Fucidin ointment 2% 15gr

Fucidin ointment instruction

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The composition and release form of the drug

Ointment for external use 2% homogeneous, translucent, from yellowish to white.
1 g
sodium fuzidat 20 mg
Excipients: lanolin - 46 mg, cetyl alcohol - 4 mg, liquid paraffin - 140 mg, white soft paraffin - 790 mg.
15 g - aluminum tubes (1) - cardboard packs.

pharmachologic effect

Antibiotic. It has a bacteriostatic or bactericidal effect. The mechanism of action is associated with the suppression of protein synthesis due to inhibition of the factor required for the translocation of protein subunits and the elongation of the peptide chain, which further leads to the death of the pathogen.
Highly active against Staphylococcus spp., Especially Staphylococcus aureus and Staphylococcus epidermidis (including methicillin-resistant strains), Nocardia asteroides, Clostridium spp.
Less active against Streptococcus spp., Enterococcus spp., Neisseria spp., Bacteroides spp., Mycobacterium tuberculosis, Mycobacterium leprae.
Fusidic acid is active against some protozoa, including Giardia lamblia, Plasmodium falciparum.

Pharmacokinetics

After ingestion and in / in the introduction of widely distributed in the body. Fusidic acid accumulates in pus, sputum, bone tissue, synovial fluid, sequesters, burn scabs, abscesses of the brain in concentrations exceeding the IPC for Staphylococcus aureus (0.03-0.16 mg / ml). Metabolized in the liver. It is removed with bile, a small amount - with urine.
When Fucidin ointment applied externally, fusidic acid penetrates well through both damaged and healthy skin, while systemic absorption is low.
When applied topically it penetrates intraocular fluid. Therapeutic concentrations are stored in the lacrimal and intraocular fluid for at least 12 hours.

Indications

Infectious and inflammatory diseases caused mainly by Staphylococcus spp .: for oral and intravenous administration - brain abscess, infections of bones and joints, endocarditis, eye, septicemia, pneumonia, infections of the skin and soft tissues, infectious and inflammatory complications of cystic fibrosis wound infection; for external use - impetigo, carbuncles, furuncles, infected wounds, hydradenitis, folliculitis, paronychia, sycosis of beard, erythrasma, acne vulgaris; for local use in ophthalmology - conjunctivitis, blepharitis, barley, dacryocystitis, keratitis, infections associated with the removal of a foreign body from the conjunctiva and the cornea.

Contraindications

Hypersensitivity to fusidic acid.

Dosage of Fucidin ointment

Adults inside - 500 mg every 8 hours. Children under the age of 1 g - 50 mg / kg / day in 3 doses, at the age of 1-5 years - 250 mg 3 times / day, at the age of 5-12 years - by 500 mg 3 times / day, over 12 years old - 750 mg 3 times / day.
For adults and children over 12 years old, by mouth - 250-500 mg 2-3 times / day. Adults in / in the form of infusions - 500 mg 3 times / day. Duration of infusion - not less than 2 hours.
For children under the age of 12, by mouth - 50 mg / kg / day in 3 divided doses; in / in - 20 mg / kg / day, the frequency of administration - 3 times / day.
The maximum daily dose of Fucidin ointment for adults with a / in the introduction is 2 g.
When applied topically, fusidic acid is applied with a thin layer to the affected skin 2-3 times / day for 7 days. When treating acne vulgaris, longer courses of therapy are required.
Locally for eye diseases used 2 times / day. Treatment should be continued for 2 days after the disappearance of the clinical symptoms of the disease.

Side effects of Fucidin ointment

On the part of the digestive system: possible dyspeptic symptoms, jaundice, abnormal liver function.
Allergic reactions: possible skin rash.

Drug interaction

With simultaneous use of colestyramine, the formation of insoluble complexes occurs, which leads to a decrease in the concentration of fusidic acid in the blood plasma.
With the simultaneous use of fusidic acid with penicillins resistant to the action of penicillinases, cephalosporins, erythromycin, rifampicin, lincomycin, additive effect or synergism is observed.

Pharmaceutical Interaction

Solutions for infusions containing fusidic acid are incompatible with kanamycin, gentamicin, vancomycin, cefaloridin, carbeneucillin, amino acid solutions, blood substitutes and calcium-containing drugs. The precipitation of fusidic acid can occur in infusion solutions at pH below 7.4.

special instructions for Fucidin ointment

It should be borne in mind that fusidic acid can be used in cases of impaired renal function and in cases when the use of other antibiotics is contraindicated.
No marked cross-sensitivity to other antibiotics.
In severe infections, as well as in cases where long-term treatment is necessary, Fusidic acid should be combined with other antibiotics active against staphylococci in order to reduce the risk of developing resistance.

Pregnancy and lactation

If necessary, use during pregnancy and lactation should assess the intended benefits to the mother and the potential risk to the fetus.
In experimental studies found that fusidic acid does not have a teratogenic effect.
Fusidic acid gets through a placental barrier. In in vitro experiments, it was found that fusidic acid replaces bilirubin in connection with albumin. Therefore, the use of fusidic acid in the third trimester of pregnancy due to the possible development of nuclear jaundice in newborns should be avoided. This fact should be taken into account when it is necessary to use it in newborns (including premature babies) of children with jaundice and acidosis.
Fusidic acid is excreted in breast milk in very low concentrations.

Use in childhood

The use is possible according to the dosing regimen.

In case of impaired renal function

It should be borne in mind that fusidic acid can be used in cases of impaired renal function and in cases when the use of other antibiotics is contraindicated.

Terms of sell

You don't need a prescription to buy Fucidin ointment.