Fungoterbine spray 1% 30ml

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Composition

Spray (1 gram) contains: 10 mg terbinafine hydrochloride, urea, ethyl alcohol, propylene glycol, dibunol, povidone.

Form of issue

    The drug is released in the form of white flat tablets, round, with a risk in the middle. In a carton 1 cell pack, 10 tablets.
    Cream Fungoterbine has a uniform consistency and a slight specific odor. Color - white or almost white, opaque. Ointment is sold in tubes of 15 grams.
    Spray is a clear, colorless liquid, odorless and tasteless. Produced in vials of 15 or 30 ml.

pharmachologic effect

Antifungal, fungicidal.

Pharmacodynamics and pharmacokinetics

The active substance is a broad antifungal spectrum of action. Terbinafine stops the synthesis of ergosterol (inhibits the enzyme squalene epoxidase), thereby disrupting the biosynthetic processes in the fungal cells. The drug is active against dimorphic fungi, dermatophytes and various molds.
The medicine has no effect on the hormonal background, or the metabolism of other drugs. The urea included in the composition promotes better penetration of the agent into the cells, accelerates the processes of tissue repair on the areas affected by the fungus.
After taking the tablets within 2 hours, max. concentration in blood plasma. About 90% of the substance binds to proteins in the plasma.
The substance has the property to accumulate in the sebaceous glands, hair follicles, hair, after 7-14 days of regular use - in the nail plates and horny layer of the skin.
The half-life period is 16-19 hours, the drug is excreted through the kidneys (its inactive metabolites) and with a horny layer of skin. For people with liver or kidney disease, the lengthening of the excretion period is possible.
When using the cream and spray, approximately 5% of the active substance enters the blood plasma, which in no way reflects on the processes occurring in the body.

Indications for use

Spray Fungoterbine, as a rule, is used to treat seborrhea that has arisen on the hair-covered part of the head.

Contraindications

The agent is not prescribed:
    children under 12 years;
    when allergic to its components;
    pregnant and lactating women.
The tablet form can not be used for persons with kidney and liver diseases, with lactase deficiency.

Care should be taken:

    with tumors of various kinds;
    with red lupus erythematosus;
    alcoholics;
    at problems with a hemopoiesis;
    with pathological processes in the vessels;
    at metabolic disorders.

Side effects

When using the cream and spray, hypersensitivity reactions on the skin, itching, burning sensation, rashes, up to urticaria and Quincke's edema may appear. Different types of adverse reactions should be distinguished.
Also when taking tablets were observed:
    arthralgia or agranulocytosis;
    pain in the epigastric region;
    indigestion;
    lymphopenia;
    anorexia;
    distortion of taste;
    thrombocytopenia;
    neutropenia;
    myalgia;
    Stephen-Johnson syndrome.

Instructions for use (Method and dosage)

Depending on the disease and its severity, a different dosage and dosage form of the drug is recommended.

Instruction for spray

It is applied externally. The agent is also applied to pre-cleaned and dried areas. After application, the skin should become evenly moist. In addition to the affected areas, it is recommended that the surrounding skin be treated.
Multiplicity of reception is the same as for the cream.

Overdose

With an overdose of tablets, side effects may increase and dyspepsia may occur. Therapy depends on the manifestations of adverse reactions.
If the cream gets inside, you should rinse the stomach and perform symptomatic therapy.

Interaction

Tablets should be combined with caution with rifampicin, antagonists of histamine H2 receptors, terfenadine, oral contraceptives, caffeine, hepatotoxic agents, microsomal oxidation inducers and drugs in the metabolism of which the cytochrome P450 system participates.

Storage conditions

At a temperature not exceeding 20 degrees.
Shelf life - 2 years.

special instructions

Improvements in the condition should appear no later than 2 weeks after the start of treatment. Typically, this occurs during the first days of use. If this did not happen, you need to clarify the diagnosis.
Dosage adjustment for elderly patients is not required.
Avoid contact with the cream and spray in the eyes and mucous membranes, in the digestive tract.

In pregnancy and lactation

Taking the drug during pregnancy is possible after consultation with a specialist. During the studies, teratogenic properties of the drug were not revealed. When taking pills, breastfeeding should be discontinued, as the drug is excreted in breast milk.

Reviews of Fungoterbine

Reviews about Fungoterbine are good. The cream quickly and effectively relieves the fungus, especially on the feet. Has a convenient form of release, relatively inexpensive. Some patients are prescribed pills. When they are taken, adverse reactions appear rarely, the medication is quite effective compared to analogues. In addition to reviews on Fungoterbin ointment, many write about the experience of using a spray to treat fungal diseases on the head. The drug works well in the early days of the disease.