomatic treatment.

Interaction

There is no data on the interaction of Lamisil Uno with other drugs.

Terms of sale

It is sold without a prescription.

Storage conditions

Keep Lamisil Uno in its original packaging, store at a temperature of no more than 30 ° C., Keep out of the reach of children.
Shelf life - 3 years.

special instructions

Do not use Lamisil Uno in chronic plantar hyperkeratosis triggered by Tinea pedis.
Do not apply the product to the skin of the face, as it can provoke irritation of the mucous eyes. If the solution gets into your eyes accidentally, they should be rinsed immediately with water.
If the patient exhibits an allergic reaction after applying the solution, the film must be removed immediately using an organic solvent (denatured alcohol is suitable). After this, wash feet with soap and water. For allergies, the drug should not be used.
For the effect to be more pronounced, after the treatment of the feet they are not washed for 24 hours. Therefore, Lamisil Uno should be applied after hygienic procedures.
If after applying the drug there is little remedy in the tube, it must be immediately destroyed.
In the absence of improvement in a few days, you should see a doctor.
The use of the drug has no effect on the severity of the reaction.

Children

There is insufficient data on the use of Lamisil Uno for the treatment of children. In the annotation to the drug is not recommended to use it for the treatment of children under 15 years.

In pregnancy and lactation

Since there is no sufficient clinical experience in the use of a solution for the treatment of pregnant women, the drug can be used only if there is strict evidence and under the supervision of a doctor. As terbinafine enters the breast milk, breastfeeding should be suspended for the period of treatment.

Reviews of Lamisil Uno

Reviews of Lamisil Uno on the forums indicate that this remedy effectively cures foot fungus. Users write that it is convenient to apply the solution, and improvement is noted after a few days. Negative reviews about Lamisil Uno ointments are associated mainly with the high cost of the drug.